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The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture.
Osteoporos Int 2017; 28(5):1641-1652OI

Abstract

In this meta-analysis, we evaluated the association between serum 25-hydroxyvitamin D (25(OH) vitamin D) level and the risk of total fractures and hip fractures. Low serum 25(OH) vitamin D level is associated with an increased risk of total and hip fractures.

INTRODUCTION

Data on the association between serum 25(OH) vitamin D level and the risk of fractures are conflicting. This study aimed to provide a summary of prospective cohort or nested case-control studies on the association between serum 25(OH) vitamin D level and the risk of total fractures and hip fractures.

METHODS

We identified relevant studies by searching the PubMed, EMBASE, and OVID databases from their inception to June 1, 2016. We included published prospective cohort or nested case-control studies evaluating the associations of serum 25(OH) vitamin D level with the fracture risk. Two reviewers abstracted the data independently. Relative risks (RRs) with 95% confidence intervals (CIs) were derived throughout the whole analysis.

RESULTS

Sixteen prospective cohort studies and three nested case-control studies were included. We found that low serum 25(OH) vitamin D level was significantly associated with the risk of total fractures (RR 1.25, 95% CI 1.06-1.43; I 2 = 31.3%, p for heterogeneity = 0.15) and hip fractures (RR 1.48, 95% CI 1.29-1.68; I 2 = 0%, p for heterogeneity = 0.51). The hip fracture risk was increased by 40% for each SD decrease in serum 25(OH) vitamin D level (RR 1.40, 95% CI 1.20-1.61; I 2 = 0%, p for heterogeneity = 0.51). The per SD decrease in serum 25(OH) vitamin D level was not associated with the increased risk of total fractures (RR 1.14, 95% CI 0.93-1.35; I 2 = 63.2%, p for heterogeneity = 0.04).

CONCLUSIONS

Our study suggests that low serum 25(OH) vitamin D level is associated with increased risks of total and hip fractures. In the analyzed studies, the per SD decrease in serum 25(OH) vitamin D level was associated with the hip fracture risk but not with the total fracture risk.

Authors+Show Affiliations

Department of Orthopedics, Ren Ji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.Department of Orthopedics, Ren Ji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.Department of Orthopedics, Ren Ji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.Department of Orthopedics, Ren Ji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China. drbinchan@gmail.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

28220196

Citation

Feng, Y, et al. "The Associations Between Serum 25-hydroxyvitamin D Level and the Risk of Total Fracture and Hip Fracture." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 28, no. 5, 2017, pp. 1641-1652.
Feng Y, Cheng G, Wang H, et al. The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture. Osteoporos Int. 2017;28(5):1641-1652.
Feng, Y., Cheng, G., Wang, H., & Chen, B. (2017). The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 28(5), pp. 1641-1652. doi:10.1007/s00198-017-3955-x.
Feng Y, et al. The Associations Between Serum 25-hydroxyvitamin D Level and the Risk of Total Fracture and Hip Fracture. Osteoporos Int. 2017;28(5):1641-1652. PubMed PMID: 28220196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture. AU - Feng,Y, AU - Cheng,G, AU - Wang,H, AU - Chen,B, Y1 - 2017/02/20/ PY - 2016/08/10/received PY - 2017/01/31/accepted PY - 2017/2/22/pubmed PY - 2017/10/17/medline PY - 2017/2/22/entrez KW - Cohort KW - Fracture KW - Meta-analysis KW - Serum 25(OH) vitamin D SP - 1641 EP - 1652 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 28 IS - 5 N2 - : In this meta-analysis, we evaluated the association between serum 25-hydroxyvitamin D (25(OH) vitamin D) level and the risk of total fractures and hip fractures. Low serum 25(OH) vitamin D level is associated with an increased risk of total and hip fractures. INTRODUCTION: Data on the association between serum 25(OH) vitamin D level and the risk of fractures are conflicting. This study aimed to provide a summary of prospective cohort or nested case-control studies on the association between serum 25(OH) vitamin D level and the risk of total fractures and hip fractures. METHODS: We identified relevant studies by searching the PubMed, EMBASE, and OVID databases from their inception to June 1, 2016. We included published prospective cohort or nested case-control studies evaluating the associations of serum 25(OH) vitamin D level with the fracture risk. Two reviewers abstracted the data independently. Relative risks (RRs) with 95% confidence intervals (CIs) were derived throughout the whole analysis. RESULTS: Sixteen prospective cohort studies and three nested case-control studies were included. We found that low serum 25(OH) vitamin D level was significantly associated with the risk of total fractures (RR 1.25, 95% CI 1.06-1.43; I 2 = 31.3%, p for heterogeneity = 0.15) and hip fractures (RR 1.48, 95% CI 1.29-1.68; I 2 = 0%, p for heterogeneity = 0.51). The hip fracture risk was increased by 40% for each SD decrease in serum 25(OH) vitamin D level (RR 1.40, 95% CI 1.20-1.61; I 2 = 0%, p for heterogeneity = 0.51). The per SD decrease in serum 25(OH) vitamin D level was not associated with the increased risk of total fractures (RR 1.14, 95% CI 0.93-1.35; I 2 = 63.2%, p for heterogeneity = 0.04). CONCLUSIONS: Our study suggests that low serum 25(OH) vitamin D level is associated with increased risks of total and hip fractures. In the analyzed studies, the per SD decrease in serum 25(OH) vitamin D level was associated with the hip fracture risk but not with the total fracture risk. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/28220196/The_associations_between_serum_25_hydroxyvitamin_D_level_and_the_risk_of_total_fracture_and_hip_fracture_ L2 - https://dx.doi.org/10.1007/s00198-017-3955-x DB - PRIME DP - Unbound Medicine ER -