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Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals.
Int J Pharm. 2017 Apr 15; 521(1-2):374-383.IJ

Abstract

Punch sticking is a frequently occurring problem that challenges successful tablet manufacturing. A mechanistic understanding of the punch sticking phenomenon facilitates the design of effective strategies to solve punch sticking problems of a drug. The first step in this effort is to identify process parameters and particle properties that can profoundly affect sticking performance. This work was aimed at elucidating the key material properties and compaction parameters that influence punch sticking by statistically analyzing punch sticking data of 24 chemically diverse compounds obtained using a set of tooling with removable upper punch tip. Partial least square (PLS) analysis of the data revealed that particle surface area and tablet tensile strength are the most significant factors attributed to punch sticking. Die-wall pressure, ejection force, and take-off force also correlate with sticking, but to a lesser extent.

Authors+Show Affiliations

Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127 B Weaver-Densford Hall,308 Harvard Street S.E., Minneapolis, MN 55455, United States.Pfizer Worldwide Research & Development,Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom.Pfizer Worldwide Research & Development, Groton, CT, 06340, United States.Pfizer Worldwide Research & Development, Groton, CT, 06340, United States.Pfizer Worldwide Research & Development,Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom.Pfizer Worldwide Research & Development, Groton, CT, 06340, United States.Pfizer Worldwide Research & Development, Groton, CT, 06340, United States.Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 9-127 B Weaver-Densford Hall,308 Harvard Street S.E., Minneapolis, MN 55455, United States. Electronic address: sunx0053@umn.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28232264

Citation

Paul, Shubhajit, et al. "Powder Properties and Compaction Parameters That Influence Punch Sticking Propensity of Pharmaceuticals." International Journal of Pharmaceutics, vol. 521, no. 1-2, 2017, pp. 374-383.
Paul S, Taylor LJ, Murphy B, et al. Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals. Int J Pharm. 2017;521(1-2):374-383.
Paul, S., Taylor, L. J., Murphy, B., Krzyzaniak, J. F., Dawson, N., Mullarney, M. P., Meenan, P., & Sun, C. C. (2017). Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals. International Journal of Pharmaceutics, 521(1-2), 374-383. https://doi.org/10.1016/j.ijpharm.2017.02.053
Paul S, et al. Powder Properties and Compaction Parameters That Influence Punch Sticking Propensity of Pharmaceuticals. Int J Pharm. 2017 Apr 15;521(1-2):374-383. PubMed PMID: 28232264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Powder properties and compaction parameters that influence punch sticking propensity of pharmaceuticals. AU - Paul,Shubhajit, AU - Taylor,Lisa J, AU - Murphy,Brendan, AU - Krzyzaniak,Joseph F, AU - Dawson,Neil, AU - Mullarney,Matthew P, AU - Meenan,Paul, AU - Sun,Changquan Calvin, Y1 - 2017/02/21/ PY - 2016/10/19/received PY - 2017/01/31/revised PY - 2017/02/19/accepted PY - 2017/2/25/pubmed PY - 2017/8/18/medline PY - 2017/2/25/entrez KW - Linear regression KW - PLS analysis KW - Powder compaction KW - Sticking KW - Surface area KW - Tensile strength SP - 374 EP - 383 JF - International journal of pharmaceutics JO - Int J Pharm VL - 521 IS - 1-2 N2 - Punch sticking is a frequently occurring problem that challenges successful tablet manufacturing. A mechanistic understanding of the punch sticking phenomenon facilitates the design of effective strategies to solve punch sticking problems of a drug. The first step in this effort is to identify process parameters and particle properties that can profoundly affect sticking performance. This work was aimed at elucidating the key material properties and compaction parameters that influence punch sticking by statistically analyzing punch sticking data of 24 chemically diverse compounds obtained using a set of tooling with removable upper punch tip. Partial least square (PLS) analysis of the data revealed that particle surface area and tablet tensile strength are the most significant factors attributed to punch sticking. Die-wall pressure, ejection force, and take-off force also correlate with sticking, but to a lesser extent. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/28232264/Powder_properties_and_compaction_parameters_that_influence_punch_sticking_propensity_of_pharmaceuticals_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(17)30143-6 DB - PRIME DP - Unbound Medicine ER -