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Chemical Composition, In Vitro Antimicrobial, Free-Radical-Scavenging and Antioxidant Activities of the Essential Oil of Leucas inflata Benth.
Molecules. 2017 Feb 27; 22(3)M

Abstract

The essential oil of Leucas inflata Balf.f. (Lamiaceae), collected in Yemen, was analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) techniques. Forty-three components were recognized, representing 89.2% of the total oil. The L. inflata volatile oil was found to contain a high percentage of aliphatic acids (51.1%). Hexadecanoic acid (32.8%) and n-dodecanoic acid (7.8%) were identified as the major compounds. Oxygenated monoterpenes were distinguished as the second significant group of constituents (16.0%). Camphor (6.1%) and linalool (3.2%) were found to be the main components among the oxygenated monoterpenes. In addition, the volatile oil was assessed for its antimicrobial activity against four bacterial strains and one yeast species using broth micro-dilution assay for minimum inhibitory concentrations (MIC). In addition, antioxidant activity was measured utilizing the anti-radical activity of the sable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and β-Carotene-linoleic acid assays. The oil of L. inflata showed an excellent antibacterial activity against only the tested Gram-positive bacteria with a MIC-value of 0.81 mg/mL. Furthermore, the oil demonstrated, at a concentration of 1 mg/mL, a weak to moderate antiradical and antioxidant activity of 38% and 32%, respectively.

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Authors+Show Affiliations

Mothana RA
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. rmothana@ksu.edu.sa. Department of Pharmacognosy, Faculty of Pharmacy, Sana'a-University, P.O. Box 33039, Sana'a, Yemen. rmothana@ksu.edu.sa.
Noman OM
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. onoman@ksu.edu.sa.
Al-Sheddi ES
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ealsheddi@ksu.edu.sa.
Khaled JM
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. gkhaled@ksu.esu.sa.
Al-Said MS
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. msalsaid@ksu.edu.sa.
Al-Rehaily AJ
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ajalreha@ksu.edu.sa.

MeSH

Anti-Infective AgentsAntioxidantsFree Radical ScavengersGas Chromatography-Mass SpectrometryGram-Positive BacteriaLamiaceaeMicrobial Sensitivity TestsOils, VolatilePlant Oils

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28264464

Citation

Mothana, Ramzi A., et al. "Chemical Composition, in Vitro Antimicrobial, Free-Radical-Scavenging and Antioxidant Activities of the Essential Oil of Leucas Inflata Benth." Molecules (Basel, Switzerland), vol. 22, no. 3, 2017.
Mothana RA, Noman OM, Al-Sheddi ES, et al. Chemical Composition, In Vitro Antimicrobial, Free-Radical-Scavenging and Antioxidant Activities of the Essential Oil of Leucas inflata Benth. Molecules. 2017;22(3).
Mothana, R. A., Noman, O. M., Al-Sheddi, E. S., Khaled, J. M., Al-Said, M. S., & Al-Rehaily, A. J. (2017). Chemical Composition, In Vitro Antimicrobial, Free-Radical-Scavenging and Antioxidant Activities of the Essential Oil of Leucas inflata Benth. Molecules (Basel, Switzerland), 22(3). https://doi.org/10.3390/molecules22030367
Mothana RA, et al. Chemical Composition, in Vitro Antimicrobial, Free-Radical-Scavenging and Antioxidant Activities of the Essential Oil of Leucas Inflata Benth. Molecules. 2017 Feb 27;22(3) PubMed PMID: 28264464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical Composition, In Vitro Antimicrobial, Free-Radical-Scavenging and Antioxidant Activities of the Essential Oil of Leucas inflata Benth. AU - Mothana,Ramzi A, AU - Noman,Omar M, AU - Al-Sheddi,Ebtesam S, AU - Khaled,Jamal M, AU - Al-Said,Mansour S, AU - Al-Rehaily,Adnan J, Y1 - 2017/02/27/ PY - 2017/02/08/received PY - 2017/02/21/accepted PY - 2017/3/8/entrez PY - 2017/3/8/pubmed PY - 2017/5/10/medline KW - GC KW - GC/MS KW - Leucas inflata KW - antimicrobial KW - antioxidant KW - essential oil JF - Molecules (Basel, Switzerland) JO - Molecules VL - 22 IS - 3 N2 - The essential oil of Leucas inflata Balf.f. (Lamiaceae), collected in Yemen, was analyzed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) techniques. Forty-three components were recognized, representing 89.2% of the total oil. The L. inflata volatile oil was found to contain a high percentage of aliphatic acids (51.1%). Hexadecanoic acid (32.8%) and n-dodecanoic acid (7.8%) were identified as the major compounds. Oxygenated monoterpenes were distinguished as the second significant group of constituents (16.0%). Camphor (6.1%) and linalool (3.2%) were found to be the main components among the oxygenated monoterpenes. In addition, the volatile oil was assessed for its antimicrobial activity against four bacterial strains and one yeast species using broth micro-dilution assay for minimum inhibitory concentrations (MIC). In addition, antioxidant activity was measured utilizing the anti-radical activity of the sable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and β-Carotene-linoleic acid assays. The oil of L. inflata showed an excellent antibacterial activity against only the tested Gram-positive bacteria with a MIC-value of 0.81 mg/mL. Furthermore, the oil demonstrated, at a concentration of 1 mg/mL, a weak to moderate antiradical and antioxidant activity of 38% and 32%, respectively. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/28264464/Chemical_Composition_In_Vitro_Antimicrobial_Free_Radical_Scavenging_and_Antioxidant_Activities_of_the_Essential_Oil_of_Leucas_inflata_Benth_ DB - PRIME DP - Unbound Medicine ER -