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Gadolinium alginate nanogels for theranostic applications.
Colloids Surf B Biointerfaces. 2017 May 01; 153:183-189.CS

Abstract

Synthesis of theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one platform can be considered as a step forward personalized medicine, since it allows tracing the delivery of the drug to targeted organ. Thus, the aim of this work was to prepare gadolinium alginate gel nanoparticles (gadolinum nanogels - GdNG) by the reverse microemulsions and physical crosslinking method as the vehicles able to carry hydrophilic drugs and to be traced by the Magnetic Resonance Imaging (MRI). The average size of synthesized nanoparticles was about 110nm and the batch concentration was 1010 particles/ml. The morphology of nanogeles was visualized by Cryo-Scanning Electron Microscopy. Surface of nanogels particles was modified by the Layer-by-Layer (LbL) technique using natural polyelectrolytes. The cytotoxicity of non-modified and LbL modified nanogels was evaluated by the cellular viability quantification and cell death assessments using MTT and LDH biochemical tests, respectively. We encapsulated the model compound - fluorescent dye (Rhodamine b) in nanogels networks and proved the possibility of GdNG visualization by MRI.

Authors+Show Affiliations

Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, PL-30239, Krakow, Poland. Electronic address: ncpodgor@cyf-kr.edu.pl.Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, PL-30239, Krakow, Poland.Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, PL-30239, Krakow, Poland.University of Chemistry and Technology, Technická 3, 166 28, Prague, Czechia.University of Chemistry and Technology, Technická 3, 166 28, Prague, Czechia.Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, PL-30239, Krakow, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28242371

Citation

Podgórna, K, et al. "Gadolinium Alginate Nanogels for Theranostic Applications." Colloids and Surfaces. B, Biointerfaces, vol. 153, 2017, pp. 183-189.
Podgórna K, Szczepanowicz K, Piotrowski M, et al. Gadolinium alginate nanogels for theranostic applications. Colloids Surf B Biointerfaces. 2017;153:183-189.
Podgórna, K., Szczepanowicz, K., Piotrowski, M., Gajdošová, M., Štěpánek, F., & Warszyński, P. (2017). Gadolinium alginate nanogels for theranostic applications. Colloids and Surfaces. B, Biointerfaces, 153, 183-189. https://doi.org/10.1016/j.colsurfb.2017.02.026
Podgórna K, et al. Gadolinium Alginate Nanogels for Theranostic Applications. Colloids Surf B Biointerfaces. 2017 May 1;153:183-189. PubMed PMID: 28242371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gadolinium alginate nanogels for theranostic applications. AU - Podgórna,K, AU - Szczepanowicz,K, AU - Piotrowski,M, AU - Gajdošová,M, AU - Štěpánek,F, AU - Warszyński,P, Y1 - 2017/02/21/ PY - 2016/10/18/received PY - 2017/02/16/revised PY - 2017/02/18/accepted PY - 2017/3/1/pubmed PY - 2017/4/18/medline PY - 2017/3/1/entrez KW - Alginate KW - Gadolinium KW - LbL KW - Nanogels KW - Polysaccharides KW - Theranostic SP - 183 EP - 189 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 153 N2 - Synthesis of theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one platform can be considered as a step forward personalized medicine, since it allows tracing the delivery of the drug to targeted organ. Thus, the aim of this work was to prepare gadolinium alginate gel nanoparticles (gadolinum nanogels - GdNG) by the reverse microemulsions and physical crosslinking method as the vehicles able to carry hydrophilic drugs and to be traced by the Magnetic Resonance Imaging (MRI). The average size of synthesized nanoparticles was about 110nm and the batch concentration was 1010 particles/ml. The morphology of nanogeles was visualized by Cryo-Scanning Electron Microscopy. Surface of nanogels particles was modified by the Layer-by-Layer (LbL) technique using natural polyelectrolytes. The cytotoxicity of non-modified and LbL modified nanogels was evaluated by the cellular viability quantification and cell death assessments using MTT and LDH biochemical tests, respectively. We encapsulated the model compound - fluorescent dye (Rhodamine b) in nanogels networks and proved the possibility of GdNG visualization by MRI. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/28242371/Gadolinium_alginate_nanogels_for_theranostic_applications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(17)30098-X DB - PRIME DP - Unbound Medicine ER -