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Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice.
Brain Res. 1987 Sep 08; 420(1):100-8.BR

Abstract

The possibility that the opioid delta-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective mu- and delta-agonist and -antagonists. Antinociceptive dose-response curves were constructed for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO; morphine) and delta ([D-Pen2,D-Pen5]enkephalin, DPDPE)-agonists in the absence, and in the presence of the mu non-surmountable antagonist, beta-funaltrexamine (beta-FNA) or the delta-antagonist ICI 174,864 (N,N-diallyl-Tyr-Aib-Aib-Phe-Leu-OH, where Aib is alpha-amino-isobutyric acid). Agonists and ICI 174,864 were given alone in the same intracerebroventricular (i.c.v.) or intrathecal (i.th.) injection to mice 20 min prior to testing in the warm-water (55 degrees C) tail-withdrawal test (+10 min for i.th. DPDPE); beta-FNA was given as a single i.c.v. or i.th. pretreatment dose (20 and 0.01 nM, respectively) 4 h prior to testing. I.c.v. pretreatment with beta-FNA resulted in a rightward displacement of the DAGO and morphine antinociceptive dose-response lines, but failed to displace the i.c.v. DPDPE curve. Similarly, i.th. pretreatment with beta-FNA displaced the i.th. morphine dose-response curve to the right without affecting the i.th. DPDPE antinociceptive dose-response line. ICI 174,864 (1 and 3 micrograms) produced a dose-related antagonism of i.c.v. or i.th. DPDPE, but did not alter the antinociceptive effects of DAGO or morphine given by the same routes. Co-administration of ICI 174,864 (3 micrograms) with i.c.v. morphine in beta-FNA pretreated (but not control) mice resulted in a further rightward displacement of the morphine dose-response line.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Pharmacology, University of Arizona Health Sciences Center, Tucson 85724.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2823970

Citation

Heyman, J S., et al. "Opioid Delta-receptor Involvement in Supraspinal and Spinal Antinociception in Mice." Brain Research, vol. 420, no. 1, 1987, pp. 100-8.
Heyman JS, Mulvaney SA, Mosberg HI, et al. Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice. Brain Res. 1987;420(1):100-8.
Heyman, J. S., Mulvaney, S. A., Mosberg, H. I., & Porreca, F. (1987). Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice. Brain Research, 420(1), 100-8.
Heyman JS, et al. Opioid Delta-receptor Involvement in Supraspinal and Spinal Antinociception in Mice. Brain Res. 1987 Sep 8;420(1):100-8. PubMed PMID: 2823970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice. AU - Heyman,J S, AU - Mulvaney,S A, AU - Mosberg,H I, AU - Porreca,F, PY - 1987/9/8/pubmed PY - 1987/9/8/medline PY - 1987/9/8/entrez SP - 100 EP - 8 JF - Brain research JO - Brain Res VL - 420 IS - 1 N2 - The possibility that the opioid delta-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective mu- and delta-agonist and -antagonists. Antinociceptive dose-response curves were constructed for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO; morphine) and delta ([D-Pen2,D-Pen5]enkephalin, DPDPE)-agonists in the absence, and in the presence of the mu non-surmountable antagonist, beta-funaltrexamine (beta-FNA) or the delta-antagonist ICI 174,864 (N,N-diallyl-Tyr-Aib-Aib-Phe-Leu-OH, where Aib is alpha-amino-isobutyric acid). Agonists and ICI 174,864 were given alone in the same intracerebroventricular (i.c.v.) or intrathecal (i.th.) injection to mice 20 min prior to testing in the warm-water (55 degrees C) tail-withdrawal test (+10 min for i.th. DPDPE); beta-FNA was given as a single i.c.v. or i.th. pretreatment dose (20 and 0.01 nM, respectively) 4 h prior to testing. I.c.v. pretreatment with beta-FNA resulted in a rightward displacement of the DAGO and morphine antinociceptive dose-response lines, but failed to displace the i.c.v. DPDPE curve. Similarly, i.th. pretreatment with beta-FNA displaced the i.th. morphine dose-response curve to the right without affecting the i.th. DPDPE antinociceptive dose-response line. ICI 174,864 (1 and 3 micrograms) produced a dose-related antagonism of i.c.v. or i.th. DPDPE, but did not alter the antinociceptive effects of DAGO or morphine given by the same routes. Co-administration of ICI 174,864 (3 micrograms) with i.c.v. morphine in beta-FNA pretreated (but not control) mice resulted in a further rightward displacement of the morphine dose-response line.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/2823970/Opioid_delta_receptor_involvement_in_supraspinal_and_spinal_antinociception_in_mice_ DB - PRIME DP - Unbound Medicine ER -