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Multimodal Imaging Evidence for a Frontoparietal Modulation of Visual Cortex during the Selective Processing of Conditioned Threat.
J Cogn Neurosci. 2017 Jun; 29(6):953-967.JC

Abstract

Emotionally salient cues are detected more readily, remembered better, and evoke greater visual cortical responses compared with neutral stimuli. The current study used concurrent EEG-fMRI recordings to identify large-scale network interactions involved in the amplification of visual cortical activity when viewing aversively conditioned cues. To generate a continuous neural signal from pericalcarine visual cortex, we presented rhythmic (10/sec) phase-reversing gratings, the orientation of which predicted the presence (CS+) or absence (CS-) of a cutaneous electric shock (i.e., the unconditioned stimulus). The resulting single trial steady-state visual evoked potential (ssVEP) amplitude was regressed against the whole-brain BOLD signal, resulting in a measure of ssVEP-BOLD coupling. Across all trial types, ssVEP-BOLD coupling was observed in both primary and extended visual cortical regions, the rolandic operculum, as well as the thalamus and bilateral hippocampus. For CS+ relative to CS- trials during the conditioning phase, BOLD-alone analyses showed CS+ enhancement at the occipital pole, superior temporal sulci, and the anterior insula bilaterally, whereas ssVEP-BOLD coupling was greater in the pericalcarine cortex, inferior parietal cortex, and middle frontal gyrus. Dynamic causal modeling analyses supported connectivity models in which heightened activity in pericalcarine cortex for threat (CS+) arises from cortico-cortical top-down modulation, specifically from the middle frontal gyrus. No evidence was observed for selective pericalcarine modulation by deep cortical structures such as the amygdala or anterior insula, suggesting that the heightened engagement of pericalcarine cortex for threat stimuli is mediated by cortical structures that constitute key nodes of canonical attention networks.

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Authors+Show Affiliations

Petro NM
1 University of Florida.
Gruss LF
1 University of Florida.
Yin S
1 University of Florida.
Huang H
1 University of Florida.
Miskovic V
2 SUNY Binghamton.
Ding M
1 University of Florida.
Keil A
1 University of Florida.

MeSH

AdultConditioning, ClassicalElectroencephalographyEvoked Potentials, VisualFearFemaleFrontal LobeFunctional NeuroimagingHippocampusHumansMagnetic Resonance ImagingMaleMultimodal ImagingParietal LobePattern Recognition, VisualThalamusVisual CortexYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28253082

Citation

Petro, Nathan M., et al. "Multimodal Imaging Evidence for a Frontoparietal Modulation of Visual Cortex During the Selective Processing of Conditioned Threat." Journal of Cognitive Neuroscience, vol. 29, no. 6, 2017, pp. 953-967.
Petro NM, Gruss LF, Yin S, et al. Multimodal Imaging Evidence for a Frontoparietal Modulation of Visual Cortex during the Selective Processing of Conditioned Threat. J Cogn Neurosci. 2017;29(6):953-967.
Petro, N. M., Gruss, L. F., Yin, S., Huang, H., Miskovic, V., Ding, M., & Keil, A. (2017). Multimodal Imaging Evidence for a Frontoparietal Modulation of Visual Cortex during the Selective Processing of Conditioned Threat. Journal of Cognitive Neuroscience, 29(6), 953-967. https://doi.org/10.1162/jocn_a_01114
Petro NM, et al. Multimodal Imaging Evidence for a Frontoparietal Modulation of Visual Cortex During the Selective Processing of Conditioned Threat. J Cogn Neurosci. 2017;29(6):953-967. PubMed PMID: 28253082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multimodal Imaging Evidence for a Frontoparietal Modulation of Visual Cortex during the Selective Processing of Conditioned Threat. AU - Petro,Nathan M, AU - Gruss,L Forest, AU - Yin,Siyang, AU - Huang,Haiqing, AU - Miskovic,Vladimir, AU - Ding,Mingzhou, AU - Keil,Andreas, Y1 - 2017/03/02/ PY - 2017/3/3/pubmed PY - 2018/3/2/medline PY - 2017/3/3/entrez SP - 953 EP - 967 JF - Journal of cognitive neuroscience JO - J Cogn Neurosci VL - 29 IS - 6 N2 - Emotionally salient cues are detected more readily, remembered better, and evoke greater visual cortical responses compared with neutral stimuli. The current study used concurrent EEG-fMRI recordings to identify large-scale network interactions involved in the amplification of visual cortical activity when viewing aversively conditioned cues. To generate a continuous neural signal from pericalcarine visual cortex, we presented rhythmic (10/sec) phase-reversing gratings, the orientation of which predicted the presence (CS+) or absence (CS-) of a cutaneous electric shock (i.e., the unconditioned stimulus). The resulting single trial steady-state visual evoked potential (ssVEP) amplitude was regressed against the whole-brain BOLD signal, resulting in a measure of ssVEP-BOLD coupling. Across all trial types, ssVEP-BOLD coupling was observed in both primary and extended visual cortical regions, the rolandic operculum, as well as the thalamus and bilateral hippocampus. For CS+ relative to CS- trials during the conditioning phase, BOLD-alone analyses showed CS+ enhancement at the occipital pole, superior temporal sulci, and the anterior insula bilaterally, whereas ssVEP-BOLD coupling was greater in the pericalcarine cortex, inferior parietal cortex, and middle frontal gyrus. Dynamic causal modeling analyses supported connectivity models in which heightened activity in pericalcarine cortex for threat (CS+) arises from cortico-cortical top-down modulation, specifically from the middle frontal gyrus. No evidence was observed for selective pericalcarine modulation by deep cortical structures such as the amygdala or anterior insula, suggesting that the heightened engagement of pericalcarine cortex for threat stimuli is mediated by cortical structures that constitute key nodes of canonical attention networks. SN - 1530-8898 UR - https://www.unboundmedicine.com/medline/citation/28253082/Multimodal_Imaging_Evidence_for_a_Frontoparietal_Modulation_of_Visual_Cortex_during_the_Selective_Processing_of_Conditioned_Threat_ DB - PRIME DP - Unbound Medicine ER -