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Increasing Risk of Disturbed Root Development in Permanent Teeth in Childhood Cancer Survivors Undergoing Cancer Treatment at Older Age.
J Pediatr Hematol Oncol. 2017 04; 39(3):e150-e154.JP

Abstract

BACKGROUND

Structural anomalies of teeth are observed at high rates in childhood cancer survivors (CCS). Several therapeutic exposures have been shown to be associated with dental developmental disturbances. This study was conducted to analyze the risk factors for dental developmental abnormality (DDA) and investigate the association between age at the time of cancer treatment and DDA in CCS.

PATIENTS AND METHODS

Fifty-six CCS were enrolled. Orthopantomography and dental examination were performed in all the patients. We evaluated the prevalence of DDA and analyzed the risk factors for each type of DDA.

RESULTS

DDAs were observed in 46.4% of CCS, including hypodontia in 9 (16.1%), abnormal roots in nine (16.1%), enamel defects/hypoplasia in 6 (10.7%), and microdontia in 12 (21.4%) patients. The number of patients with abnormal roots was significantly higher in the group treated with stem cell transplantation or at an age older than 4 years. We observed that the formation period of abnormal teeth coincided with the treatment period in the majority of CCS with DDA.

CONCLUSIONS

Particularly regarding the root abnormality, treatment at elder age may be a risk factor for root developmental disturbances. Risk evaluation, appropriate follow-up, and early detection of dental issues are required for all CCS.

Authors+Show Affiliations

Departments of *Pediatrics †Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto ‡Department of Hematology and Oncology, Nagano Children's Hospital, Azumino §Department of Pediatrics, School of Dentistry, Matsumoto Dental University, Shiojiri, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28234739

Citation

Tanaka, Miyuki, et al. "Increasing Risk of Disturbed Root Development in Permanent Teeth in Childhood Cancer Survivors Undergoing Cancer Treatment at Older Age." Journal of Pediatric Hematology/oncology, vol. 39, no. 3, 2017, pp. e150-e154.
Tanaka M, Kamata T, Yanagisawa R, et al. Increasing Risk of Disturbed Root Development in Permanent Teeth in Childhood Cancer Survivors Undergoing Cancer Treatment at Older Age. J Pediatr Hematol Oncol. 2017;39(3):e150-e154.
Tanaka, M., Kamata, T., Yanagisawa, R., Morita, D., Saito, S., Sakashita, K., Shiohara, M., Kurita, H., Koike, K., & Nakazawa, Y. (2017). Increasing Risk of Disturbed Root Development in Permanent Teeth in Childhood Cancer Survivors Undergoing Cancer Treatment at Older Age. Journal of Pediatric Hematology/oncology, 39(3), e150-e154. https://doi.org/10.1097/MPH.0000000000000788
Tanaka M, et al. Increasing Risk of Disturbed Root Development in Permanent Teeth in Childhood Cancer Survivors Undergoing Cancer Treatment at Older Age. J Pediatr Hematol Oncol. 2017;39(3):e150-e154. PubMed PMID: 28234739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increasing Risk of Disturbed Root Development in Permanent Teeth in Childhood Cancer Survivors Undergoing Cancer Treatment at Older Age. AU - Tanaka,Miyuki, AU - Kamata,Takahiro, AU - Yanagisawa,Ryu, AU - Morita,Daisuke, AU - Saito,Shoji, AU - Sakashita,Kazuo, AU - Shiohara,Masaaki, AU - Kurita,Hiroshi, AU - Koike,Kenichi, AU - Nakazawa,Yozo, PY - 2017/2/25/pubmed PY - 2017/10/6/medline PY - 2017/2/25/entrez SP - e150 EP - e154 JF - Journal of pediatric hematology/oncology JO - J. Pediatr. Hematol. Oncol. VL - 39 IS - 3 N2 - BACKGROUND: Structural anomalies of teeth are observed at high rates in childhood cancer survivors (CCS). Several therapeutic exposures have been shown to be associated with dental developmental disturbances. This study was conducted to analyze the risk factors for dental developmental abnormality (DDA) and investigate the association between age at the time of cancer treatment and DDA in CCS. PATIENTS AND METHODS: Fifty-six CCS were enrolled. Orthopantomography and dental examination were performed in all the patients. We evaluated the prevalence of DDA and analyzed the risk factors for each type of DDA. RESULTS: DDAs were observed in 46.4% of CCS, including hypodontia in 9 (16.1%), abnormal roots in nine (16.1%), enamel defects/hypoplasia in 6 (10.7%), and microdontia in 12 (21.4%) patients. The number of patients with abnormal roots was significantly higher in the group treated with stem cell transplantation or at an age older than 4 years. We observed that the formation period of abnormal teeth coincided with the treatment period in the majority of CCS with DDA. CONCLUSIONS: Particularly regarding the root abnormality, treatment at elder age may be a risk factor for root developmental disturbances. Risk evaluation, appropriate follow-up, and early detection of dental issues are required for all CCS. SN - 1536-3678 UR - https://www.unboundmedicine.com/medline/citation/28234739/Increasing_Risk_of_Disturbed_Root_Development_in_Permanent_Teeth_in_Childhood_Cancer_Survivors_Undergoing_Cancer_Treatment_at_Older_Age_ L2 - http://dx.doi.org/10.1097/MPH.0000000000000788 DB - PRIME DP - Unbound Medicine ER -