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Drug-resistant parietal lobe epilepsy: clinical manifestations and surgery outcome.
Epileptic Disord 2017; 19(1):35-39ED

Abstract

We reviewed a large surgical cohort to investigate the clinical manifestations, EEG and neuroimaging findings, and postoperative seizure outcome in patients with drug-resistant parietal lobe epilepsy (PLE). All drug-resistant PLE patients, who were investigated for epilepsy surgery at Jefferson Comprehensive Epilepsy Center between 1986 and 2015, were identified. Demographic data, seizure data, EEG recordings, brain MRI, pathological findings, and postsurgical seizure outcome were reviewed. In total, 18 patients (11 males and seven females) were identified. Sixteen patients (88%) had tonic-clonic seizures, 12 (66%) had focal seizures with impaired awareness, and 13 (72%) described auras. Among 15 patients who had brain MRI, 14 patients (93%) had parietal lobe lesions. Only three of 15 patients (20%) who had interictal scalp EEG recordings showed parietal interictal spikes. Of 12 patients with available ictal surface EEG recordings, only three patients (25%) had parietal ictal EEG onset. After a mean follow-up duration of 8.6 years, 14 patients (77.7%) showed a favourable postoperative seizure outcome. In patients with PLE, semiology and EEG may be misleading and brain MRI is the most valuable tool to localize the epileptogenic zone. Postsurgical seizure outcome was favourable in our patients with drug-resistant parietal lobe epilepsy.

Authors+Show Affiliations

Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28256447

Citation

Asadollahi, Marjan, et al. "Drug-resistant Parietal Lobe Epilepsy: Clinical Manifestations and Surgery Outcome." Epileptic Disorders : International Epilepsy Journal With Videotape, vol. 19, no. 1, 2017, pp. 35-39.
Asadollahi M, Sperling MR, Rabiei AH, et al. Drug-resistant parietal lobe epilepsy: clinical manifestations and surgery outcome. Epileptic Disord. 2017;19(1):35-39.
Asadollahi, M., Sperling, M. R., Rabiei, A. H., & Asadi-Pooya, A. A. (2017). Drug-resistant parietal lobe epilepsy: clinical manifestations and surgery outcome. Epileptic Disorders : International Epilepsy Journal With Videotape, 19(1), pp. 35-39. doi:10.1684/epd.2017.0893.
Asadollahi M, et al. Drug-resistant Parietal Lobe Epilepsy: Clinical Manifestations and Surgery Outcome. Epileptic Disord. 2017 Mar 1;19(1):35-39. PubMed PMID: 28256447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug-resistant parietal lobe epilepsy: clinical manifestations and surgery outcome. AU - Asadollahi,Marjan, AU - Sperling,Michael R, AU - Rabiei,Amin H, AU - Asadi-Pooya,Ali A, PY - 2017/3/4/pubmed PY - 2017/7/25/medline PY - 2017/3/4/entrez KW - epilepsy KW - parietal lobe KW - seizure KW - surgery SP - 35 EP - 39 JF - Epileptic disorders : international epilepsy journal with videotape JO - Epileptic Disord VL - 19 IS - 1 N2 - We reviewed a large surgical cohort to investigate the clinical manifestations, EEG and neuroimaging findings, and postoperative seizure outcome in patients with drug-resistant parietal lobe epilepsy (PLE). All drug-resistant PLE patients, who were investigated for epilepsy surgery at Jefferson Comprehensive Epilepsy Center between 1986 and 2015, were identified. Demographic data, seizure data, EEG recordings, brain MRI, pathological findings, and postsurgical seizure outcome were reviewed. In total, 18 patients (11 males and seven females) were identified. Sixteen patients (88%) had tonic-clonic seizures, 12 (66%) had focal seizures with impaired awareness, and 13 (72%) described auras. Among 15 patients who had brain MRI, 14 patients (93%) had parietal lobe lesions. Only three of 15 patients (20%) who had interictal scalp EEG recordings showed parietal interictal spikes. Of 12 patients with available ictal surface EEG recordings, only three patients (25%) had parietal ictal EEG onset. After a mean follow-up duration of 8.6 years, 14 patients (77.7%) showed a favourable postoperative seizure outcome. In patients with PLE, semiology and EEG may be misleading and brain MRI is the most valuable tool to localize the epileptogenic zone. Postsurgical seizure outcome was favourable in our patients with drug-resistant parietal lobe epilepsy. SN - 1950-6945 UR - https://www.unboundmedicine.com/medline/citation/28256447/Drug_resistant_parietal_lobe_epilepsy:_clinical_manifestations_and_surgery_outcome_ L2 - http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/epd.2017.0893 DB - PRIME DP - Unbound Medicine ER -