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Urine methanol concentration and alcohol hangover severity.
Alcohol 2017; 59:37-41A

Abstract

BACKGROUND

Congeners are substances, other than ethanol, that are produced during fermentation. Previous research found that the consumption of congener-rich drinks contributes to the severity of alcohol hangover. Methanol is such a congener that has been related to alcohol hangover. Therefore, the aim of this study was to examine the relationship between urine methanol concentration and alcohol hangover severity.

METHODS

N = 36 healthy social drinkers (22 females, 14 males), aged 18-30 years old, participated in a naturalistic study, comprising a hangover day and a control day (no alcohol consumed the previous day). N = 18 of them had regular hangovers (the hangover group), while the other N = 18 claimed to be hangover-immune (hangover-immune group). Overall hangover severity was assessed, and that of 23 individual hangover symptoms. Urine methanol concentrations on the hangover and control days were compared, and correlated to hangover (symptom) severity.

RESULTS

Urine methanol concentration was significantly higher on hangover days compared to control days (p = 0.0001). No significant differences in urine methanol concentration were found between the hangover group and hangover-immune group. However, urine methanol concentration did not significantly correlate with overall hangover severity (r = -0.011, p = 0.948), nor with any of the individual hangover symptoms. These findings were observed also when analyzing the data separately for the hangover-immune group. In the hangover group, a significant correlation with urine methanol concentration was found only with vomiting (r = 0.489, p = 0.037).

CONCLUSION

No significant correlation was observed between urine methanol concentration and hangover severity, nor with individual core hangover symptoms.

Authors+Show Affiliations

Division of Pharmacology, Utrecht University, Utrecht, The Netherlands.Division of Pharmacology, Utrecht University, Utrecht, The Netherlands.Division of Pharmacology, Utrecht University, Utrecht, The Netherlands.Division of Pharmacology, Utrecht University, Utrecht, The Netherlands.Division of Pharmacology, Utrecht University, Utrecht, The Netherlands.Division of Pharmacology, Utrecht University, Utrecht, The Netherlands.Faculty of Behavioral and Social Sciences, Groningen University, Groningen, The Netherlands.Division of Pharmacology, Utrecht University, Utrecht, The Netherlands; Nutricia Research, Utrecht, The Netherlands.Division of Pharmacology, Utrecht University, Utrecht, The Netherlands; Centre for Human Psychopharmacology, Swinburne University, Melbourne, Australia. Electronic address: j.c.verster@uu.nl.

Pub Type(s)

Journal Article
Observational Study
Pragmatic Clinical Trial

Language

eng

PubMed ID

28262186

Citation

Mackus, M, et al. "Urine Methanol Concentration and Alcohol Hangover Severity." Alcohol (Fayetteville, N.Y.), vol. 59, 2017, pp. 37-41.
Mackus M, Van de Loo AJ, Korte-Bouws GA, et al. Urine methanol concentration and alcohol hangover severity. Alcohol. 2017;59:37-41.
Mackus, M., Van de Loo, A. J., Korte-Bouws, G. A., Van Neer, R. H., Wang, X., Nguyen, T. T., ... Verster, J. C. (2017). Urine methanol concentration and alcohol hangover severity. Alcohol (Fayetteville, N.Y.), 59, pp. 37-41. doi:10.1016/j.alcohol.2016.12.004.
Mackus M, et al. Urine Methanol Concentration and Alcohol Hangover Severity. Alcohol. 2017;59:37-41. PubMed PMID: 28262186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urine methanol concentration and alcohol hangover severity. AU - Mackus,M, AU - Van de Loo,A J A E, AU - Korte-Bouws,G A H, AU - Van Neer,R H P, AU - Wang,X, AU - Nguyen,T T, AU - Brookhuis,K A, AU - Garssen,J, AU - Verster,J C, Y1 - 2016/12/14/ PY - 2016/06/17/received PY - 2016/10/01/revised PY - 2016/12/12/accepted PY - 2017/3/7/entrez PY - 2017/3/7/pubmed PY - 2018/1/4/medline KW - Alcohol KW - Congener KW - Hangover KW - Methanol KW - Severity KW - Urine SP - 37 EP - 41 JF - Alcohol (Fayetteville, N.Y.) JO - Alcohol VL - 59 N2 - BACKGROUND: Congeners are substances, other than ethanol, that are produced during fermentation. Previous research found that the consumption of congener-rich drinks contributes to the severity of alcohol hangover. Methanol is such a congener that has been related to alcohol hangover. Therefore, the aim of this study was to examine the relationship between urine methanol concentration and alcohol hangover severity. METHODS: N = 36 healthy social drinkers (22 females, 14 males), aged 18-30 years old, participated in a naturalistic study, comprising a hangover day and a control day (no alcohol consumed the previous day). N = 18 of them had regular hangovers (the hangover group), while the other N = 18 claimed to be hangover-immune (hangover-immune group). Overall hangover severity was assessed, and that of 23 individual hangover symptoms. Urine methanol concentrations on the hangover and control days were compared, and correlated to hangover (symptom) severity. RESULTS: Urine methanol concentration was significantly higher on hangover days compared to control days (p = 0.0001). No significant differences in urine methanol concentration were found between the hangover group and hangover-immune group. However, urine methanol concentration did not significantly correlate with overall hangover severity (r = -0.011, p = 0.948), nor with any of the individual hangover symptoms. These findings were observed also when analyzing the data separately for the hangover-immune group. In the hangover group, a significant correlation with urine methanol concentration was found only with vomiting (r = 0.489, p = 0.037). CONCLUSION: No significant correlation was observed between urine methanol concentration and hangover severity, nor with individual core hangover symptoms. SN - 1873-6823 UR - https://www.unboundmedicine.com/medline/citation/28262186/Urine_methanol_concentration_and_alcohol_hangover_severity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0741-8329(16)30153-7 DB - PRIME DP - Unbound Medicine ER -