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Standardized serum 25-hydroxyvitamin D concentrations are inversely associated with cardiometabolic disease in U.S. adults: a cross-sectional analysis of NHANES, 2001-2010.
Nutr J. 2017 02 28; 16(1):16.NJ

Abstract

BACKGROUND

Previously reported associations between vitamin D status, as measured by serum 25-hydroxyvitamin D [25(OH)D] concentrations, and cardiometabolic risk factors were largely limited by variability in 25(OH)D assay performance. In accordance with the Vitamin D Standardization Program, serum 25(OH)D measurement was recently standardized in the National Health and Nutrition Examination Survey (NHANES) to reduce laboratory and method related differences in serum 25(OH)D results. We evaluated the overall and ethnic-specific associations between the newly standardized serum 25(OH)D concentrations and cardiometabolic risk in U.S. adults.

METHODS

This study examined standardized 25(OH)D data from five cycles of the NHANES (2001-2010). The total sample included 7674 participants (1794 Mexican-Americans, 4289 non-Hispanic whites, and 1591 non-Hispanic blacks) aged ≥ 20 years who were examined in the morning after overnight fasting. Serum 25(OH)D was directly measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in 2007-2010, and was predicted from LC-MS/MS equivalents for 2001-2006. Serum 25(OH)D levels were categorized into quartiles (<43.4, 43.4-58.6, 58.7-74.2, ≥74.3 nmol/L). Cardiometabolic risk was defined by the homeostatic model assessment of insulin resistance (HOMA-IR), metabolic syndrome (MetS), and Framingham cardiovascular disease (CVD) risk. Prevalence ratios and 95% confidence intervals were calculated using modified Poisson regression.

RESULTS

After full adjustment for confounders, serum 25(OH)D ≥74.3 nmol/L was associated with lower cardiometabolic risk compared to 25(OH)D <43.4 nmol/L in the overall sample [HOMA-IR: 0.70 (0.59, 0.84); MetS: 0.82 (0.74, 0.91); CVD risk: 0.78 (0.66, 0.91)]. These associations remained significant in Mexican-Americans [HOMA-IR: 0.54 (0.35, 0.82); MetS: 0.73 (0.55, 0.96)], non-Hispanic whites [HOMA-IR: 0.81 (0.68, 0.96); MetS: 0.84 (0.73, 0.95); CVD risk: 0.78 (0.64, 0.93)]; and in non-Hispanic blacks [HOMA-IR: 0.67 (0.45, 0.99); MetS: 0.75 (0.56, 0.97); CVD risk: 0.58 (0.41, 0.81)].

CONCLUSIONS

Low vitamin D status is a significant risk factor for cardiometabolic disease in U.S. adults based on standardized serum 25(OH)D results, irrespective of ethnic background. Future studies using standardized 25(OH)D data are needed to confirm these results, particularly amongst U.S. blacks with 25(OH)D concentrations above 75 nmol/L.

Authors+Show Affiliations

School of Kinesiology and Health Science, York University, Toronto, M3J1P3, ON, Canada. khalidib@yorku.ca.Pure North S'Energy Foundation, Calgary, AB, Canada.School of Kinesiology and Health Science, York University, Toronto, M3J1P3, ON, Canada.School of Kinesiology and Health Science, York University, Toronto, M3J1P3, ON, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28241878

