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Lifestyle for Brain Health (LIBRA): a new model for dementia prevention.
Int J Geriatr Psychiatry. 2018 Jan; 33(1):167-175.IJ

Abstract

OBJECTIVE

Modifiable risk factors for dementia were recently identified and compiled in a systematic review. The 'Lifestyle for Brain Health' (LIBRA) score, reflecting someone's potential for dementia prevention, was studied in a large longitudinal population-based sample with respect to predicting cognitive change over an observation period of up to 16 years.

METHODS

Lifestyle for Brain Health was calculated at baseline for 949 participants aged 50-81 years from the Maastricht Ageing Study. The predictive value of LIBRA for incident dementia and cognitive impairment was examined by using Cox proportional hazard models and by testing its relation with cognitive decline.

RESULTS

Lifestyle for Brain Health predicted future risk of dementia, as well as risk of cognitive impairment. A one-point increase in LIBRA score related to 19% higher risk for dementia and 9% higher risk for cognitive impairment. LIBRA predicted rate of decline in processing speed, but not memory or executive functioning.

CONCLUSIONS

Lifestyle for Brain Health (LIBRA) may help in identifying and monitoring risk status in dementia-prevention programmes, by targeting modifiable, lifestyle-related risk factors. Copyright © 2017 John Wiley & Sons, Ltd.

Authors+Show Affiliations

School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.School of Nursing and Human Sciences, Dublin City University, Dublin, Ireland.General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.Department of General Practice, Maastricht University, Maastricht, The Netherlands.School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28247500

Citation

Schiepers, Olga J G., et al. "Lifestyle for Brain Health (LIBRA): a New Model for Dementia Prevention." International Journal of Geriatric Psychiatry, vol. 33, no. 1, 2018, pp. 167-175.
Schiepers OJG, Köhler S, Deckers K, et al. Lifestyle for Brain Health (LIBRA): a new model for dementia prevention. Int J Geriatr Psychiatry. 2018;33(1):167-175.
Schiepers, O. J. G., Köhler, S., Deckers, K., Irving, K., O'Donnell, C. A., van den Akker, M., Verhey, F. R. J., Vos, S. J. B., de Vugt, M. E., & van Boxtel, M. P. J. (2018). Lifestyle for Brain Health (LIBRA): a new model for dementia prevention. International Journal of Geriatric Psychiatry, 33(1), 167-175. https://doi.org/10.1002/gps.4700
Schiepers OJG, et al. Lifestyle for Brain Health (LIBRA): a New Model for Dementia Prevention. Int J Geriatr Psychiatry. 2018;33(1):167-175. PubMed PMID: 28247500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lifestyle for Brain Health (LIBRA): a new model for dementia prevention. AU - Schiepers,Olga J G, AU - Köhler,Sebastian, AU - Deckers,Kay, AU - Irving,Kate, AU - O'Donnell,Catherine A, AU - van den Akker,Marjan, AU - Verhey,Frans R J, AU - Vos,Stephanie J B, AU - de Vugt,Marjolein E, AU - van Boxtel,Martin P J, Y1 - 2017/02/28/ PY - 2016/08/22/received PY - 2017/02/08/accepted PY - 2017/3/2/pubmed PY - 2018/7/10/medline PY - 2017/3/2/entrez KW - ageing KW - cognitive function KW - dementia KW - lifestyle KW - prevention SP - 167 EP - 175 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 33 IS - 1 N2 - OBJECTIVE: Modifiable risk factors for dementia were recently identified and compiled in a systematic review. The 'Lifestyle for Brain Health' (LIBRA) score, reflecting someone's potential for dementia prevention, was studied in a large longitudinal population-based sample with respect to predicting cognitive change over an observation period of up to 16 years. METHODS: Lifestyle for Brain Health was calculated at baseline for 949 participants aged 50-81 years from the Maastricht Ageing Study. The predictive value of LIBRA for incident dementia and cognitive impairment was examined by using Cox proportional hazard models and by testing its relation with cognitive decline. RESULTS: Lifestyle for Brain Health predicted future risk of dementia, as well as risk of cognitive impairment. A one-point increase in LIBRA score related to 19% higher risk for dementia and 9% higher risk for cognitive impairment. LIBRA predicted rate of decline in processing speed, but not memory or executive functioning. CONCLUSIONS: Lifestyle for Brain Health (LIBRA) may help in identifying and monitoring risk status in dementia-prevention programmes, by targeting modifiable, lifestyle-related risk factors. Copyright © 2017 John Wiley & Sons, Ltd. SN - 1099-1166 UR - https://www.unboundmedicine.com/medline/citation/28247500/Lifestyle_for_Brain_Health__LIBRA_:_a_new_model_for_dementia_prevention_ L2 - https://doi.org/10.1002/gps.4700 DB - PRIME DP - Unbound Medicine ER -