TY - JOUR T1 - Delayed hematologic toxicity following rattlesnake envenomation unresponsive to crotalidae polyvalent antivenom. AU - Bailey,Abby M, AU - Justice,Stephanie, AU - Davis,George A, AU - Weant,Kyle, Y1 - 2017/02/27/ PY - 2017/02/13/received PY - 2017/02/25/accepted PY - 2017/3/6/pubmed PY - 2017/10/5/medline PY - 2017/3/6/entrez KW - Crotalidae polyvalent immune Fab KW - Delayed coagulopathy KW - Envenomation KW - Thrombocytopenia SP - 1038.e1 EP - 1038.e2 JF - The American journal of emergency medicine JO - Am J Emerg Med VL - 35 IS - 7 N2 - North American rattlesnake envenomations are known to produce coagulopathies and thrombocytopenia. However, the occurrence of delayed hematologic toxicity (less than seven days after envenomation) is poorly characterized in the medical literature. While the recurrence of hematologic derangements has been documented following envenomation, it is usually in the absence of clinically significant bleeding. Although commonly recommended to treat delayed coagulopathies, the effectiveness of crotalidae polyvalent immune Fab ovine (CroFab®) in managing this condition remains in question and warrants further investigation and exploration. We describe the case of a 19-year-old male who presented following rattlesnake envenomation at a church service who was treated with antivenin for 48 h and discharged home only to return four days later with profound thrombocytopenia, coagulopathy, and clinically significant bleeding. SN - 1532-8171 UR - https://www.unboundmedicine.com/medline/citation/28259369/Delayed_hematologic_toxicity_following_rattlesnake_envenomation_unresponsive_to_crotalidae_polyvalent_antivenom_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-6757(17)30159-6 DB - PRIME DP - Unbound Medicine ER -