Citation

Al-Khalidi, Banaz, et al. "Standardized Serum 25-hydroxyvitamin D Concentrations Are Inversely Associated With Cardiometabolic Disease in U.S. Adults: a Cross-sectional Analysis of NHANES, 2001-2010." Nutrition Journal, vol. 16, no. 1, 2017, p. 16.
Al-Khalidi B, Kimball SM, Rotondi MA, et al. Standardized serum 25-hydroxyvitamin D concentrations are inversely associated with cardiometabolic disease in U.S. adults: a cross-sectional analysis of NHANES, 2001-2010. Nutr J. 2017;16(1):16.
Al-Khalidi, B., Kimball, S. M., Rotondi, M. A., & Ardern, C. I. (2017). Standardized serum 25-hydroxyvitamin D concentrations are inversely associated with cardiometabolic disease in U.S. adults: a cross-sectional analysis of NHANES, 2001-2010. Nutrition Journal, 16(1), 16. https://doi.org/10.1186/s12937-017-0237-6
Al-Khalidi B, et al. Standardized Serum 25-hydroxyvitamin D Concentrations Are Inversely Associated With Cardiometabolic Disease in U.S. Adults: a Cross-sectional Analysis of NHANES, 2001-2010. Nutr J. 2017 02 28;16(1):16. PubMed PMID: 28241878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Standardized serum 25-hydroxyvitamin D concentrations are inversely associated with cardiometabolic disease in U.S. adults: a cross-sectional analysis of NHANES, 2001-2010. AU - Al-Khalidi,Banaz, AU - Kimball,Samantha M, AU - Rotondi,Michael A, AU - Ardern,Chris I, Y1 - 2017/02/28/ PY - 2016/10/06/received PY - 2017/02/22/accepted PY - 2017/3/1/entrez PY - 2017/3/1/pubmed PY - 2017/10/19/medline KW - Ethnicity KW - Framingham CVD risk KW - Insulin resistance KW - Metabolic syndrome population survey KW - Standardized 25-Hydroxyvitamin D KW - Vitamin D SP - 16 EP - 16 JF - Nutrition journal JO - Nutr J VL - 16 IS - 1 N2 - BACKGROUND: Previously reported associations between vitamin D status, as measured by serum 25-hydroxyvitamin D [25(OH)D] concentrations, and cardiometabolic risk factors were largely limited by variability in 25(OH)D assay performance. In accordance with the Vitamin D Standardization Program, serum 25(OH)D measurement was recently standardized in the National Health and Nutrition Examination Survey (NHANES) to reduce laboratory and method related differences in serum 25(OH)D results. We evaluated the overall and ethnic-specific associations between the newly standardized serum 25(OH)D concentrations and cardiometabolic risk in U.S. adults. METHODS: This study examined standardized 25(OH)D data from five cycles of the NHANES (2001-2010). The total sample included 7674 participants (1794 Mexican-Americans, 4289 non-Hispanic whites, and 1591 non-Hispanic blacks) aged ≥ 20 years who were examined in the morning after overnight fasting. Serum 25(OH)D was directly measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in 2007-2010, and was predicted from LC-MS/MS equivalents for 2001-2006. Serum 25(OH)D levels were categorized into quartiles (<43.4, 43.4-58.6, 58.7-74.2, ≥74.3 nmol/L). Cardiometabolic risk was defined by the homeostatic model assessment of insulin resistance (HOMA-IR), metabolic syndrome (MetS), and Framingham cardiovascular disease (CVD) risk. Prevalence ratios and 95% confidence intervals were calculated using modified Poisson regression. RESULTS: After full adjustment for confounders, serum 25(OH)D ≥74.3 nmol/L was associated with lower cardiometabolic risk compared to 25(OH)D <43.4 nmol/L in the overall sample [HOMA-IR: 0.70 (0.59, 0.84); MetS: 0.82 (0.74, 0.91); CVD risk: 0.78 (0.66, 0.91)]. These associations remained significant in Mexican-Americans [HOMA-IR: 0.54 (0.35, 0.82); MetS: 0.73 (0.55, 0.96)], non-Hispanic whites [HOMA-IR: 0.81 (0.68, 0.96); MetS: 0.84 (0.73, 0.95); CVD risk: 0.78 (0.64, 0.93)]; and in non-Hispanic blacks [HOMA-IR: 0.67 (0.45, 0.99); MetS: 0.75 (0.56, 0.97); CVD risk: 0.58 (0.41, 0.81)]. CONCLUSIONS: Low vitamin D status is a significant risk factor for cardiometabolic disease in U.S. adults based on standardized serum 25(OH)D results, irrespective of ethnic background. Future studies using standardized 25(OH)D data are needed to confirm these results, particularly amongst U.S. blacks with 25(OH)D concentrations above 75 nmol/L. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/28241878/Standardized_serum_25_hydroxyvitamin_D_concentrations_are_inversely_associated_with_cardiometabolic_disease_in_U_S__adults:_a_cross_sectional_analysis_of_NHANES_2001_2010_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/s12937-017-0237-6 DB - PRIME DP - Unbound Medicine ER -