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Cannabinoid signaling in health and disease.

Abstract

Cannabis sativa has long been used for medicinal purposes. To improve safety and efficacy, compounds from C. sativa were purified or synthesized and named under an umbrella group as cannabinoids. Currently, several cannabinoids may be prescribed in Canada for a variety of indications such as nausea and pain. More recently, an increasing number of reports suggest other salutary effects associated with endogenous cannabinoid signaling including cardioprotection. The therapeutic potential of cannabinoids is therefore extended; however, evidence is limited and mechanisms remain unclear. In addition, the use of cannabinoids clinically has been hindered due to pronounced psychoactive side effects. This review provides an overview on the endocannabinoid system, including known physiological roles, and conditions in which cannabinoid receptor signaling has been implicated.

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  • Authors+Show Affiliations

    ,

    a College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB R3E 0T5, Canada. b Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada.

    a College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB R3E 0T5, Canada. b Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. c Department of Pharmacology and Therapeutics, Max Rady College of Medicine, University of Manitoba, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada.

    Source

    MeSH

    Affect
    Amidohydrolases
    Analgesics
    Animals
    Appetite Regulation
    Canada
    Cannabinoid Receptor Agonists
    Cannabinoid Receptor Antagonists
    Cannabinoids
    Cannabis
    Cardiovascular System
    Central Nervous System
    Endocannabinoids
    Humans
    Medical Marijuana
    Multiple Sclerosis
    Neoplasms
    Neurodegenerative Diseases
    Pain
    Receptors, Cannabinoid
    Signal Transduction
    Sleep
    Vomiting

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    28263083

    Citation

    Lu, Yan, and Hope D. Anderson. "Cannabinoid Signaling in Health and Disease." Canadian Journal of Physiology and Pharmacology, vol. 95, no. 4, 2017, pp. 311-327.
    Lu Y, Anderson HD. Cannabinoid signaling in health and disease. Can J Physiol Pharmacol. 2017;95(4):311-327.
    Lu, Y., & Anderson, H. D. (2017). Cannabinoid signaling in health and disease. Canadian Journal of Physiology and Pharmacology, 95(4), pp. 311-327. doi:10.1139/cjpp-2016-0346.
    Lu Y, Anderson HD. Cannabinoid Signaling in Health and Disease. Can J Physiol Pharmacol. 2017;95(4):311-327. PubMed PMID: 28263083.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cannabinoid signaling in health and disease. AU - Lu,Yan, AU - Anderson,Hope D, Y1 - 2017/03/06/ PY - 2017/3/7/pubmed PY - 2017/6/7/medline PY - 2017/3/7/entrez KW - 2-arachidonoylglycerol KW - 2-arachidonoylglycérol KW - FAAH KW - MAGL KW - anandamide KW - cannabinoid receptor KW - endocannabinoid KW - endocannabinoïde KW - récepteur des cannabinoïdes SP - 311 EP - 327 JF - Canadian journal of physiology and pharmacology JO - Can. J. Physiol. Pharmacol. VL - 95 IS - 4 N2 - Cannabis sativa has long been used for medicinal purposes. To improve safety and efficacy, compounds from C. sativa were purified or synthesized and named under an umbrella group as cannabinoids. Currently, several cannabinoids may be prescribed in Canada for a variety of indications such as nausea and pain. More recently, an increasing number of reports suggest other salutary effects associated with endogenous cannabinoid signaling including cardioprotection. The therapeutic potential of cannabinoids is therefore extended; however, evidence is limited and mechanisms remain unclear. In addition, the use of cannabinoids clinically has been hindered due to pronounced psychoactive side effects. This review provides an overview on the endocannabinoid system, including known physiological roles, and conditions in which cannabinoid receptor signaling has been implicated. SN - 1205-7541 UR - https://www.unboundmedicine.com/medline/citation/28263083/Cannabinoid_signaling_in_health_and_disease_ L2 - http://www.nrcresearchpress.com/doi/full/10.1139/cjpp-2016-0346?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -