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Metabolic effects of a low-glycemic-index diet.
Am J Clin Nutr 1987; 46(6):968-75AJ

Abstract

Six healthy male volunteers underwent 2-wk metabolically controlled high-glycemic-index (GI) and low-GI diets in random order. Over the low-GI diet significant reductions were seen in serum fructosamine (7.0 +/- 1.0%, p less than 0.01), 12-h blood glucose profile (37 +/- 7%, p less than 0.01), and total serum cholesterol (15 +/- 3%, p less than 0.01). As a measure of insulin secretion, 24-h urinary C-peptide levels were 32 +/- 10% lower (p less than 0.05) after the low-GI than after the high-GI diet. Lower C-peptide levels were maintained after a standard carbohydrate challenge after the low-GI diet despite higher blood glucose levels. Differences in blood glucose were not seen after a 5-g intravenous glucose challenge. These results are of interest with respect to the effect that prolonged postprandial reductions in nutrient fluxes and insulin secretion may have on carbohydrate and lipid metabolism and renal function.

Authors+Show Affiliations

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2825505

Citation

Jenkins, D J., et al. "Metabolic Effects of a Low-glycemic-index Diet." The American Journal of Clinical Nutrition, vol. 46, no. 6, 1987, pp. 968-75.
Jenkins DJ, Wolever TM, Collier GR, et al. Metabolic effects of a low-glycemic-index diet. Am J Clin Nutr. 1987;46(6):968-75.
Jenkins, D. J., Wolever, T. M., Collier, G. R., Ocana, A., Rao, A. V., Buckley, G., ... Thompson, L. U. (1987). Metabolic effects of a low-glycemic-index diet. The American Journal of Clinical Nutrition, 46(6), pp. 968-75.
Jenkins DJ, et al. Metabolic Effects of a Low-glycemic-index Diet. Am J Clin Nutr. 1987;46(6):968-75. PubMed PMID: 2825505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic effects of a low-glycemic-index diet. AU - Jenkins,D J, AU - Wolever,T M, AU - Collier,G R, AU - Ocana,A, AU - Rao,A V, AU - Buckley,G, AU - Lam,Y, AU - Mayer,A, AU - Thompson,L U, PY - 1987/12/1/pubmed PY - 1987/12/1/medline PY - 1987/12/1/entrez SP - 968 EP - 75 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 46 IS - 6 N2 - Six healthy male volunteers underwent 2-wk metabolically controlled high-glycemic-index (GI) and low-GI diets in random order. Over the low-GI diet significant reductions were seen in serum fructosamine (7.0 +/- 1.0%, p less than 0.01), 12-h blood glucose profile (37 +/- 7%, p less than 0.01), and total serum cholesterol (15 +/- 3%, p less than 0.01). As a measure of insulin secretion, 24-h urinary C-peptide levels were 32 +/- 10% lower (p less than 0.05) after the low-GI than after the high-GI diet. Lower C-peptide levels were maintained after a standard carbohydrate challenge after the low-GI diet despite higher blood glucose levels. Differences in blood glucose were not seen after a 5-g intravenous glucose challenge. These results are of interest with respect to the effect that prolonged postprandial reductions in nutrient fluxes and insulin secretion may have on carbohydrate and lipid metabolism and renal function. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/2825505/Metabolic_effects_of_a_low_glycemic_index_diet_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/46.6.968 DB - PRIME DP - Unbound Medicine ER -