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Protective Role of Tetrahydrocurcumin: an Active Polyphenolic Curcuminoid on Cadmium-InducedOxidative Damage in Rats.
Appl Biochem Biotechnol. 2017 Sep; 183(1):51-69.AB

Abstract

In the present work, protective effect of tetrahydrocurcumin (THC) against oxidative damages in cadmium (Cd)-induced toxicity in rats was evaluated. Cd is an important environmental and industrial toxicant that affects almost all the organs, especially liver. Liver is the major organ responsible for the metabolism and the primary target for many toxic chemicals and drugs. Effect of THC, the curcumin-derived polyphenolic compound on Cd-induced oxidative stress and hepatic damage was evaluated using male albino Wistar rats. In Cd-administered rats (5 mg/kg body weight (b.w.), orally for 4 weeks), activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma glutamyl transferase (GGT) were significantly increased in serum with the elevated level of bilirubin. Red blood cells (RBC), haemoglobin contents and haematocrit values were also significantly decreased in Cd-treated rats. In addition, the levels of lipid peroxidation markers like thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LHP), protein carbonyl contents (PCC) and conjugated dienes (CD) were significantly increased followed by the significant decrease in the levels of reduced glutathione (GSH), total sulphydryl groups (TSH), ascorbic acid (vitamin C) and vitamin E in liver of Cd-administered rats. Oral administration of THC (20, 40 and 80 mg/kg b.w.) followed by Cd for 4 weeks showed a significant restoration of the above changes to near normal. Histopathological changes observed in Cd intoxicated hepatic tissues were minimized on treatment with THC. This study suggests that THC at the dose of 80 mg/kg b.w. effectively subdues the Cd-induced toxicity and controls the free radical-induced liver damage in rats.

Authors+Show Affiliations

Department of Biochemistry, St. Joseph's College of Arts & Science (Autonomous), Cuddalore, 607001, Tamil Nadu, India. vivekaramakrishnan@yahoo.co.in.Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tami Nadu, 608002, India.Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tami Nadu, 608002, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28236190

Citation

Ramakrishnan, Ramalingam, et al. "Protective Role of Tetrahydrocurcumin: an Active Polyphenolic Curcuminoid On Cadmium-InducedOxidative Damage in Rats." Applied Biochemistry and Biotechnology, vol. 183, no. 1, 2017, pp. 51-69.
Ramakrishnan R, Elangovan P, Pari L. Protective Role of Tetrahydrocurcumin: an Active Polyphenolic Curcuminoid on Cadmium-InducedOxidative Damage in Rats. Appl Biochem Biotechnol. 2017;183(1):51-69.
Ramakrishnan, R., Elangovan, P., & Pari, L. (2017). Protective Role of Tetrahydrocurcumin: an Active Polyphenolic Curcuminoid on Cadmium-InducedOxidative Damage in Rats. Applied Biochemistry and Biotechnology, 183(1), 51-69. https://doi.org/10.1007/s12010-017-2430-7
Ramakrishnan R, Elangovan P, Pari L. Protective Role of Tetrahydrocurcumin: an Active Polyphenolic Curcuminoid On Cadmium-InducedOxidative Damage in Rats. Appl Biochem Biotechnol. 2017;183(1):51-69. PubMed PMID: 28236190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective Role of Tetrahydrocurcumin: an Active Polyphenolic Curcuminoid on Cadmium-InducedOxidative Damage in Rats. AU - Ramakrishnan,Ramalingam, AU - Elangovan,Perumal, AU - Pari,Leelavinothan, Y1 - 2017/02/24/ PY - 2016/11/14/received PY - 2017/01/25/accepted PY - 2017/2/27/pubmed PY - 2018/1/3/medline PY - 2017/2/26/entrez KW - Antioxidants KW - Cadmium toxicity KW - Oxidative stress KW - Polyphenolic compound KW - Tetrahydrocurcumin SP - 51 EP - 69 JF - Applied biochemistry and biotechnology JO - Appl Biochem Biotechnol VL - 183 IS - 1 N2 - In the present work, protective effect of tetrahydrocurcumin (THC) against oxidative damages in cadmium (Cd)-induced toxicity in rats was evaluated. Cd is an important environmental and industrial toxicant that affects almost all the organs, especially liver. Liver is the major organ responsible for the metabolism and the primary target for many toxic chemicals and drugs. Effect of THC, the curcumin-derived polyphenolic compound on Cd-induced oxidative stress and hepatic damage was evaluated using male albino Wistar rats. In Cd-administered rats (5 mg/kg body weight (b.w.), orally for 4 weeks), activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and gamma glutamyl transferase (GGT) were significantly increased in serum with the elevated level of bilirubin. Red blood cells (RBC), haemoglobin contents and haematocrit values were also significantly decreased in Cd-treated rats. In addition, the levels of lipid peroxidation markers like thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LHP), protein carbonyl contents (PCC) and conjugated dienes (CD) were significantly increased followed by the significant decrease in the levels of reduced glutathione (GSH), total sulphydryl groups (TSH), ascorbic acid (vitamin C) and vitamin E in liver of Cd-administered rats. Oral administration of THC (20, 40 and 80 mg/kg b.w.) followed by Cd for 4 weeks showed a significant restoration of the above changes to near normal. Histopathological changes observed in Cd intoxicated hepatic tissues were minimized on treatment with THC. This study suggests that THC at the dose of 80 mg/kg b.w. effectively subdues the Cd-induced toxicity and controls the free radical-induced liver damage in rats. SN - 1559-0291 UR - https://www.unboundmedicine.com/medline/citation/28236190/Protective_Role_of_Tetrahydrocurcumin:_an_Active_Polyphenolic_Curcuminoid_on_Cadmium_InducedOxidative_Damage_in_Rats_ L2 - https://dx.doi.org/10.1007/s12010-017-2430-7 DB - PRIME DP - Unbound Medicine ER -