Tags

Type your tag names separated by a space and hit enter

Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography.
Skin Appendage Disord 2017; 2(3-4):102-108SA

Abstract

BACKGROUND

Nail psoriasis is a painful and disfiguring nail disease that often leads to invasive biopsies. Dermoscopy of the hyponychium can be useful in the diagnosis showing twisted coiled vessels. Structural features of nail psoriasis have been described with optical coherence tomography (OCT).

OBJECTIVES

To investigate vascular features of nail psoriasis using dynamic OCT.

METHODS

This was an observational, prospective, controlled study in which psoriasis patients with psoriatic nail changes and healthy control patients underwent OCT imaging of the distal nail plate and proximal nail fold. Vertical and horizontal OCT images were analyzed to describe structural and vascular features and to quantify blood flow at depth.

RESULTS

Sixteen psoriatic nails and 16 control nails were included. Psoriatic nails had significantly increased blood flow in the proximal nail fold at depths of 0.72 mm (p = 0.035) and 0.76 mm (p = 0.027). Nail thickness was significantly greater in psoriatic nails compared to control nails (p = 0.0016). Compared to control nails, psoriatic nails had dilated, disorganized blood vessels superficially in the proximal nail fold.

LIMITATIONS

The main limitation of our study is the relatively small sample size.

CONCLUSIONS

OCT can identify structural and vascular features specific to nail psoriasis.

Authors+Show Affiliations

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla., USA.Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla., USA.Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla., USA.Michelson Diagnostics Ltd, Maidstone, UK.Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla., USA.Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla., USA.Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla., USA.Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla., USA.Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fla., USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28232916

Citation

Aldahan, Adam S., et al. "Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography." Skin Appendage Disorders, vol. 2, no. 3-4, 2017, pp. 102-108.
Aldahan AS, Chen LL, Fertig RM, et al. Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography. Skin Appendage Disord. 2017;2(3-4):102-108.
Aldahan, A. S., Chen, L. L., Fertig, R. M., Holmes, J., Shah, V. V., Mlacker, S., ... Tosti, A. (2017). Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography. Skin Appendage Disorders, 2(3-4), pp. 102-108. doi:10.1159/000449230.
Aldahan AS, et al. Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography. Skin Appendage Disord. 2017;2(3-4):102-108. PubMed PMID: 28232916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography. AU - Aldahan,Adam S, AU - Chen,Lucy L, AU - Fertig,Raymond M, AU - Holmes,Jon, AU - Shah,Vidhi V, AU - Mlacker,Stephanie, AU - Hsu,Vincent M, AU - Nouri,Keyvan, AU - Tosti,Antonella, Y1 - 2016/09/21/ PY - 2016/08/10/received PY - 2016/08/17/accepted PY - 2017/2/25/entrez PY - 2017/2/25/pubmed PY - 2017/2/25/medline KW - Nail psoriasis KW - Nails KW - Optical coherence tomography KW - Optical imaging KW - Psoriasis KW - Vascular pattern SP - 102 EP - 108 JF - Skin appendage disorders JO - Skin Appendage Disord VL - 2 IS - 3-4 N2 - BACKGROUND: Nail psoriasis is a painful and disfiguring nail disease that often leads to invasive biopsies. Dermoscopy of the hyponychium can be useful in the diagnosis showing twisted coiled vessels. Structural features of nail psoriasis have been described with optical coherence tomography (OCT). OBJECTIVES: To investigate vascular features of nail psoriasis using dynamic OCT. METHODS: This was an observational, prospective, controlled study in which psoriasis patients with psoriatic nail changes and healthy control patients underwent OCT imaging of the distal nail plate and proximal nail fold. Vertical and horizontal OCT images were analyzed to describe structural and vascular features and to quantify blood flow at depth. RESULTS: Sixteen psoriatic nails and 16 control nails were included. Psoriatic nails had significantly increased blood flow in the proximal nail fold at depths of 0.72 mm (p = 0.035) and 0.76 mm (p = 0.027). Nail thickness was significantly greater in psoriatic nails compared to control nails (p = 0.0016). Compared to control nails, psoriatic nails had dilated, disorganized blood vessels superficially in the proximal nail fold. LIMITATIONS: The main limitation of our study is the relatively small sample size. CONCLUSIONS: OCT can identify structural and vascular features specific to nail psoriasis. SN - 2296-9195 UR - https://www.unboundmedicine.com/medline/citation/28232916/Vascular_Features_of_Nail_Psoriasis_Using_Dynamic_Optical_Coherence_Tomography L2 - https://www.karger.com?DOI=10.1159/000449230 DB - PRIME DP - Unbound Medicine ER -