Tags

Type your tag names separated by a space and hit enter

Coenzyme Q10 does not prevent exercise-induced muscle damage and oxidative stress in sedentary men.
J Sports Med Phys Fitness. 2018 Jun; 58(6):889-894.JS

Abstract

BACKGROUND

The objective of this study was to examine the effects of coenzyme Q10 (CoQ10) supplementation on exercise-induced muscle damage and oxidative stress in sedentary young men. In this study, a total of 21 sedentary and healthy young men participated.

METHODS

Participants were assigned at random to a CoQ10 or a placebo group employing a double-blind method. Those in the CoQ10 group ingested 200 mg CoQ10 per day for 4 weeks. Those in the placebo group ingested the same dosage of a placebo. After the 4-week period, the same measurements and blood sampling were taken. At this point, eccentric exercise protocols (90° flexion and 180° extension, velocity 60°/s) were instigated for all subjects in isokinetic exercise dynamometry. After exercise, blood samples were taken immediately, 24, and 48 hours later. Blood samples were analyzed for plasma CoQ10 levels, serum creatine kinase (CK) activities, myoglobin (Mb) levels, plasma total superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels.

RESULTS

Plasma CoQ10 levels were higher in the CoQ10 supplemented group than in the placebo group (P<0.05). CK activities and levels of Mb increased in both groups 24 and 48 hours after exercise (P<0.05), but no significant difference between the groups was observed (P>0.05). Plasma total SOD activity and MDA levels were not significantly different in both groups 24 and 48 hours after exercise (P>0.05).

CONCLUSIONS

CoQ10 supplementation does not prevent exercise induced muscle damage and oxidative stress in sedentary young men.

Authors+Show Affiliations

Division of Sports Physiology, Department of Physiology, Faculty of Medicine, Selçuk University, Konya, Turkey.Division of Sports Physiology, Department of Physiology, Faculty of Medicine, Selçuk University, Konya, Turkey - mbelviranli@yahoo.com.Division of Sports Physiology, Department of Physiology, Faculty of Medicine, Selçuk University, Konya, Turkey.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28229572

Citation

Okudan, Nilsel, et al. "Coenzyme Q10 Does Not Prevent Exercise-induced Muscle Damage and Oxidative Stress in Sedentary Men." The Journal of Sports Medicine and Physical Fitness, vol. 58, no. 6, 2018, pp. 889-894.
Okudan N, Belviranli M, Torlak S. Coenzyme Q10 does not prevent exercise-induced muscle damage and oxidative stress in sedentary men. J Sports Med Phys Fitness. 2018;58(6):889-894.
Okudan, N., Belviranli, M., & Torlak, S. (2018). Coenzyme Q10 does not prevent exercise-induced muscle damage and oxidative stress in sedentary men. The Journal of Sports Medicine and Physical Fitness, 58(6), 889-894. https://doi.org/10.23736/S0022-4707.17.07146-8
Okudan N, Belviranli M, Torlak S. Coenzyme Q10 Does Not Prevent Exercise-induced Muscle Damage and Oxidative Stress in Sedentary Men. J Sports Med Phys Fitness. 2018;58(6):889-894. PubMed PMID: 28229572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coenzyme Q10 does not prevent exercise-induced muscle damage and oxidative stress in sedentary men. AU - Okudan,Nilsel, AU - Belviranli,Muaz, AU - Torlak,Savaş, Y1 - 2017/02/22/ PY - 2017/2/24/pubmed PY - 2018/9/22/medline PY - 2017/2/24/entrez SP - 889 EP - 894 JF - The Journal of sports medicine and physical fitness JO - J Sports Med Phys Fitness VL - 58 IS - 6 N2 - BACKGROUND: The objective of this study was to examine the effects of coenzyme Q10 (CoQ10) supplementation on exercise-induced muscle damage and oxidative stress in sedentary young men. In this study, a total of 21 sedentary and healthy young men participated. METHODS: Participants were assigned at random to a CoQ10 or a placebo group employing a double-blind method. Those in the CoQ10 group ingested 200 mg CoQ10 per day for 4 weeks. Those in the placebo group ingested the same dosage of a placebo. After the 4-week period, the same measurements and blood sampling were taken. At this point, eccentric exercise protocols (90° flexion and 180° extension, velocity 60°/s) were instigated for all subjects in isokinetic exercise dynamometry. After exercise, blood samples were taken immediately, 24, and 48 hours later. Blood samples were analyzed for plasma CoQ10 levels, serum creatine kinase (CK) activities, myoglobin (Mb) levels, plasma total superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels. RESULTS: Plasma CoQ10 levels were higher in the CoQ10 supplemented group than in the placebo group (P<0.05). CK activities and levels of Mb increased in both groups 24 and 48 hours after exercise (P<0.05), but no significant difference between the groups was observed (P>0.05). Plasma total SOD activity and MDA levels were not significantly different in both groups 24 and 48 hours after exercise (P>0.05). CONCLUSIONS: CoQ10 supplementation does not prevent exercise induced muscle damage and oxidative stress in sedentary young men. SN - 1827-1928 UR - https://www.unboundmedicine.com/medline/citation/28229572/Coenzyme_Q10_does_not_prevent_exercise_induced_muscle_damage_and_oxidative_stress_in_sedentary_men_ L2 - https://www.minervamedica.it/index2.t?show=R40Y2018N06A0889 DB - PRIME DP - Unbound Medicine ER -