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Comparative microscopic analysis of nail clippings from patients with cutaneous psoriasis and psoriatic arthritis.
An Bras Dermatol. 2017 Jan-Feb; 92(1):21-25.AB

Abstract

BACKGROUND:

The nail involvement in psoriasis is related to psoriatic arthritis and may represent a predictor of the disease.

OBJECTIVES:

To analyze, through nail clipping, clinically normal and dystrophic nails of patients with cutaneous psoriasis and psoriatic arthritis.

METHODS:

This is a cross-sectional multicenter study, conducted between August 2011 and March 2012. Patients were divided into four groups: patients with cutaneous psoriasis and onychodystrophy, patients with cutaneous psoriasis and clinically normal nails, patients with psoriatic arthritis and onychodystrophy and patients with psoriatic arthritis and clinically normal nails. We calculated NAPSI (Nail Psoriasis Severity Index) of the nail with more clinically noticeable change. After collection and preparation of the nail clipping, the following microscopic parameters were evaluated: thickness of the nail plate and subungual region, presence or absence of parakeratosis, serous lakes, blood, and fungi.

RESULTS:

There were more layers of parakeratosis (p=0.001) and a greater thickness of the subungual region in patients with cutaneous psoriasis and onychodystrophy (p=0.002). Serous lakes were also more present in the same group (p=0.008) and in patients with psoriatic arthritis and normal nails (p=0.047). The other microscopic parameters showed no significant difference between normal and dystrophic nails or between patients with psoriatic arthritis or cutaneous psoriasis.

STUDY LIMITATIONS:

Small sample size and use of medications.

CONCLUSIONS:

Nail clipping is a simple and quick method to assess the nails of patients with nail psoriasis although does not demonstrate difference between those with joint changes or exclusively cutaneous psoriasis.

Authors+Show Affiliations

Private Clinic - Vacaria (RS), Brazil.Dermatology and Pathology Departments of the Universidade Federal do Paraná (UFPR) - Curitiba (PR), Brazil.Private Clinic - Campo Largo (PR), Brazil.Department of Rheumatology of the Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) - Porto Alegre (RS), Brazil.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

28225951

Citation

Fonseca, Gabriela Poglia, et al. "Comparative Microscopic Analysis of Nail Clippings From Patients With Cutaneous Psoriasis and Psoriatic Arthritis." Anais Brasileiros De Dermatologia, vol. 92, no. 1, 2017, pp. 21-25.
Fonseca GP, Werner B, Seidel G, et al. Comparative microscopic analysis of nail clippings from patients with cutaneous psoriasis and psoriatic arthritis. An Bras Dermatol. 2017;92(1):21-25.
Fonseca, G. P., Werner, B., Seidel, G., & Staub, H. L. (2017). Comparative microscopic analysis of nail clippings from patients with cutaneous psoriasis and psoriatic arthritis. Anais Brasileiros De Dermatologia, 92(1), 21-25. https://doi.org/10.1590/abd1806-4841.20175056
Fonseca GP, et al. Comparative Microscopic Analysis of Nail Clippings From Patients With Cutaneous Psoriasis and Psoriatic Arthritis. An Bras Dermatol. 2017 Jan-Feb;92(1):21-25. PubMed PMID: 28225951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative microscopic analysis of nail clippings from patients with cutaneous psoriasis and psoriatic arthritis. AU - Fonseca,Gabriela Poglia, AU - Werner,Betina, AU - Seidel,Gabriela, AU - Staub,Henrique Luiz, PY - 2015/08/19/received PY - 2016/03/05/accepted PY - 2017/2/23/entrez PY - 2017/2/23/pubmed PY - 2017/10/5/medline SP - 21 EP - 25 JF - Anais brasileiros de dermatologia JO - An Bras Dermatol VL - 92 IS - 1 N2 - BACKGROUND:: The nail involvement in psoriasis is related to psoriatic arthritis and may represent a predictor of the disease. OBJECTIVES:: To analyze, through nail clipping, clinically normal and dystrophic nails of patients with cutaneous psoriasis and psoriatic arthritis. METHODS:: This is a cross-sectional multicenter study, conducted between August 2011 and March 2012. Patients were divided into four groups: patients with cutaneous psoriasis and onychodystrophy, patients with cutaneous psoriasis and clinically normal nails, patients with psoriatic arthritis and onychodystrophy and patients with psoriatic arthritis and clinically normal nails. We calculated NAPSI (Nail Psoriasis Severity Index) of the nail with more clinically noticeable change. After collection and preparation of the nail clipping, the following microscopic parameters were evaluated: thickness of the nail plate and subungual region, presence or absence of parakeratosis, serous lakes, blood, and fungi. RESULTS:: There were more layers of parakeratosis (p=0.001) and a greater thickness of the subungual region in patients with cutaneous psoriasis and onychodystrophy (p=0.002). Serous lakes were also more present in the same group (p=0.008) and in patients with psoriatic arthritis and normal nails (p=0.047). The other microscopic parameters showed no significant difference between normal and dystrophic nails or between patients with psoriatic arthritis or cutaneous psoriasis. STUDY LIMITATIONS:: Small sample size and use of medications. CONCLUSIONS:: Nail clipping is a simple and quick method to assess the nails of patients with nail psoriasis although does not demonstrate difference between those with joint changes or exclusively cutaneous psoriasis. SN - 1806-4841 UR - https://www.unboundmedicine.com/medline/citation/28225951/Comparative_microscopic_analysis_of_nail_clippings_from_patients_with_cutaneous_psoriasis_and_psoriatic_arthritis_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28225951/ DB - PRIME DP - Unbound Medicine ER -