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[Islet cell carcinoma associated with concurrent Zollinger-Ellison syndrome and Cushing's syndrome].
Gan No Rinsho. 1987 Oct; 33(12):1446-52.GN

Abstract

A tissue specimen taken from the pancreatic tumor of a patient suffering from Zollinger-Ellison syndrome associated with a concurrent Cushing's syndrome was investigated both morphologically and immunohistochemically. Histologically, the tumor cells were found to be arranged in a cord or ribbon pattern. An immunohistochemical study revealed that the tumor nodule contained both gastrin and ACTH. Further, double stainings of the same section disclosed that the same tumor nodule possessed both hormones simultaneously, thus confirming the concurrent presence of Zollinger-Ellison syndrome and Cushing's syndrome. An electron micrograph of the tumor cell showed the presence of numerous endocrine-type granules in the cytoplasm. These findings substantiate the concurrent presence of the two characteristic clinical syndromes.

Authors+Show Affiliations

Dept. of Pathology, Hokkaido Children's Hospital & Medical Center.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

2824877

Citation

Yoshida, Y, et al. "[Islet Cell Carcinoma Associated With Concurrent Zollinger-Ellison Syndrome and Cushing's Syndrome]." Gan No Rinsho. Japan Journal of Cancer Clinics, vol. 33, no. 12, 1987, pp. 1446-52.
Yoshida Y, Tsuji S, Mori M, et al. [Islet cell carcinoma associated with concurrent Zollinger-Ellison syndrome and Cushing's syndrome]. Gan No Rinsho. 1987;33(12):1446-52.
Yoshida, Y., Tsuji, S., Mori, M., Satoh, M., Kamijo, K., Yabana, T., Yachi, A., & Imamura, M. (1987). [Islet cell carcinoma associated with concurrent Zollinger-Ellison syndrome and Cushing's syndrome]. Gan No Rinsho. Japan Journal of Cancer Clinics, 33(12), 1446-52.
Yoshida Y, et al. [Islet Cell Carcinoma Associated With Concurrent Zollinger-Ellison Syndrome and Cushing's Syndrome]. Gan No Rinsho. 1987;33(12):1446-52. PubMed PMID: 2824877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Islet cell carcinoma associated with concurrent Zollinger-Ellison syndrome and Cushing's syndrome]. AU - Yoshida,Y, AU - Tsuji,S, AU - Mori,M, AU - Satoh,M, AU - Kamijo,K, AU - Yabana,T, AU - Yachi,A, AU - Imamura,M, PY - 1987/10/1/pubmed PY - 1987/10/1/medline PY - 1987/10/1/entrez SP - 1446 EP - 52 JF - Gan no rinsho. Japan journal of cancer clinics JO - Gan No Rinsho VL - 33 IS - 12 N2 - A tissue specimen taken from the pancreatic tumor of a patient suffering from Zollinger-Ellison syndrome associated with a concurrent Cushing's syndrome was investigated both morphologically and immunohistochemically. Histologically, the tumor cells were found to be arranged in a cord or ribbon pattern. An immunohistochemical study revealed that the tumor nodule contained both gastrin and ACTH. Further, double stainings of the same section disclosed that the same tumor nodule possessed both hormones simultaneously, thus confirming the concurrent presence of Zollinger-Ellison syndrome and Cushing's syndrome. An electron micrograph of the tumor cell showed the presence of numerous endocrine-type granules in the cytoplasm. These findings substantiate the concurrent presence of the two characteristic clinical syndromes. SN - 0021-4949 UR - https://www.unboundmedicine.com/medline/citation/2824877/[Islet_cell_carcinoma_associated_with_concurrent_Zollinger_Ellison_syndrome_and_Cushing's_syndrome]_ L2 - http://www.diseaseinfosearch.org/result/7600 DB - PRIME DP - Unbound Medicine ER -