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Paradoxical reactions elicited by diazepam in children with classic autism.

Abstract

Administration of diazepam (10 mg i.m.) to seven children (two girls and five boys) affected by infantile autism elicited paradoxical behavioural responses. Mainly, anxiogenic effect, unsocialized aggressive behaviour and explosive aggression were dramatically increased in comparison with the same symptoms present before and after treatment. The results show for the first time that benzodiazepines may elicit paradoxical behavioural response in autistic children. The possible involvement of an altered function at the level of GABA/benzodiazepine receptor complex is discussed.

Authors+Show Affiliations

,

Institute of Neurology, University of Cagliari, Italy.

, ,

Source

Functional neurology 2:3 pg 355-61

MeSH

Aggression
Attention Deficit Disorder with Hyperactivity
Autistic Disorder
Child
Diazepam
Female
Humans
Male
Receptors, GABA-A

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2826308

Citation

TY - JOUR T1 - Paradoxical reactions elicited by diazepam in children with classic autism. AU - Marrosu,F, AU - Marrosu,G, AU - Rachel,M G, AU - Biggio,G, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez SP - 355 EP - 61 JF - Functional neurology JO - Funct. Neurol. VL - 2 IS - 3 N2 - Administration of diazepam (10 mg i.m.) to seven children (two girls and five boys) affected by infantile autism elicited paradoxical behavioural responses. Mainly, anxiogenic effect, unsocialized aggressive behaviour and explosive aggression were dramatically increased in comparison with the same symptoms present before and after treatment. The results show for the first time that benzodiazepines may elicit paradoxical behavioural response in autistic children. The possible involvement of an altered function at the level of GABA/benzodiazepine receptor complex is discussed. SN - 0393-5264 UR - https://www.unboundmedicine.com/medline/citation/2826308/Paradoxical_reactions_elicited_by_diazepam_in_children_with_classic_autism_ L2 - http://www.diseaseinfosearch.org/result/673 ER -