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Zika virus: An emerging flavivirus.

Abstract

Zika virus (ZIKV) is a previously little-known flavivirus closely related to Japanese encephalitis, West Nile, dengue, and yellow fever viruses, all of which are primarily transmitted by blood-sucking mosquitoes. Since its discovery in Uganda in 1947, ZIKV has continued to expand its geographic range, from equatorial Africa and Asia to the Pacific Islands, then further afield to South and Central America and the Caribbean. Currently, ZIKV is actively circulating not only in much of Latin America and its neighbors but also in parts of the Pacific Islands and Southeast Asia. Although ZIKV infection generally causes only mild symptoms in some infected individuals, it is associated with a range of neuroimmunological disorders, including Guillain-Barré syndrome, meningoencephalitis, and myelitis. Recently, maternal ZIKV infection during pregnancy has been linked to neonatal malformations, resulting in various degrees of congenital abnormalities, microcephaly, and even abortion. Despite its emergence as an important public health problem, however, little is known about ZIKV biology, and neither vaccine nor drug is available to control ZIKV infection. This article provides a brief introduction to ZIKV with a major emphasis on its molecular virology, in order to help facilitate the development of diagnostics, therapeutics, and vaccines.

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  • Authors+Show Affiliations

    ,

    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA.

    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, UT, 84322-4815, USA. youngmin.lee@usu.edu. Utah Science Technology and Research, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, 84322-4815, USA. youngmin.lee@usu.edu.

    Source

    MeSH

    Animals
    Communicable Diseases, Emerging
    Congenital Abnormalities
    Disease Outbreaks
    Female
    Genotype
    Humans
    Pregnancy
    Pregnancy Complications, Infectious
    Public Health
    RNA, Viral
    Virus Replication
    Zika Virus
    Zika Virus Infection

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    28243937

    Citation

    Yun, Sang-Im, and Young-Min Lee. "Zika Virus: an Emerging Flavivirus." Journal of Microbiology (Seoul, Korea), vol. 55, no. 3, 2017, pp. 204-219.
    Yun SI, Lee YM. Zika virus: An emerging flavivirus. J Microbiol. 2017;55(3):204-219.
    Yun, S. I., & Lee, Y. M. (2017). Zika virus: An emerging flavivirus. Journal of Microbiology (Seoul, Korea), 55(3), pp. 204-219. doi:10.1007/s12275-017-7063-6.
    Yun SI, Lee YM. Zika Virus: an Emerging Flavivirus. J Microbiol. 2017;55(3):204-219. PubMed PMID: 28243937.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Zika virus: An emerging flavivirus. AU - Yun,Sang-Im, AU - Lee,Young-Min, Y1 - 2017/02/28/ PY - 2017/02/10/received PY - 2017/02/15/accepted PY - 2017/3/1/entrez PY - 2017/3/1/pubmed PY - 2017/3/18/medline KW - Guillain-Barré syndrome KW - Zika virus KW - arbovirus KW - flavivirus KW - microcephaly KW - mosquito-borne virus KW - pathogenesis KW - replication SP - 204 EP - 219 JF - Journal of microbiology (Seoul, Korea) JO - J. Microbiol. VL - 55 IS - 3 N2 - Zika virus (ZIKV) is a previously little-known flavivirus closely related to Japanese encephalitis, West Nile, dengue, and yellow fever viruses, all of which are primarily transmitted by blood-sucking mosquitoes. Since its discovery in Uganda in 1947, ZIKV has continued to expand its geographic range, from equatorial Africa and Asia to the Pacific Islands, then further afield to South and Central America and the Caribbean. Currently, ZIKV is actively circulating not only in much of Latin America and its neighbors but also in parts of the Pacific Islands and Southeast Asia. Although ZIKV infection generally causes only mild symptoms in some infected individuals, it is associated with a range of neuroimmunological disorders, including Guillain-Barré syndrome, meningoencephalitis, and myelitis. Recently, maternal ZIKV infection during pregnancy has been linked to neonatal malformations, resulting in various degrees of congenital abnormalities, microcephaly, and even abortion. Despite its emergence as an important public health problem, however, little is known about ZIKV biology, and neither vaccine nor drug is available to control ZIKV infection. This article provides a brief introduction to ZIKV with a major emphasis on its molecular virology, in order to help facilitate the development of diagnostics, therapeutics, and vaccines. SN - 1976-3794 UR - https://www.unboundmedicine.com/medline/citation/28243937/Zika_virus:_An_emerging_flavivirus_ L2 - https://dx.doi.org/10.1007/s12275-017-7063-6 DB - PRIME DP - Unbound Medicine ER -