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Fruit and vegetable consumption and risk of COPD: a prospective cohort study of men.
Thorax. 2017 06; 72(6):500-509.T

Abstract

BACKGROUND

Antioxidants present in fruits and vegetables may protect the lung from oxidative damage and prevent COPD.

AIMS

To determine the association between fruit and vegetable consumption and risk of COPD by smoking status in men.

METHODS

The population-based prospective Cohort of Swedish Men included 44 335 men, aged 45-79 years, with no history of COPD at baseline. Fruit and vegetable consumption was assessed with a self-administered questionnaire.

RESULTS

During a mean follow-up of 13.2 years, 1918 incident cases of COPD were ascertained. A strong inverse association between total fruit and vegetable consumption and COPD was observed in smokers but not in never-smokers (p-interaction=0.02). The age-standardised incidence rate per 100 000 person-years in the lowest quintile (<2 servings/day) of total fruit and vegetable consumption was 1166 in current smokers and 506 in ex-smokers; among those in the highest quintile (≥5.3 servings/day), 546 and 255 per 100 000 person-years, respectively. The multivariable HR of COPD comparing extreme quintiles of total fruit and vegetable consumption was 0.60 (95% CI 0.47 to 0.76, p-trend <0.0001) in current smokers and 0.66 (95% CI 0.51 to 0.85, p-trend=0.001) in ex-smokers. Each one serving per day increment in total fruit and vegetable consumption decreased risk of COPD significantly by 8% (95% CI 4% to 11%) in current smokers and by 4% (95% CI 0% to 7%) in ex-smokers.

CONCLUSIONS

These results indicate that high consumption of fruits and vegetables is associated with reduced COPD incidence in both current and ex-smokers but not in never-smokers.

Authors+Show Affiliations

Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Human Nutrition, Warsaw University of Life Sciences-SGGW, Warsaw, Poland.Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28228486

Citation

Kaluza, Joanna, et al. "Fruit and Vegetable Consumption and Risk of COPD: a Prospective Cohort Study of Men." Thorax, vol. 72, no. 6, 2017, pp. 500-509.
Kaluza J, Larsson SC, Orsini N, et al. Fruit and vegetable consumption and risk of COPD: a prospective cohort study of men. Thorax. 2017;72(6):500-509.
Kaluza, J., Larsson, S. C., Orsini, N., Linden, A., & Wolk, A. (2017). Fruit and vegetable consumption and risk of COPD: a prospective cohort study of men. Thorax, 72(6), 500-509. https://doi.org/10.1136/thoraxjnl-2015-207851
Kaluza J, et al. Fruit and Vegetable Consumption and Risk of COPD: a Prospective Cohort Study of Men. Thorax. 2017;72(6):500-509. PubMed PMID: 28228486.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruit and vegetable consumption and risk of COPD: a prospective cohort study of men. AU - Kaluza,Joanna, AU - Larsson,Susanna C, AU - Orsini,Nicola, AU - Linden,Anders, AU - Wolk,Alicja, Y1 - 2017/02/22/ PY - 2015/09/17/received PY - 2016/11/07/revised PY - 2016/11/08/accepted PY - 2017/2/24/pubmed PY - 2017/8/2/medline PY - 2017/2/24/entrez KW - COPD epidemiology SP - 500 EP - 509 JF - Thorax JO - Thorax VL - 72 IS - 6 N2 - BACKGROUND: Antioxidants present in fruits and vegetables may protect the lung from oxidative damage and prevent COPD. AIMS: To determine the association between fruit and vegetable consumption and risk of COPD by smoking status in men. METHODS: The population-based prospective Cohort of Swedish Men included 44 335 men, aged 45-79 years, with no history of COPD at baseline. Fruit and vegetable consumption was assessed with a self-administered questionnaire. RESULTS: During a mean follow-up of 13.2 years, 1918 incident cases of COPD were ascertained. A strong inverse association between total fruit and vegetable consumption and COPD was observed in smokers but not in never-smokers (p-interaction=0.02). The age-standardised incidence rate per 100 000 person-years in the lowest quintile (<2 servings/day) of total fruit and vegetable consumption was 1166 in current smokers and 506 in ex-smokers; among those in the highest quintile (≥5.3 servings/day), 546 and 255 per 100 000 person-years, respectively. The multivariable HR of COPD comparing extreme quintiles of total fruit and vegetable consumption was 0.60 (95% CI 0.47 to 0.76, p-trend <0.0001) in current smokers and 0.66 (95% CI 0.51 to 0.85, p-trend=0.001) in ex-smokers. Each one serving per day increment in total fruit and vegetable consumption decreased risk of COPD significantly by 8% (95% CI 4% to 11%) in current smokers and by 4% (95% CI 0% to 7%) in ex-smokers. CONCLUSIONS: These results indicate that high consumption of fruits and vegetables is associated with reduced COPD incidence in both current and ex-smokers but not in never-smokers. SN - 1468-3296 UR - https://www.unboundmedicine.com/medline/citation/28228486/Fruit_and_vegetable_consumption_and_risk_of_COPD:_a_prospective_cohort_study_of_men_ L2 - http://thorax.bmj.com/cgi/pmidlookup?view=long&amp;pmid=28228486 DB - PRIME DP - Unbound Medicine ER -