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Dairy Intake Is Protective against Bone Loss in Older Vitamin D Supplement Users: The Framingham Study.
J Nutr 2017; 147(4):645-652JN

Abstract

Background:

Previous studies showed beneficial effects of specific dairy foods on bone health in middle-aged adults.

Objective:

We examined the association of milk, yogurt, cheese, cream, fluid dairy (milk + yogurt), and milk + yogurt + cheese intakes with bone mineral density (BMD) and 4-y percentage of change in BMD [▵%BMD; femoral neck, trochanter, and lumbar spine (LS)]. We further assessed whether these associations were modified by vitamin D supplement use in this cohort of older adults.

Methods:

Food-frequency questionnaire responses, baseline BMD (hip and spine, n = 862 in 1988-1989), and follow-up BMD (n = 628 in 1992-1993) were measured in the Framingham study, a prospective cohort study of older Caucasian men and women aged 67-93 y. Outcomes included baseline BMD and ▵%BMD. Dairy-food intakes (servings per week) were converted to energy-adjusted residuals, and linear regression was used, adjusting for covariates. These associations were further examined by vitamin D supplement use.

Results:

The mean age of the participants was 75 y. In the full sample, dairy-food items were not associated with BMD (P = 0.11-0.99) or with ▵%BMD (P = 0.29-0.96). Among vitamin D supplement users, but not among nonusers, higher milk, fluid dairy, and milk + yogurt + cheese intakes were associated with higher LS BMD (P = 0.011-0.009). Among vitamin D supplement users, but not among nonusers, higher milk + yogurt + cheese intakes were protective against trochanter BMD loss (P = 0.009).

Conclusions:

In this population of older adults, higher intakes of milk, fluid dairy, and milk + yogurt + cheese were associated with higher LS BMD, and a higher intake of milk + yogurt + cheese was protective against trochanter BMD loss among vitamin D supplement users but not among nonusers. These findings underscore that the benefits of dairy intake on the skeleton may be dependent on vitamin D intake.

Authors+Show Affiliations

Institute for Aging Research, Hebrew SeniorLife, Boston, MA; shivanisahni@hsl.harvard.edu. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and.Institute for Aging Research, Hebrew SeniorLife, Boston, MA. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and.Institute for Aging Research, Hebrew SeniorLife, Boston, MA. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and.Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts, Lowell, MA.Institute for Aging Research, Hebrew SeniorLife, Boston, MA. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; and.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

28250192

Citation

Sahni, Shivani, et al. "Dairy Intake Is Protective Against Bone Loss in Older Vitamin D Supplement Users: the Framingham Study." The Journal of Nutrition, vol. 147, no. 4, 2017, pp. 645-652.
Sahni S, Mangano KM, Kiel DP, et al. Dairy Intake Is Protective against Bone Loss in Older Vitamin D Supplement Users: The Framingham Study. J Nutr. 2017;147(4):645-652.
Sahni, S., Mangano, K. M., Kiel, D. P., Tucker, K. L., & Hannan, M. T. (2017). Dairy Intake Is Protective against Bone Loss in Older Vitamin D Supplement Users: The Framingham Study. The Journal of Nutrition, 147(4), pp. 645-652. doi:10.3945/jn.116.240390.
Sahni S, et al. Dairy Intake Is Protective Against Bone Loss in Older Vitamin D Supplement Users: the Framingham Study. J Nutr. 2017;147(4):645-652. PubMed PMID: 28250192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dairy Intake Is Protective against Bone Loss in Older Vitamin D Supplement Users: The Framingham Study. AU - Sahni,Shivani, AU - Mangano,Kelsey M, AU - Kiel,Douglas P, AU - Tucker,Katherine L, AU - Hannan,Marian T, Y1 - 2017/03/01/ PY - 2016/08/15/received PY - 2016/09/14/revised PY - 2017/02/03/accepted PY - 2017/3/3/pubmed PY - 2017/6/21/medline PY - 2017/3/3/entrez KW - bone loss KW - bone mineral density KW - dairy food KW - milk KW - observational studies KW - older adults KW - osteoporosis KW - vitamin D SP - 645 EP - 652 JF - The Journal of nutrition JO - J. Nutr. VL - 147 IS - 4 N2 - Background: Previous studies showed beneficial effects of specific dairy foods on bone health in middle-aged adults.Objective: We examined the association of milk, yogurt, cheese, cream, fluid dairy (milk + yogurt), and milk + yogurt + cheese intakes with bone mineral density (BMD) and 4-y percentage of change in BMD [▵%BMD; femoral neck, trochanter, and lumbar spine (LS)]. We further assessed whether these associations were modified by vitamin D supplement use in this cohort of older adults.Methods: Food-frequency questionnaire responses, baseline BMD (hip and spine, n = 862 in 1988-1989), and follow-up BMD (n = 628 in 1992-1993) were measured in the Framingham study, a prospective cohort study of older Caucasian men and women aged 67-93 y. Outcomes included baseline BMD and ▵%BMD. Dairy-food intakes (servings per week) were converted to energy-adjusted residuals, and linear regression was used, adjusting for covariates. These associations were further examined by vitamin D supplement use.Results: The mean age of the participants was 75 y. In the full sample, dairy-food items were not associated with BMD (P = 0.11-0.99) or with ▵%BMD (P = 0.29-0.96). Among vitamin D supplement users, but not among nonusers, higher milk, fluid dairy, and milk + yogurt + cheese intakes were associated with higher LS BMD (P = 0.011-0.009). Among vitamin D supplement users, but not among nonusers, higher milk + yogurt + cheese intakes were protective against trochanter BMD loss (P = 0.009).Conclusions: In this population of older adults, higher intakes of milk, fluid dairy, and milk + yogurt + cheese were associated with higher LS BMD, and a higher intake of milk + yogurt + cheese was protective against trochanter BMD loss among vitamin D supplement users but not among nonusers. These findings underscore that the benefits of dairy intake on the skeleton may be dependent on vitamin D intake. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/28250192/Dairy_Intake_Is_Protective_against_Bone_Loss_in_Older_Vitamin_D_Supplement_Users:_The_Framingham_Study_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.116.240390 DB - PRIME DP - Unbound Medicine ER -