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Mechanical ventilation in acute respiratory distress syndrome: The open lung revisited.
Med Intensiva. 2017 Dec; 41(9):550-558.MI

Abstract

Acute respiratory distress syndrome (ARDS) is still related to high mortality and morbidity rates. Most patients with ARDS will require ventilatory support. This treatment has a direct impact upon patient outcome and is associated to major side effects. In this regard, ventilator-associated lung injury (VALI) is the main concern when this technique is used. The ultimate mechanisms of VALI and its management are under constant evolution. The present review describes the classical mechanisms of VALI and how they have evolved with recent findings from physiopathological and clinical studies, with the aim of analyzing the clinical implications derived from them. Lastly, a series of knowledge-based recommendations are proposed that can be helpful for the ventilator assisted management of ARDS at the patient bedside.

Authors+Show Affiliations

Unidad de Gestión Clínica de Medicina Intensiva, Hospital Valle del Nalón, Langreo, Spain.Unidad de Cuidados Intensivos Cardiológicos, Hospital Universitario Central de Asturias, Oviedo, Spain.Servicio de Medicina Intensiva, Hospital Universitario Central de Asturias, Oviedo, Spain.Unidad de Cuidados Intensivos Cardiológicos, Hospital Universitario Central de Asturias, Oviedo, Spain; Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain. Electronic address: Guillermo.muniz@sespa.es.

Pub Type(s)

Journal Article
Review

Language

eng spa

PubMed ID

28238441

Citation

Amado-Rodríguez, L, et al. "Mechanical Ventilation in Acute Respiratory Distress Syndrome: the Open Lung Revisited." Medicina Intensiva, vol. 41, no. 9, 2017, pp. 550-558.
Amado-Rodríguez L, Del Busto C, García-Prieto E, et al. Mechanical ventilation in acute respiratory distress syndrome: The open lung revisited. Med Intensiva. 2017;41(9):550-558.
Amado-Rodríguez, L., Del Busto, C., García-Prieto, E., & Albaiceta, G. M. (2017). Mechanical ventilation in acute respiratory distress syndrome: The open lung revisited. Medicina Intensiva, 41(9), 550-558. https://doi.org/10.1016/j.medin.2016.12.012
Amado-Rodríguez L, et al. Mechanical Ventilation in Acute Respiratory Distress Syndrome: the Open Lung Revisited. Med Intensiva. 2017;41(9):550-558. PubMed PMID: 28238441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanical ventilation in acute respiratory distress syndrome: The open lung revisited. AU - Amado-Rodríguez,L, AU - Del Busto,C, AU - García-Prieto,E, AU - Albaiceta,G M, Y1 - 2017/02/24/ PY - 2016/12/19/received PY - 2016/12/26/accepted PY - 2017/2/28/pubmed PY - 2018/8/14/medline PY - 2017/2/28/entrez KW - Acute respiratory distress syndrome KW - Lesión pulmonar asociada a ventilador KW - Mechanical ventilation KW - Síndrome de dificultad respiratoria aguda KW - Ventilación mecánica KW - Ventilator-associated lung injury SP - 550 EP - 558 JF - Medicina intensiva JO - Med Intensiva VL - 41 IS - 9 N2 - Acute respiratory distress syndrome (ARDS) is still related to high mortality and morbidity rates. Most patients with ARDS will require ventilatory support. This treatment has a direct impact upon patient outcome and is associated to major side effects. In this regard, ventilator-associated lung injury (VALI) is the main concern when this technique is used. The ultimate mechanisms of VALI and its management are under constant evolution. The present review describes the classical mechanisms of VALI and how they have evolved with recent findings from physiopathological and clinical studies, with the aim of analyzing the clinical implications derived from them. Lastly, a series of knowledge-based recommendations are proposed that can be helpful for the ventilator assisted management of ARDS at the patient bedside. SN - 1578-6749 UR - https://www.unboundmedicine.com/medline/citation/28238441/Mechanical_ventilation_in_acute_respiratory_distress_syndrome:_The_open_lung_revisited_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0210-5691(17)30028-1 DB - PRIME DP - Unbound Medicine ER -