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Divergent functions of the left and right central amygdala in visceral nociception.
Pain 2017; 158(4):747-759PAIN

Abstract

The left and right central amygdalae (CeA) are limbic regions involved in somatic and visceral pain processing. These 2 nuclei are asymmetrically involved in somatic pain modulation; pain-like responses on both sides of the body are preferentially driven by the right CeA, and in a reciprocal fashion, nociceptive somatic stimuli on both sides of the body predominantly alter molecular and physiological activities in the right CeA. Unknown, however, is whether this lateralization also exists in visceral pain processing and furthermore what function the left CeA has in modulating nociceptive information. Using urinary bladder distension (UBD) and excitatory optogenetics, a pronociceptive function of the right CeA was demonstrated in mice. Channelrhodopsin-2-mediated activation of the right CeA increased visceromotor responses (VMRs), while activation of the left CeA had no effect. Similarly, UBD-evoked VMRs increased after unilateral infusion of pituitary adenylate cyclase-activating polypeptide in the right CeA. To determine intrinsic left CeA involvement in bladder pain modulation, this region was optogenetically silenced during noxious UBD. Halorhodopsin (NpHR)-mediated inhibition of the left CeA increased VMRs, suggesting an ongoing antinociceptive function for this region. Finally, divergent left and right CeA functions were evaluated during abdominal mechanosensory testing. In naive animals, channelrhodopsin-2-mediated activation of the right CeA induced mechanical allodynia, and after cyclophosphamide-induced bladder sensitization, activation of the left CeA reversed referred bladder pain-like behaviors. Overall, these data provide evidence for functional brain lateralization in the absence of peripheral anatomical asymmetries.

Authors+Show Affiliations

Department of Biological Sciences and Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28225716

Citation

Sadler, Katelyn E., et al. "Divergent Functions of the Left and Right Central Amygdala in Visceral Nociception." Pain, vol. 158, no. 4, 2017, pp. 747-759.
Sadler KE, McQuaid NA, Cox AC, et al. Divergent functions of the left and right central amygdala in visceral nociception. Pain. 2017;158(4):747-759.
Sadler, K. E., McQuaid, N. A., Cox, A. C., Behun, M. N., Trouten, A. M., & Kolber, B. J. (2017). Divergent functions of the left and right central amygdala in visceral nociception. Pain, 158(4), pp. 747-759. doi:10.1097/j.pain.0000000000000830.
Sadler KE, et al. Divergent Functions of the Left and Right Central Amygdala in Visceral Nociception. Pain. 2017;158(4):747-759. PubMed PMID: 28225716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Divergent functions of the left and right central amygdala in visceral nociception. AU - Sadler,Katelyn E, AU - McQuaid,Neal A, AU - Cox,Abigail C, AU - Behun,Marissa N, AU - Trouten,Allison M, AU - Kolber,Benedict J, PY - 2017/2/23/pubmed PY - 2017/11/8/medline PY - 2017/2/23/entrez SP - 747 EP - 759 JF - Pain JO - Pain VL - 158 IS - 4 N2 - The left and right central amygdalae (CeA) are limbic regions involved in somatic and visceral pain processing. These 2 nuclei are asymmetrically involved in somatic pain modulation; pain-like responses on both sides of the body are preferentially driven by the right CeA, and in a reciprocal fashion, nociceptive somatic stimuli on both sides of the body predominantly alter molecular and physiological activities in the right CeA. Unknown, however, is whether this lateralization also exists in visceral pain processing and furthermore what function the left CeA has in modulating nociceptive information. Using urinary bladder distension (UBD) and excitatory optogenetics, a pronociceptive function of the right CeA was demonstrated in mice. Channelrhodopsin-2-mediated activation of the right CeA increased visceromotor responses (VMRs), while activation of the left CeA had no effect. Similarly, UBD-evoked VMRs increased after unilateral infusion of pituitary adenylate cyclase-activating polypeptide in the right CeA. To determine intrinsic left CeA involvement in bladder pain modulation, this region was optogenetically silenced during noxious UBD. Halorhodopsin (NpHR)-mediated inhibition of the left CeA increased VMRs, suggesting an ongoing antinociceptive function for this region. Finally, divergent left and right CeA functions were evaluated during abdominal mechanosensory testing. In naive animals, channelrhodopsin-2-mediated activation of the right CeA induced mechanical allodynia, and after cyclophosphamide-induced bladder sensitization, activation of the left CeA reversed referred bladder pain-like behaviors. Overall, these data provide evidence for functional brain lateralization in the absence of peripheral anatomical asymmetries. SN - 1872-6623 UR - https://www.unboundmedicine.com/medline/citation/28225716/Divergent_functions_of_the_left_and_right_central_amygdala_in_visceral_nociception_ L2 - http://Insights.ovid.com/pubmed?pmid=28225716 DB - PRIME DP - Unbound Medicine ER -