Tags

Type your tag names separated by a space and hit enter

Increased Serum Antibody Titer against HPV-16 Antigen in Patients with Behçet's Disease.
J Korean Med Sci. 2017 Apr; 32(4):599-604.JK

Abstract

Quadrivalent human papillomavirus (HPV) vaccine has been reported to be significantly associated with Behçet's disease (BD). However, no reports have described HPV infection as a possible cause for the development of BD. The objective of this study was to evaluate whether anti-HPV immunoglobulin G (IgG) antibody titer is increased in BD. Serum samples from 93 Korean BD patients, who fulfilled the diagnostic criteria of the International Study Group for BD, were used in an enzyme-linked immunosorbent assay (ELISA). The clinical activity of BD was evaluated at the time of blood sampling. HPV-16 L1 virus-like particle (VLP) antigen was used in this study for the ELISA. Patients with BD had significantly higher antibody titers against HPV-16 (optical density [OD], 0.210-3.675; mean 0.992) than that of healthy controls (OD, 0.248-0.762; mean 0.517; P < 0.001). Using a receiver operating characteristic (ROC) analysis, a cut-off value of 0.578 OD for the anti-HPV antibody titer was determined that differentiated BD patients from healthy controls. When we compared the clinical features of BD between the 2 groups, articular involvement of BD was more likely in patients with an anti-HPV-16 antibody titer < 0.578 OD (P = 0.035). In addition, patients with an anti-HPV-16 antibody titer < 0.578 were significantly younger than those with a titer ≥ 0.578 OD. HPV itself may be a possible extrinsic triggering infectious agent causing the development of BD.

Authors+Show Affiliations

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. DSKIM6634@yuhs.ac.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28244285

Citation

Kim, Kyu Yeun, et al. "Increased Serum Antibody Titer Against HPV-16 Antigen in Patients With Behçet's Disease." Journal of Korean Medical Science, vol. 32, no. 4, 2017, pp. 599-604.
Kim KY, Kim DY, Seo J, et al. Increased Serum Antibody Titer against HPV-16 Antigen in Patients with Behçet's Disease. J Korean Med Sci. 2017;32(4):599-604.
Kim, K. Y., Kim, D. Y., Seo, J., Ahn, Y., & Kim, D. S. (2017). Increased Serum Antibody Titer against HPV-16 Antigen in Patients with Behçet's Disease. Journal of Korean Medical Science, 32(4), 599-604. https://doi.org/10.3346/jkms.2017.32.4.599
Kim KY, et al. Increased Serum Antibody Titer Against HPV-16 Antigen in Patients With Behçet's Disease. J Korean Med Sci. 2017;32(4):599-604. PubMed PMID: 28244285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased Serum Antibody Titer against HPV-16 Antigen in Patients with Behçet's Disease. AU - Kim,Kyu Yeun, AU - Kim,Do Young, AU - Seo,Jimyung, AU - Ahn,Yuri, AU - Kim,Dong Soo, PY - 2016/08/30/received PY - 2016/12/28/accepted PY - 2017/3/1/entrez PY - 2017/3/1/pubmed PY - 2017/5/24/medline KW - Behçet's Disease KW - Enzyme-Linked Immunosorbent Assay KW - Human Papilloma Virus KW - IgG Antibody SP - 599 EP - 604 JF - Journal of Korean medical science JO - J. Korean Med. Sci. VL - 32 IS - 4 N2 - Quadrivalent human papillomavirus (HPV) vaccine has been reported to be significantly associated with Behçet's disease (BD). However, no reports have described HPV infection as a possible cause for the development of BD. The objective of this study was to evaluate whether anti-HPV immunoglobulin G (IgG) antibody titer is increased in BD. Serum samples from 93 Korean BD patients, who fulfilled the diagnostic criteria of the International Study Group for BD, were used in an enzyme-linked immunosorbent assay (ELISA). The clinical activity of BD was evaluated at the time of blood sampling. HPV-16 L1 virus-like particle (VLP) antigen was used in this study for the ELISA. Patients with BD had significantly higher antibody titers against HPV-16 (optical density [OD], 0.210-3.675; mean 0.992) than that of healthy controls (OD, 0.248-0.762; mean 0.517; P < 0.001). Using a receiver operating characteristic (ROC) analysis, a cut-off value of 0.578 OD for the anti-HPV antibody titer was determined that differentiated BD patients from healthy controls. When we compared the clinical features of BD between the 2 groups, articular involvement of BD was more likely in patients with an anti-HPV-16 antibody titer < 0.578 OD (P = 0.035). In addition, patients with an anti-HPV-16 antibody titer < 0.578 were significantly younger than those with a titer ≥ 0.578 OD. HPV itself may be a possible extrinsic triggering infectious agent causing the development of BD. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/28244285/Increased_Serum_Antibody_Titer_against_HPV_16_Antigen_in_Patients_with_Behçet's_Disease_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2017.32.4.599 DB - PRIME DP - Unbound Medicine ER -