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Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia.
Neuropsychiatr Dis Treat 2017; 13:397-406ND

Abstract

OBJECTIVE

Abnormal resting-state functional connectivity (FC), particularly in the default mode network (DMN) and the salience network (SN), has been reported in schizophrenia, but little is known about the effects of antipsychotics on these networks. The purpose of this study was to examine the effects of atypical antipsychotics on DMN and SN and the relationship between these effects and symptom improvement in patients with schizophrenia.

METHODS

This was a prospective study of 33 patients diagnosed with schizophrenia and treated with antipsychotics at Shanghai Mental Health Center. Thirty-three healthy controls matched for age and gender were recruited. All subjects underwent functional magnetic resonance imaging (fMRI). Healthy controls were scanned only once; patients were scanned before and after 6-8 weeks of treatment.

RESULTS

In the DMN, the patients exhibited increased FC after treatment in the right superior temporal gyrus, right medial frontal gyrus, and left superior frontal gyrus and decreased FC in the right posterior cingulate/precuneus (P<0.005). In the SN, the patients exhibited decreased FC in the right cerebellum anterior lobe and left insula (P<0.005). The FC in the right posterior cingulate/precuneus in the DMN negatively correlated with the difference between the Clinical Global Impression (CGI) score pre/post-treatment (r=-0.564, P=0.023) and negative trends with the difference in the Positive and Negative Syndrome Scale (PANSS) total score pre/post-treatment (r=-0.475, P=0.063) and the difference in PANSS-positive symptom scores (r=-0.481, P=0.060).

CONCLUSION

These findings suggest that atypical antipsychotics could regulate the FC of certain key brain regions within the DMN in early-phase schizophrenia, which might be related to symptom improvement. However, the effects of atypical antipsychotics on SN are less clear.

Authors+Show Affiliations

First-Episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine.Department of Radiology, Huashan Hospital, Fu Dan University, Shanghai, People's Republic of China.Psychotic Disorders Program, UMass Memorial Medical Center, UMass Medical School, Worcester, MA, USA.First-Episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine.Department of Radiology, Huashan Hospital, Fu Dan University, Shanghai, People's Republic of China.First-Episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine.First-Episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine.First-Episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine.First-Episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine.First-Episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28223812

Citation

Wang, Yingchan, et al. "Resting-state Functional Connectivity Changes Within the Default Mode Network and the Salience Network After Antipsychotic Treatment in Early-phase Schizophrenia." Neuropsychiatric Disease and Treatment, vol. 13, 2017, pp. 397-406.
Wang Y, Tang W, Fan X, et al. Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia. Neuropsychiatr Dis Treat. 2017;13:397-406.
Wang, Y., Tang, W., Fan, X., Zhang, J., Geng, D., Jiang, K., ... Liu, D. (2017). Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia. Neuropsychiatric Disease and Treatment, 13, pp. 397-406. doi:10.2147/NDT.S123598.
Wang Y, et al. Resting-state Functional Connectivity Changes Within the Default Mode Network and the Salience Network After Antipsychotic Treatment in Early-phase Schizophrenia. Neuropsychiatr Dis Treat. 2017;13:397-406. PubMed PMID: 28223812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resting-state functional connectivity changes within the default mode network and the salience network after antipsychotic treatment in early-phase schizophrenia. AU - Wang,Yingchan, AU - Tang,Weijun, AU - Fan,Xiaoduo, AU - Zhang,Jianye, AU - Geng,Daoying, AU - Jiang,Kaida, AU - Zhu,Dianming, AU - Song,Zhenhua, AU - Xiao,Zeping, AU - Liu,Dengtang, Y1 - 2017/02/07/ PY - 2017/2/23/entrez PY - 2017/2/23/pubmed PY - 2017/2/23/medline KW - antipsychotics KW - default network KW - fMRI KW - salience network KW - schizophrenia SP - 397 EP - 406 JF - Neuropsychiatric disease and treatment JO - Neuropsychiatr Dis Treat VL - 13 N2 - OBJECTIVE: Abnormal resting-state functional connectivity (FC), particularly in the default mode network (DMN) and the salience network (SN), has been reported in schizophrenia, but little is known about the effects of antipsychotics on these networks. The purpose of this study was to examine the effects of atypical antipsychotics on DMN and SN and the relationship between these effects and symptom improvement in patients with schizophrenia. METHODS: This was a prospective study of 33 patients diagnosed with schizophrenia and treated with antipsychotics at Shanghai Mental Health Center. Thirty-three healthy controls matched for age and gender were recruited. All subjects underwent functional magnetic resonance imaging (fMRI). Healthy controls were scanned only once; patients were scanned before and after 6-8 weeks of treatment. RESULTS: In the DMN, the patients exhibited increased FC after treatment in the right superior temporal gyrus, right medial frontal gyrus, and left superior frontal gyrus and decreased FC in the right posterior cingulate/precuneus (P<0.005). In the SN, the patients exhibited decreased FC in the right cerebellum anterior lobe and left insula (P<0.005). The FC in the right posterior cingulate/precuneus in the DMN negatively correlated with the difference between the Clinical Global Impression (CGI) score pre/post-treatment (r=-0.564, P=0.023) and negative trends with the difference in the Positive and Negative Syndrome Scale (PANSS) total score pre/post-treatment (r=-0.475, P=0.063) and the difference in PANSS-positive symptom scores (r=-0.481, P=0.060). CONCLUSION: These findings suggest that atypical antipsychotics could regulate the FC of certain key brain regions within the DMN in early-phase schizophrenia, which might be related to symptom improvement. However, the effects of atypical antipsychotics on SN are less clear. SN - 1176-6328 UR - https://www.unboundmedicine.com/medline/citation/28223812/Resting_state_functional_connectivity_changes_within_the_default_mode_network_and_the_salience_network_after_antipsychotic_treatment_in_early_phase_schizophrenia_ L2 - https://dx.doi.org/10.2147/NDT.S123598 DB - PRIME DP - Unbound Medicine ER -