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Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review.
Arch Endocrinol Metab. 2017 Mar-Apr; 61(2):198-201.AE

Abstract

Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels. However, the safety and efficacy of heparin and insulin in the treatment of hypertriglyceridemia-associated acute pancreatitis have not been well established yet. We successfully used heparin and insulin as first-line therapy in four consecutive patients with acute pancreatitis secondary to hypertriglyceridemia. In a literature search, we revised almost all reports published to date of patients managed successfully with this combination. Heparin and insulin appear to be a safe, effective, and inexpensive first-line therapy for hypertriglyceridemia-associated acute pancreatitis.

Authors+Show Affiliations

Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India.Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India.Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India.Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India.Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India.Division of Endocrinology and Diabetes, Medanta - The Medicity, Gurgaon, Haryana, India.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

28225998

Citation

Kuchay, Mohammad Shafi, et al. "Heparin and Insulin in the Management of Hypertriglyceridemia-associated Pancreatitis: Case Series and Literature Review." Archives of Endocrinology and Metabolism, vol. 61, no. 2, 2017, pp. 198-201.
Kuchay MS, Farooqui KJ, Bano T, et al. Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review. Arch Endocrinol Metab. 2017;61(2):198-201.
Kuchay, M. S., Farooqui, K. J., Bano, T., Khandelwal, M., Gill, H., & Mithal, A. (2017). Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review. Archives of Endocrinology and Metabolism, 61(2), 198-201. https://doi.org/10.1590/2359-3997000000244
Kuchay MS, et al. Heparin and Insulin in the Management of Hypertriglyceridemia-associated Pancreatitis: Case Series and Literature Review. Arch Endocrinol Metab. 2017 Mar-Apr;61(2):198-201. PubMed PMID: 28225998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heparin and insulin in the management of hypertriglyceridemia-associated pancreatitis: case series and literature review. AU - Kuchay,Mohammad Shafi, AU - Farooqui,Khalid J, AU - Bano,Tarannum, AU - Khandelwal,Manoj, AU - Gill,Harmandeep, AU - Mithal,Ambrish, Y1 - 2017/02/13/ PY - 2016/05/19/received PY - 2016/10/18/accepted PY - 2017/2/23/pubmed PY - 2017/9/7/medline PY - 2017/2/23/entrez SP - 198 EP - 201 JF - Archives of endocrinology and metabolism JO - Arch Endocrinol Metab VL - 61 IS - 2 N2 - Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels. However, the safety and efficacy of heparin and insulin in the treatment of hypertriglyceridemia-associated acute pancreatitis have not been well established yet. We successfully used heparin and insulin as first-line therapy in four consecutive patients with acute pancreatitis secondary to hypertriglyceridemia. In a literature search, we revised almost all reports published to date of patients managed successfully with this combination. Heparin and insulin appear to be a safe, effective, and inexpensive first-line therapy for hypertriglyceridemia-associated acute pancreatitis. SN - 2359-4292 UR - https://www.unboundmedicine.com/medline/citation/28225998/Heparin_and_insulin_in_the_management_of_hypertriglyceridemia_associated_pancreatitis:_case_series_and_literature_review_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017005001112&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -