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A New Handheld Device for the Detection of Falsified Medicines: Demonstration on Falsified Artemisinin-Based Therapies from the Field.
Am J Trop Med Hyg. 2017 May; 96(5):1117-1123.AJ

Abstract

AbstractPoor-quality medicines are a major problem for health-care systems in resource-poor settings as identifying falsified medicines requires a complex laboratory infrastructure such as a Medicines Quality Control Laboratory. We report here an evaluation of a low-cost, handheld near-infrared spectrometer (NIRS) device by analyzing a library of artemisinin-based combination therapy (ACT) medicines to determine its usefulness as a drug-screening tool. The "SCiO" research prototype device was used to collect NIR spectra of a library of ACT and artesunate monotherapy medicine samples previously collected in Bioko Island and Equatorial Guinea and Kintampo, Ghana. The quality of these samples had been categorized as falsified, substandard, and quality assured based on the amount of stated active pharmaceutical ingredients detected using high-performance liquid chromatography photodiode array. Numerical analyses were performed on the NIR spectra to assess the usefulness of NIR to identify falsified and substandard medicines. The NIRS device was successful at detecting falsified medicines in all cases where the library contained both quality assured and falsified medicines of the same stated brand of medicines. The NIRS device was successful at identifying substandard amounts of artesunate but not amodiaquine in the ACT samples (N = 15) of artesunate-amodiaquine. This work reveals that this low-cost, portable NIRS device is promising for screening ACTs for falsified samples and could enable widespread drug screening at all points of the health system.

Authors+Show Affiliations

Intellectual Ventures Laboratory, Bellevue, Washington.London School of Hygiene and Tropical Medicine, London, United Kingdom.London School of Hygiene and Tropical Medicine, London, United Kingdom.Intellectual Ventures Laboratory, Bellevue, Washington.Intellectual Ventures Laboratory, Bellevue, Washington.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28219992

Citation

Wilson, Benjamin K., et al. "A New Handheld Device for the Detection of Falsified Medicines: Demonstration On Falsified Artemisinin-Based Therapies From the Field." The American Journal of Tropical Medicine and Hygiene, vol. 96, no. 5, 2017, pp. 1117-1123.
Wilson BK, Kaur H, Allan EL, et al. A New Handheld Device for the Detection of Falsified Medicines: Demonstration on Falsified Artemisinin-Based Therapies from the Field. Am J Trop Med Hyg. 2017;96(5):1117-1123.
Wilson, B. K., Kaur, H., Allan, E. L., Lozama, A., & Bell, D. (2017). A New Handheld Device for the Detection of Falsified Medicines: Demonstration on Falsified Artemisinin-Based Therapies from the Field. The American Journal of Tropical Medicine and Hygiene, 96(5), 1117-1123. https://doi.org/10.4269/ajtmh.16-0904
Wilson BK, et al. A New Handheld Device for the Detection of Falsified Medicines: Demonstration On Falsified Artemisinin-Based Therapies From the Field. Am J Trop Med Hyg. 2017;96(5):1117-1123. PubMed PMID: 28219992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A New Handheld Device for the Detection of Falsified Medicines: Demonstration on Falsified Artemisinin-Based Therapies from the Field. AU - Wilson,Benjamin K, AU - Kaur,Harparkash, AU - Allan,Elizabeth Louise, AU - Lozama,Anthony, AU - Bell,David, Y1 - 2017/05/13/ PY - 2017/2/22/pubmed PY - 2017/8/5/medline PY - 2017/2/22/entrez SP - 1117 EP - 1123 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 96 IS - 5 N2 - AbstractPoor-quality medicines are a major problem for health-care systems in resource-poor settings as identifying falsified medicines requires a complex laboratory infrastructure such as a Medicines Quality Control Laboratory. We report here an evaluation of a low-cost, handheld near-infrared spectrometer (NIRS) device by analyzing a library of artemisinin-based combination therapy (ACT) medicines to determine its usefulness as a drug-screening tool. The "SCiO" research prototype device was used to collect NIR spectra of a library of ACT and artesunate monotherapy medicine samples previously collected in Bioko Island and Equatorial Guinea and Kintampo, Ghana. The quality of these samples had been categorized as falsified, substandard, and quality assured based on the amount of stated active pharmaceutical ingredients detected using high-performance liquid chromatography photodiode array. Numerical analyses were performed on the NIR spectra to assess the usefulness of NIR to identify falsified and substandard medicines. The NIRS device was successful at detecting falsified medicines in all cases where the library contained both quality assured and falsified medicines of the same stated brand of medicines. The NIRS device was successful at identifying substandard amounts of artesunate but not amodiaquine in the ACT samples (N = 15) of artesunate-amodiaquine. This work reveals that this low-cost, portable NIRS device is promising for screening ACTs for falsified samples and could enable widespread drug screening at all points of the health system. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/28219992/A_New_Handheld_Device_for_the_Detection_of_Falsified_Medicines:_Demonstration_on_Falsified_Artemisinin_Based_Therapies_from_the_Field_ L2 - https://ajtmh.org/doi/10.4269/ajtmh.16-0904 DB - PRIME DP - Unbound Medicine ER -