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Endometriosis-associated changes in serum levels of interferons and chemokines.
Turk J Med Sci. 2017 Feb 27; 47(1):115-122.TJ

Abstract

BACKGROUND/AIM

The aim of the study was to evaluate the serum concentration of main chemokines and interferons in patients with diagnosed endometriosis.

MATERIALS AND METHODS

A total of 160 women were divided in two study groups (group 1 - endometriosis; group 2 - healthy women). Serum levels of IFN-α, IFN-γ, MCP-1, MIP-1α, MIP-1β, RANTES, eotaxin, IL-8, MIG, IP-10, and IL-17A were measured with Human Multiplex Cytokine Panels. Results. Serum levels of IFN-γ, MCP-1, and IL-8 were significantly higher (mean 14.03, 57.24, and 534.24, respectively, compared to 0.58, 20.51, and 259.82, respectively), and serum levels of IP-10 and eotaxin were significantly lower in women with endometriosis compared to the controls (mean 1.15 and 1.01, respectively, compared to 3.90 and 3.22, respectively). Conclusions. According to our results women with endometriosis have elevated levels IFN-γ, MCP-1, and IL-8, and lower serum levels of IP-10 and eotaxin, indicating unbalanced immune activity in endometriosis.

Authors+Show Affiliations

nd Obstetrics and Gynecology Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.Medical Informatics and Biostatistics Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.nd Obstetrics and Gynecology Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.nd Obstetrics and Gynecology Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.nd Obstetrics and Gynecology Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.nd Obstetrics and Gynecology Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28263477

Citation

Măluțan, Andrei Mihai, et al. "Endometriosis-associated Changes in Serum Levels of Interferons and Chemokines." Turkish Journal of Medical Sciences, vol. 47, no. 1, 2017, pp. 115-122.
Măluțan AM, Drugan T, Ciortea R, et al. Endometriosis-associated changes in serum levels of interferons and chemokines. Turk J Med Sci. 2017;47(1):115-122.
Măluțan, A. M., Drugan, T., Ciortea, R., Bucuri, C., Rada, M. P., & Mihu, D. (2017). Endometriosis-associated changes in serum levels of interferons and chemokines. Turkish Journal of Medical Sciences, 47(1), 115-122. https://doi.org/10.3906/sag-1507-185
Măluțan AM, et al. Endometriosis-associated Changes in Serum Levels of Interferons and Chemokines. Turk J Med Sci. 2017 Feb 27;47(1):115-122. PubMed PMID: 28263477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endometriosis-associated changes in serum levels of interferons and chemokines. AU - Măluțan,Andrei Mihai, AU - Drugan,Tudor, AU - Ciortea,Răzvan, AU - Bucuri,Carmen, AU - Rada,Maria Patricia, AU - Mihu,Dan, Y1 - 2017/02/27/ PY - 2015/07/29/received PY - 2016/05/09/accepted PY - 2017/3/7/entrez PY - 2017/3/7/pubmed PY - 2018/12/29/medline SP - 115 EP - 122 JF - Turkish journal of medical sciences JO - Turk J Med Sci VL - 47 IS - 1 N2 - BACKGROUND/AIM: The aim of the study was to evaluate the serum concentration of main chemokines and interferons in patients with diagnosed endometriosis. MATERIALS AND METHODS: A total of 160 women were divided in two study groups (group 1 - endometriosis; group 2 - healthy women). Serum levels of IFN-α, IFN-γ, MCP-1, MIP-1α, MIP-1β, RANTES, eotaxin, IL-8, MIG, IP-10, and IL-17A were measured with Human Multiplex Cytokine Panels. Results. Serum levels of IFN-γ, MCP-1, and IL-8 were significantly higher (mean 14.03, 57.24, and 534.24, respectively, compared to 0.58, 20.51, and 259.82, respectively), and serum levels of IP-10 and eotaxin were significantly lower in women with endometriosis compared to the controls (mean 1.15 and 1.01, respectively, compared to 3.90 and 3.22, respectively). Conclusions. According to our results women with endometriosis have elevated levels IFN-γ, MCP-1, and IL-8, and lower serum levels of IP-10 and eotaxin, indicating unbalanced immune activity in endometriosis. SN - 1300-0144 UR - https://www.unboundmedicine.com/medline/citation/28263477/Endometriosis_associated_changes_in_serum_levels_of_interferons_and_chemokines_ L2 - https://doi.org/10.3906/sag-1507-185 DB - PRIME DP - Unbound Medicine ER -