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Effect of androgen on adrenal steroidogenesis in normal women.
J Clin Endocrinol Metab. 1988 Jan; 66(1):128-30.JC

Abstract

Ovarian hyperandrogenism may induce adrenal enzymatic defects that mimic true inherited disorders of adrenal hormone biosynthesis. To assess the effect of hyperandrogenism on adrenal steroidogenesis, seven normal ovulatory women were studied on 2 days during the early follicular phase of their cycles. Plasma 17-hydroxyprogesterone (17-Prog), 17-hydroxypregnenolone, dehydroepiandrosterone (DHEA), DHEA sulfate, androstenedione (Adione), testosterone (T), 11-deoxycortisol, and cortisol concentrations were measured every 15 min for 3 h after iv injection of 0.25 mg ACTH (day 1) and pretreatment with dexamethasone on each day. On the second study day, T (80 micrograms/h) was infused iv for 5 h, and ACTH was given after 2 h of T infusion. The T infusion raised mean serum T levels from 1.2 +/- 0.3 (+/- SE) to 8.6 +/- 0.6 nmol/L. The maximum incremental (delta max) plasma Adione response to ACTH was significantly higher (2.6 +/- 0.3 to 3.2 +/- 0.4 nmol/L; P less than 0.009) during the T infusion, while the delta max responses of the other steroids did not change. There was an increase in the delta max 17-Prog to cortisol ratio (4.9 +/- 0.7 to 7.0 +/- 1.0; P less than 0.05), but no change in the delta max 17-Prog to Adione or 17-hydroxypregnenolone to DHEA ratios and no changes in the delta max delta 5- to delta 4-steroid ratios. These data suggest that acute T elevations result in subtle inhibition of 21-and/or 11 beta-hydroxylase activities, but not in 17-20-desmolase or 3 beta-ol activities.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2826523

Citation

Vermesh, M, et al. "Effect of Androgen On Adrenal Steroidogenesis in Normal Women." The Journal of Clinical Endocrinology and Metabolism, vol. 66, no. 1, 1988, pp. 128-30.
Vermesh M, Silva PD, Rosen GF, et al. Effect of androgen on adrenal steroidogenesis in normal women. J Clin Endocrinol Metab. 1988;66(1):128-30.
Vermesh, M., Silva, P. D., Rosen, G. F., Vijod, A. G., & Lobo, R. A. (1988). Effect of androgen on adrenal steroidogenesis in normal women. The Journal of Clinical Endocrinology and Metabolism, 66(1), 128-30.
Vermesh M, et al. Effect of Androgen On Adrenal Steroidogenesis in Normal Women. J Clin Endocrinol Metab. 1988;66(1):128-30. PubMed PMID: 2826523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of androgen on adrenal steroidogenesis in normal women. AU - Vermesh,M, AU - Silva,P D, AU - Rosen,G F, AU - Vijod,A G, AU - Lobo,R A, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 128 EP - 30 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 66 IS - 1 N2 - Ovarian hyperandrogenism may induce adrenal enzymatic defects that mimic true inherited disorders of adrenal hormone biosynthesis. To assess the effect of hyperandrogenism on adrenal steroidogenesis, seven normal ovulatory women were studied on 2 days during the early follicular phase of their cycles. Plasma 17-hydroxyprogesterone (17-Prog), 17-hydroxypregnenolone, dehydroepiandrosterone (DHEA), DHEA sulfate, androstenedione (Adione), testosterone (T), 11-deoxycortisol, and cortisol concentrations were measured every 15 min for 3 h after iv injection of 0.25 mg ACTH (day 1) and pretreatment with dexamethasone on each day. On the second study day, T (80 micrograms/h) was infused iv for 5 h, and ACTH was given after 2 h of T infusion. The T infusion raised mean serum T levels from 1.2 +/- 0.3 (+/- SE) to 8.6 +/- 0.6 nmol/L. The maximum incremental (delta max) plasma Adione response to ACTH was significantly higher (2.6 +/- 0.3 to 3.2 +/- 0.4 nmol/L; P less than 0.009) during the T infusion, while the delta max responses of the other steroids did not change. There was an increase in the delta max 17-Prog to cortisol ratio (4.9 +/- 0.7 to 7.0 +/- 1.0; P less than 0.05), but no change in the delta max 17-Prog to Adione or 17-hydroxypregnenolone to DHEA ratios and no changes in the delta max delta 5- to delta 4-steroid ratios. These data suggest that acute T elevations result in subtle inhibition of 21-and/or 11 beta-hydroxylase activities, but not in 17-20-desmolase or 3 beta-ol activities. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/2826523/Effect_of_androgen_on_adrenal_steroidogenesis_in_normal_women_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-66-1-128 DB - PRIME DP - Unbound Medicine ER -