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Immunochemical Detection of α-Synuclein Autoantibodies in Parkinson's Disease: Correlation between Plasma and Cerebrospinal Fluid Levels.
ACS Chem Neurosci. 2017 06 21; 8(6):1170-1176.AC

Abstract

Autoantibodies to Parkinson's disease (PD) amyloidogenic protein, α-synuclein, were recognized as a prospective biomarker for early disease diagnostics, yet there is inconsistency in previous reports, potentially related to PD status. Therefore, plasma and cerebrospinal fluid (CSF) of the cross-sectional cohort of 60 individuals, including recently diagnosed PD patients with mild and moderate PD and age-matched controls, were examined by enzyme-linked immunosorbent assay (ELISA). Nonparametric statistics was used for data analysis. We found significantly elevated levels of α-synuclein autoantibodies in both plasma and CSF in mild PD compared to controls, followed by some decrease in moderate PD. Receiver operating characteristic and effect size analyses confirmed the diagnostic power of α-synuclein antibodies in both plasma and CSF. For the first time, we showed the correlation between plasma and CSF α-synuclein antibody levels for mild, moderate, and combined PD groups. This indicates the potentiality of α-synuclein antibodies as PD biomarker and the increased diagnostic power of their simultaneous analysis in plasma and CSF.

Authors+Show Affiliations

Department of Medical Biochemistry and Biophysics, Umeå University , Umeå 901 87, Sweden.Department of Medical Biochemistry and Biophysics, Umeå University , Umeå 901 87, Sweden. Department of General Chemistry, Sumy State University , Sumy 40000, Ukraine.Department of Pharmacology and Clinical Neuroscience, Umeå University , Umeå 901 87, Sweden.Department of Medical Biochemistry and Biophysics, Umeå University , Umeå 901 87, Sweden.

Pub Type(s)

Letter
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28263550

Citation

Horvath, Istvan, et al. "Immunochemical Detection of α-Synuclein Autoantibodies in Parkinson's Disease: Correlation Between Plasma and Cerebrospinal Fluid Levels." ACS Chemical Neuroscience, vol. 8, no. 6, 2017, pp. 1170-1176.
Horvath I, Iashchishyn IA, Forsgren L, et al. Immunochemical Detection of α-Synuclein Autoantibodies in Parkinson's Disease: Correlation between Plasma and Cerebrospinal Fluid Levels. ACS Chem Neurosci. 2017;8(6):1170-1176.
Horvath, I., Iashchishyn, I. A., Forsgren, L., & Morozova-Roche, L. A. (2017). Immunochemical Detection of α-Synuclein Autoantibodies in Parkinson's Disease: Correlation between Plasma and Cerebrospinal Fluid Levels. ACS Chemical Neuroscience, 8(6), 1170-1176. https://doi.org/10.1021/acschemneuro.7b00063
Horvath I, et al. Immunochemical Detection of α-Synuclein Autoantibodies in Parkinson's Disease: Correlation Between Plasma and Cerebrospinal Fluid Levels. ACS Chem Neurosci. 2017 06 21;8(6):1170-1176. PubMed PMID: 28263550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunochemical Detection of α-Synuclein Autoantibodies in Parkinson's Disease: Correlation between Plasma and Cerebrospinal Fluid Levels. AU - Horvath,Istvan, AU - Iashchishyn,Igor A, AU - Forsgren,Lars, AU - Morozova-Roche,Ludmilla A, Y1 - 2017/03/10/ PY - 2017/3/7/pubmed PY - 2018/5/2/medline PY - 2017/3/7/entrez KW - Biomarkers KW - Parkinson’s disease KW - blood plasma KW - cerebrospinal fluid KW - enzyme-linked immunosorbent assay (ELISA) KW - α-synuclein autoantibodies SP - 1170 EP - 1176 JF - ACS chemical neuroscience JO - ACS Chem Neurosci VL - 8 IS - 6 N2 - Autoantibodies to Parkinson's disease (PD) amyloidogenic protein, α-synuclein, were recognized as a prospective biomarker for early disease diagnostics, yet there is inconsistency in previous reports, potentially related to PD status. Therefore, plasma and cerebrospinal fluid (CSF) of the cross-sectional cohort of 60 individuals, including recently diagnosed PD patients with mild and moderate PD and age-matched controls, were examined by enzyme-linked immunosorbent assay (ELISA). Nonparametric statistics was used for data analysis. We found significantly elevated levels of α-synuclein autoantibodies in both plasma and CSF in mild PD compared to controls, followed by some decrease in moderate PD. Receiver operating characteristic and effect size analyses confirmed the diagnostic power of α-synuclein antibodies in both plasma and CSF. For the first time, we showed the correlation between plasma and CSF α-synuclein antibody levels for mild, moderate, and combined PD groups. This indicates the potentiality of α-synuclein antibodies as PD biomarker and the increased diagnostic power of their simultaneous analysis in plasma and CSF. SN - 1948-7193 UR - https://www.unboundmedicine.com/medline/citation/28263550/Immunochemical_Detection_of_α_Synuclein_Autoantibodies_in_Parkinson's_Disease:_Correlation_between_Plasma_and_Cerebrospinal_Fluid_Levels_ L2 - https://doi.org/10.1021/acschemneuro.7b00063 DB - PRIME DP - Unbound Medicine ER -