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Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study).
Toxicol In Vitro. 2017 Jun; 41:143-149.TV

Abstract

Bisphenol A (BPA) and its analogs are widely used in the production of various everyday use products, which leads to a common exposure of humans to these substances. The effect of bisphenols on oxidative stress parameters has not been described in detail in non-nucleated cells, therefore, we have decided to evaluate the impact of BPA and its analogs, i.e. bisphenol S (BPS), bisphenol F (BPF) and bisphenol AF (BPAF) on reactive oxygen species (ROS) formation, lipid peroxidation, glutathione (GSH) level and the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in human erythrocytes. The erythrocytes were incubated with the compounds studied in the concentrations ranging from 0.1 to 500μg/ml for 1, 4 or 24h. It has been found that bisphenols enhanced ROS (including •OH) formation, depleted GSH level, increased lipid peroxidation and changed the activities of SOD, CAT and GSH-Px. It has been noted that the strongest alterations in ROS formation, lipid peroxidation and the activity of antioxidant enzymes were induced by BPAF, which changed CAT and SOD activity even at 0.5μg/ml. It has also been shown that BPA caused the strongest changes in GSH level, while BPS, which is the main BPA substituent in the manufacture did not alter most parameters studied.

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Authors+Show Affiliations

Maćczak A
Department of Biophysics of Environmental Pollution, Faculty of Biology and Environmental Protection, University of Łódź, Pomorska 141/143 St. 90-001 Łódź, Poland.
Cyrkler M
Department of Biophysics of Environmental Pollution, Faculty of Biology and Environmental Protection, University of Łódź, Pomorska 141/143 St. 90-001 Łódź, Poland.
Bukowska B
Department of Biophysics of Environmental Pollution, Faculty of Biology and Environmental Protection, University of Łódź, Pomorska 141/143 St. 90-001 Łódź, Poland.
Michałowicz J
Department of Biophysics of Environmental Pollution, Faculty of Biology and Environmental Protection, University of Łódź, Pomorska 141/143 St. 90-001 Łódź, Poland. Electronic address: michalow@biol.uni.lodz.pl.

MeSH

Benzhydryl CompoundsCatalaseCells, CulturedErythrocytesGlutathioneGlutathione PeroxidaseHumansLipid PeroxidationOxidative StressPhenolsReactive Oxygen SpeciesSuperoxide Dismutase

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28259788

Citation

Maćczak, Aneta, et al. "Bisphenol A, Bisphenol S, Bisphenol F and Bisphenol AF Induce Different Oxidative Stress and Damage in Human Red Blood Cells (in Vitro Study)." Toxicology in Vitro : an International Journal Published in Association With BIBRA, vol. 41, 2017, pp. 143-149.
Maćczak A, Cyrkler M, Bukowska B, et al. Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study). Toxicol In Vitro. 2017;41:143-149.
Maćczak, A., Cyrkler, M., Bukowska, B., & Michałowicz, J. (2017). Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study). Toxicology in Vitro : an International Journal Published in Association With BIBRA, 41, 143-149. https://doi.org/10.1016/j.tiv.2017.02.018
Maćczak A, et al. Bisphenol A, Bisphenol S, Bisphenol F and Bisphenol AF Induce Different Oxidative Stress and Damage in Human Red Blood Cells (in Vitro Study). Toxicol In Vitro. 2017;41:143-149. PubMed PMID: 28259788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study). AU - Maćczak,Aneta, AU - Cyrkler,Monika, AU - Bukowska,Bożena, AU - Michałowicz,Jaromir, Y1 - 2017/03/01/ PY - 2016/09/19/received PY - 2017/02/06/revised PY - 2017/02/20/accepted PY - 2017/3/6/pubmed PY - 2018/3/23/medline PY - 2017/3/6/entrez KW - Antioxidant enzymes KW - Bisphenols KW - Erythrocytes KW - Lipid peroxidation KW - Reactive oxygen species KW - Reduced glutathione SP - 143 EP - 149 JF - Toxicology in vitro : an international journal published in association with BIBRA JO - Toxicol In Vitro VL - 41 N2 - Bisphenol A (BPA) and its analogs are widely used in the production of various everyday use products, which leads to a common exposure of humans to these substances. The effect of bisphenols on oxidative stress parameters has not been described in detail in non-nucleated cells, therefore, we have decided to evaluate the impact of BPA and its analogs, i.e. bisphenol S (BPS), bisphenol F (BPF) and bisphenol AF (BPAF) on reactive oxygen species (ROS) formation, lipid peroxidation, glutathione (GSH) level and the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in human erythrocytes. The erythrocytes were incubated with the compounds studied in the concentrations ranging from 0.1 to 500μg/ml for 1, 4 or 24h. It has been found that bisphenols enhanced ROS (including •OH) formation, depleted GSH level, increased lipid peroxidation and changed the activities of SOD, CAT and GSH-Px. It has been noted that the strongest alterations in ROS formation, lipid peroxidation and the activity of antioxidant enzymes were induced by BPAF, which changed CAT and SOD activity even at 0.5μg/ml. It has also been shown that BPA caused the strongest changes in GSH level, while BPS, which is the main BPA substituent in the manufacture did not alter most parameters studied. SN - 1879-3177 UR - https://www.unboundmedicine.com/medline/citation/28259788/Bisphenol_A_bisphenol_S_bisphenol_F_and_bisphenol_AF_induce_different_oxidative_stress_and_damage_in_human_red_blood_cells__in_vitro_study__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0887-2333(17)30040-1 DB - PRIME DP - Unbound Medicine ER -