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Diagnostic performance of Japan NBI Expert Team classification for differentiation among noninvasive, superficially invasive, and deeply invasive colorectal neoplasia.
Gastrointest Endosc 2017; 86(4):700-709GE

Abstract

BACKGROUNDS AND AIMS

The Japan NBI Expert Team (JNET) classification is the first universal narrow-band imaging magnifying endoscopic classification of colorectal tumors. Considering each type in this classification, the diagnostic ability of Type 2B is the weakest. Generally, clinical behavior is believed to be different in each gross type of colorectal tumor. We evaluated the differences in the diagnostic performance of JNET classification for each gross type (polypoid and superficial) and examined whether the diagnostic performance of Type 2B could be improved by subtyping.

METHODS

We analyzed 2933 consecutive cases of colorectal lesions, including 136 hyperplastic polyps/sessile serrated polyps, 1926 low-grade dysplasias (LGDs), 571 high-grade dysplasias (HGDs), and 300 submucosal (SM) carcinomas. We classified lesions as polypoid and superficial type and compared the diagnostic performance of the classification system in each type. Additionally, we subtyped Type 2B into 2B-low and 2B-high based on the level of irregularity in surface and vessel patterns, and we evaluated the relationship between the subtypes and histology, as analyzed separately for polypoid and superficial types. We also estimated interobserver and intraobserver variability.

RESULTS

The diagnostic performance of JNET classification did not differ significantly between polypoid and superficial lesions. Ninety-nine percent of Type 2B-low lesions were LGDs, HGDs, or superficial submucosal invasive (SM-s) carcinomas. In contrast, 60% of Type 2B-high lesions were deep submucosal invasive (SM-d) carcinomas. The results were not different between each gross type. Interobserver and intraobserver agreements for Type 2B subtyping were good, with kappa values of .743 and .786, respectively.

CONCLUSIONS

Type 2B subtyping may be useful for identifying lesions that are appropriate for endoscopic resection. JNET classification and Type 2B sub classification are useful criteria, regardless of gross type.

Authors+Show Affiliations

Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan.Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan.Department of Human Sciences, Faculty of Humanities and Human Sciences, Hiroshima Shudo University, Hiroshima, Japan.Health Service Center, Hiroshima University, Hiroshima, Japan.Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28257790

Citation

Sumimoto, Kyoku, et al. "Diagnostic Performance of Japan NBI Expert Team Classification for Differentiation Among Noninvasive, Superficially Invasive, and Deeply Invasive Colorectal Neoplasia." Gastrointestinal Endoscopy, vol. 86, no. 4, 2017, pp. 700-709.
Sumimoto K, Tanaka S, Shigita K, et al. Diagnostic performance of Japan NBI Expert Team classification for differentiation among noninvasive, superficially invasive, and deeply invasive colorectal neoplasia. Gastrointest Endosc. 2017;86(4):700-709.
Sumimoto, K., Tanaka, S., Shigita, K., Hayashi, N., Hirano, D., Tamaru, Y., ... Chayama, K. (2017). Diagnostic performance of Japan NBI Expert Team classification for differentiation among noninvasive, superficially invasive, and deeply invasive colorectal neoplasia. Gastrointestinal Endoscopy, 86(4), pp. 700-709. doi:10.1016/j.gie.2017.02.018.
Sumimoto K, et al. Diagnostic Performance of Japan NBI Expert Team Classification for Differentiation Among Noninvasive, Superficially Invasive, and Deeply Invasive Colorectal Neoplasia. Gastrointest Endosc. 2017;86(4):700-709. PubMed PMID: 28257790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic performance of Japan NBI Expert Team classification for differentiation among noninvasive, superficially invasive, and deeply invasive colorectal neoplasia. AU - Sumimoto,Kyoku, AU - Tanaka,Shinji, AU - Shigita,Kenjiro, AU - Hayashi,Nana, AU - Hirano,Daiki, AU - Tamaru,Yuzuru, AU - Ninomiya,Yuki, AU - Oka,Shiro, AU - Arihiro,Koji, AU - Shimamoto,Fumio, AU - Yoshihara,Masaharu, AU - Chayama,Kazuaki, Y1 - 2017/02/28/ PY - 2016/08/20/received PY - 2017/02/16/accepted PY - 2017/3/5/pubmed PY - 2018/5/31/medline PY - 2017/3/5/entrez SP - 700 EP - 709 JF - Gastrointestinal endoscopy JO - Gastrointest. Endosc. VL - 86 IS - 4 N2 - BACKGROUNDS AND AIMS: The Japan NBI Expert Team (JNET) classification is the first universal narrow-band imaging magnifying endoscopic classification of colorectal tumors. Considering each type in this classification, the diagnostic ability of Type 2B is the weakest. Generally, clinical behavior is believed to be different in each gross type of colorectal tumor. We evaluated the differences in the diagnostic performance of JNET classification for each gross type (polypoid and superficial) and examined whether the diagnostic performance of Type 2B could be improved by subtyping. METHODS: We analyzed 2933 consecutive cases of colorectal lesions, including 136 hyperplastic polyps/sessile serrated polyps, 1926 low-grade dysplasias (LGDs), 571 high-grade dysplasias (HGDs), and 300 submucosal (SM) carcinomas. We classified lesions as polypoid and superficial type and compared the diagnostic performance of the classification system in each type. Additionally, we subtyped Type 2B into 2B-low and 2B-high based on the level of irregularity in surface and vessel patterns, and we evaluated the relationship between the subtypes and histology, as analyzed separately for polypoid and superficial types. We also estimated interobserver and intraobserver variability. RESULTS: The diagnostic performance of JNET classification did not differ significantly between polypoid and superficial lesions. Ninety-nine percent of Type 2B-low lesions were LGDs, HGDs, or superficial submucosal invasive (SM-s) carcinomas. In contrast, 60% of Type 2B-high lesions were deep submucosal invasive (SM-d) carcinomas. The results were not different between each gross type. Interobserver and intraobserver agreements for Type 2B subtyping were good, with kappa values of .743 and .786, respectively. CONCLUSIONS: Type 2B subtyping may be useful for identifying lesions that are appropriate for endoscopic resection. JNET classification and Type 2B sub classification are useful criteria, regardless of gross type. SN - 1097-6779 UR - https://www.unboundmedicine.com/medline/citation/28257790/Diagnostic_performance_of_Japan_NBI_Expert_Team_classification_for_differentiation_among_noninvasive_superficially_invasive_and_deeply_invasive_colorectal_neoplasia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5107(17)30120-7 DB - PRIME DP - Unbound Medicine ER -