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Carbohydrate quality and quantity affects the composition of the red blood cell fatty acid membrane in overweight and obese individuals.
Clin Nutr 2018; 37(2):481-487CN

Abstract

BACKGROUND

Cell membrane fatty acid (FA) composition may play a role in human metabolic diseases. However, the modulatory effect of nutrients other than fat is poorly explored.

OBJECTIVE

To investigate the effect of moderate-carbohydrate diets with different glycemic indices (GI) and a low-fat diet (LF) on red blood cell (RBC) FA membrane composition.

DESIGN

The RBC FA profile was measured in 87 subjects from the GLYNDIET study. Participants were randomly assigned to one of the following energy-restricted diet for 6 months: moderate-carbohydrate/low-GI diet (LGI, n = 31), moderate-carbohydrate/high-GI diet (HGI, n = 30) or LF-diet (n = 26).

RESULTS

We observed a significant increase in C20:0 and decrease in C20:3n-6 in the LGI and HGI groups compared to LF group. Compared to LF-diet, C22:4n-6 was lower after the HGI while C22:6n-3 was higher after LGI diet. Also, a tendency was found for higher concentrations of long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) in LGI compared to HGI and LF groups. The intra-group analysis showed significantly increased levels of total monounsaturated fatty acids (MUFA) after LGI and HGI interventions, as well as a significant increase in C22:5n-6 and a decrease in LCn-3PUFA and omega-3-index after the LF diet. The decrease in C20:5n-3 after HGI and LF diets was also significant.

CONCLUSION

Diets with a moderate amount of carbohydrates and healthy fat, mainly with LGI, modify the RBC fatty acid membrane composition.

Authors+Show Affiliations

Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institute of Health Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.Lipid Clinic, Endocrinology and Nutrition Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institute of Health Pere Virgili, Universitat Rovira i Virgili, Reus, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.Lipid Clinic, Endocrinology and Nutrition Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institute of Health Pere Virgili, Universitat Rovira i Virgili, Reus, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.Human Nutrition Unit, Faculty of Medicine and Health Sciences, Institute of Health Pere Virgili, Universitat Rovira i Virgili, Reus, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Electronic address: monica.bullo@urv.cat.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28237295

Citation

Giardina, Simona, et al. "Carbohydrate Quality and Quantity Affects the Composition of the Red Blood Cell Fatty Acid Membrane in Overweight and Obese Individuals." Clinical Nutrition (Edinburgh, Scotland), vol. 37, no. 2, 2018, pp. 481-487.
Giardina S, Sala-Vila A, Hernández-Alonso P, et al. Carbohydrate quality and quantity affects the composition of the red blood cell fatty acid membrane in overweight and obese individuals. Clin Nutr. 2018;37(2):481-487.
Giardina, S., Sala-Vila, A., Hernández-Alonso, P., Calvo, C., Salas-Salvadó, J., & Bulló, M. (2018). Carbohydrate quality and quantity affects the composition of the red blood cell fatty acid membrane in overweight and obese individuals. Clinical Nutrition (Edinburgh, Scotland), 37(2), pp. 481-487. doi:10.1016/j.clnu.2017.02.006.
Giardina S, et al. Carbohydrate Quality and Quantity Affects the Composition of the Red Blood Cell Fatty Acid Membrane in Overweight and Obese Individuals. Clin Nutr. 2018;37(2):481-487. PubMed PMID: 28237295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbohydrate quality and quantity affects the composition of the red blood cell fatty acid membrane in overweight and obese individuals. AU - Giardina,Simona, AU - Sala-Vila,Aleix, AU - Hernández-Alonso,Pablo, AU - Calvo,Carlos, AU - Salas-Salvadó,Jordi, AU - Bulló,Mònica, Y1 - 2017/02/11/ PY - 2016/08/31/received PY - 2017/02/01/revised PY - 2017/02/02/accepted PY - 2017/2/27/pubmed PY - 2019/8/31/medline PY - 2017/2/27/entrez KW - Cell membrane KW - DHA KW - Dietary intervention KW - EPA KW - Fatty acids KW - Glycemic index SP - 481 EP - 487 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 37 IS - 2 N2 - BACKGROUND: Cell membrane fatty acid (FA) composition may play a role in human metabolic diseases. However, the modulatory effect of nutrients other than fat is poorly explored. OBJECTIVE: To investigate the effect of moderate-carbohydrate diets with different glycemic indices (GI) and a low-fat diet (LF) on red blood cell (RBC) FA membrane composition. DESIGN: The RBC FA profile was measured in 87 subjects from the GLYNDIET study. Participants were randomly assigned to one of the following energy-restricted diet for 6 months: moderate-carbohydrate/low-GI diet (LGI, n = 31), moderate-carbohydrate/high-GI diet (HGI, n = 30) or LF-diet (n = 26). RESULTS: We observed a significant increase in C20:0 and decrease in C20:3n-6 in the LGI and HGI groups compared to LF group. Compared to LF-diet, C22:4n-6 was lower after the HGI while C22:6n-3 was higher after LGI diet. Also, a tendency was found for higher concentrations of long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) in LGI compared to HGI and LF groups. The intra-group analysis showed significantly increased levels of total monounsaturated fatty acids (MUFA) after LGI and HGI interventions, as well as a significant increase in C22:5n-6 and a decrease in LCn-3PUFA and omega-3-index after the LF diet. The decrease in C20:5n-3 after HGI and LF diets was also significant. CONCLUSION: Diets with a moderate amount of carbohydrates and healthy fat, mainly with LGI, modify the RBC fatty acid membrane composition. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/28237295/Carbohydrate_quality_and_quantity_affects_the_composition_of_the_red_blood_cell_fatty_acid_membrane_in_overweight_and_obese_individuals_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(17)30056-0 DB - PRIME DP - Unbound Medicine ER -