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Helicobacter pylori infection and pancreatic cancer risk: A meta-analysis.
J Cancer Res Ther. 2016 Dec; 12(Supplement):C229-C232.JC

Abstract

OBJECTIVE

To assess whether the Helicobacter pylori (HP) infection can increase the risk of developing pancreatic cancer or not by meta-analysis.

METHODS

Published studies about HP infection and pancreatic cancer risk were electronic searched in the databases of MEDLINE, PubMed, Web of Science, and CNKI. The correlation between HP infection and pancreatic cancer was demonstrated by odds ratio (OR) and corresponding 95% confidence interval (CI). The publication bias was assessed by Begg's funnel plot and Egger's linear regression test.

RESULTS

We finally included eight case-control studies for this present meta-analysis with 1003 pancreatic cancer patients and 1754 healthy controls. One study performed in Austria, 3 from China, and 4 from the United States. For obvious statistical heterogeneity, the data were pooled by random effects model. The pooled data indicated that significant correlation between HP infection and pancreatic cancer was found with OR = 1.45 (95% CI = 1.09-1.92) under the random effects model. The results indicated that the HP infection can significantly increase the risk of developing pancreatic cancer. The publication bias was evaluated by Begg's funnel plot and Egger's linear regression test. The Begg's funnel plot was significant asymmetric at the bottom which indicated potential publication bias. The Egger's linear regression test also indicated significant publication bias (t = 3.21, P < 0.05).

CONCLUSION

Based on present open published data, HP infection can significantly increase the risk of developing pancreatic cancer. However, for small number of studies included in this meta-analysis and publication bias, more case-control or cohort studies are needed to further confirm this conclusion.

Authors+Show Affiliations

Department of Clinical Laboratory, Beijing Jishuitan Hospital, Beijing, P.R. China.Department of Clinical Laboratory, Beijing Jishuitan Hospital, Beijing, P.R. China.Department of Clinical Laboratory, Beijing Jishuitan Hospital, Beijing, P.R. China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

28230023

Citation

Guo, Yu, et al. "Helicobacter Pylori Infection and Pancreatic Cancer Risk: a Meta-analysis." Journal of Cancer Research and Therapeutics, vol. 12, no. Supplement, 2016, pp. C229-C232.
Guo Y, Liu W, Wu J. Helicobacter pylori infection and pancreatic cancer risk: A meta-analysis. J Cancer Res Ther. 2016;12(Supplement):C229-C232.
Guo, Y., Liu, W., & Wu, J. (2016). Helicobacter pylori infection and pancreatic cancer risk: A meta-analysis. Journal of Cancer Research and Therapeutics, 12(Supplement), C229-C232. https://doi.org/10.4103/0973-1482.200744
Guo Y, Liu W, Wu J. Helicobacter Pylori Infection and Pancreatic Cancer Risk: a Meta-analysis. J Cancer Res Ther. 2016;12(Supplement):C229-C232. PubMed PMID: 28230023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection and pancreatic cancer risk: A meta-analysis. AU - Guo,Yu, AU - Liu,Wei, AU - Wu,Jun, PY - 2017/2/24/entrez PY - 2017/2/24/pubmed PY - 2017/3/17/medline SP - C229 EP - C232 JF - Journal of cancer research and therapeutics JO - J Cancer Res Ther VL - 12 IS - Supplement N2 - OBJECTIVE: To assess whether the Helicobacter pylori (HP) infection can increase the risk of developing pancreatic cancer or not by meta-analysis. METHODS: Published studies about HP infection and pancreatic cancer risk were electronic searched in the databases of MEDLINE, PubMed, Web of Science, and CNKI. The correlation between HP infection and pancreatic cancer was demonstrated by odds ratio (OR) and corresponding 95% confidence interval (CI). The publication bias was assessed by Begg's funnel plot and Egger's linear regression test. RESULTS: We finally included eight case-control studies for this present meta-analysis with 1003 pancreatic cancer patients and 1754 healthy controls. One study performed in Austria, 3 from China, and 4 from the United States. For obvious statistical heterogeneity, the data were pooled by random effects model. The pooled data indicated that significant correlation between HP infection and pancreatic cancer was found with OR = 1.45 (95% CI = 1.09-1.92) under the random effects model. The results indicated that the HP infection can significantly increase the risk of developing pancreatic cancer. The publication bias was evaluated by Begg's funnel plot and Egger's linear regression test. The Begg's funnel plot was significant asymmetric at the bottom which indicated potential publication bias. The Egger's linear regression test also indicated significant publication bias (t = 3.21, P < 0.05). CONCLUSION: Based on present open published data, HP infection can significantly increase the risk of developing pancreatic cancer. However, for small number of studies included in this meta-analysis and publication bias, more case-control or cohort studies are needed to further confirm this conclusion. SN - 1998-4138 UR - https://www.unboundmedicine.com/medline/citation/28230023/Helicobacter_pylori_infection_and_pancreatic_cancer_risk:_A_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -