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Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study.
Psychiatry Res. 2017 06; 252:94-101.PR

Abstract

Many cytochrome p450-derived lipids promote resolution of inflammation, in contrast to their soluble epoxide hydrolase(sEH)-derived oxylipin breakdown products. Here we compare plasma oxylipins and precursor fatty acids between seasons in participants with major depressive disorder with seasonal pattern (MDD-s). Euthymic participants with a history of MDD-s recruited in summer-fall were followed-up in winter. At both visits, a structured clinical interview (DSM-5 criteria) and the Beck Depression Inventory II (BDI-II) were administered. Unesterified and total oxylipin pools were assayed by liquid chromatography tandem mass-spectrometry (LC-MS/MS). Precursor fatty acids were measured by gas chromatography. In nine unmedicated participants euthymic at baseline who met depression criteria in winter, BDI-II scores increased from 4.9±4.4 to 19.9±7.7. Four sEH-derived oxylipins increased in winter compared to summer-fall with moderate to large effect sizes. An auto-oxidation product (unesterified epoxyketooctadecadienoic acid) and lipoxygenase-derived 13-hydroxyoctadecadienoic acid also increased in winter. The cytochrome p450-derived 20-COOH-leukotriene B4 (unesterified) and total 14(15)-epoxyeicosatetraenoic acid, and the sEH-derived 14,15-dihydroxyeicostrienoic acid (unesterified), decreased in winter. We conclude that winter depression was associated with changes in cytochrome p450- and sEH-derived oxylipins, suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD-s.

Authors+Show Affiliations

Department of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA. Electronic address: mhennebelle@ucdavis.edu.Department of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA; Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan. Electronic address: yotoki@ucdavis.edu.Department of Entomology and Nematology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA. Electronic address: junyang@ucdavis.edu.Department of Entomology and Nematology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA. Electronic address: bdhammock@ucdavis.edu.Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada. Electronic address: anthony.levitt@sunnybrook.ca.Department of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, CA, USA. Electronic address: ataha@ucdavis.edu.Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON Canada. Electronic address: w.swardfager@utoronto.ca.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28259037

Citation

Hennebelle, Marie, et al. "Altered Soluble Epoxide Hydrolase-derived Oxylipins in Patients With Seasonal Major Depression: an Exploratory Study." Psychiatry Research, vol. 252, 2017, pp. 94-101.
Hennebelle M, Otoki Y, Yang J, et al. Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study. Psychiatry Res. 2017;252:94-101.
Hennebelle, M., Otoki, Y., Yang, J., Hammock, B. D., Levitt, A. J., Taha, A. Y., & Swardfager, W. (2017). Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study. Psychiatry Research, 252, 94-101. https://doi.org/10.1016/j.psychres.2017.02.056
Hennebelle M, et al. Altered Soluble Epoxide Hydrolase-derived Oxylipins in Patients With Seasonal Major Depression: an Exploratory Study. Psychiatry Res. 2017;252:94-101. PubMed PMID: 28259037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study. AU - Hennebelle,Marie, AU - Otoki,Yurika, AU - Yang,Jun, AU - Hammock,Bruce D, AU - Levitt,Anthony J, AU - Taha,Ameer Y, AU - Swardfager,Walter, Y1 - 2017/02/27/ PY - 2016/10/24/received PY - 2017/02/10/revised PY - 2017/02/24/accepted PY - 2017/3/5/pubmed PY - 2018/1/11/medline PY - 2017/3/5/entrez KW - Cytochrome p450 KW - Depression KW - Fatty acids KW - Lipidomics KW - Omega-3 KW - Omega-6 KW - Oxylipins KW - Seasonal major depression KW - Soluble epoxide hydrolase SP - 94 EP - 101 JF - Psychiatry research JO - Psychiatry Res VL - 252 N2 - Many cytochrome p450-derived lipids promote resolution of inflammation, in contrast to their soluble epoxide hydrolase(sEH)-derived oxylipin breakdown products. Here we compare plasma oxylipins and precursor fatty acids between seasons in participants with major depressive disorder with seasonal pattern (MDD-s). Euthymic participants with a history of MDD-s recruited in summer-fall were followed-up in winter. At both visits, a structured clinical interview (DSM-5 criteria) and the Beck Depression Inventory II (BDI-II) were administered. Unesterified and total oxylipin pools were assayed by liquid chromatography tandem mass-spectrometry (LC-MS/MS). Precursor fatty acids were measured by gas chromatography. In nine unmedicated participants euthymic at baseline who met depression criteria in winter, BDI-II scores increased from 4.9±4.4 to 19.9±7.7. Four sEH-derived oxylipins increased in winter compared to summer-fall with moderate to large effect sizes. An auto-oxidation product (unesterified epoxyketooctadecadienoic acid) and lipoxygenase-derived 13-hydroxyoctadecadienoic acid also increased in winter. The cytochrome p450-derived 20-COOH-leukotriene B4 (unesterified) and total 14(15)-epoxyeicosatetraenoic acid, and the sEH-derived 14,15-dihydroxyeicostrienoic acid (unesterified), decreased in winter. We conclude that winter depression was associated with changes in cytochrome p450- and sEH-derived oxylipins, suggesting that seasonal shifts in omega-6 and omega-3 fatty acid metabolism mediated by sEH may underlie inflammatory states in symptomatic MDD-s. SN - 1872-7123 UR - https://www.unboundmedicine.com/medline/citation/28259037/Altered_soluble_epoxide_hydrolase_derived_oxylipins_in_patients_with_seasonal_major_depression:_An_exploratory_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(16)31808-X DB - PRIME DP - Unbound Medicine ER -