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A morphologic and morphometric study of cells from colloid carcinoma of the breast obtained by fine needle aspiration. Distinction from other breast lesions.
Acta Cytol. 1987 Nov-Dec; 31(6):742-50.AC

Abstract

Morphologic and morphometric studies were carried out on eight cases of pure and mixed colloid carcinoma of the breast initially diagnosed by fine needle aspiration (FNA). Key morphologic features included (1) cellular smears, (2) single cells, loose aggregates and cohesive groups of cells bathed in a mucinous background, (3) single cells displaying nuclear eccentricity and (4) little variation in nuclear size or shape, with bland-to-accentuated chromatin and rare nucleoli. These morphologic features are compared with those observed in pregnancy adenoma, lobular carcinoma, fibroadenoma, ductal carcinoma and medullary carcinoma. A morphometric study employing the major and minor axes of the nucleus, its axis product and axis ratio was also performed. Statistical treatment confirmed that the nuclear axis product (a size factor) distinguished colloid carcinoma from the other breast lesions, except the small-cell type of ductal carcinoma. Furthermore, the nuclear axis ratio (a shape factor) discriminates pregnancy adenoma and small-cell ductal carcinoma from the other breast lesions studied. By combining morphologic and morphometric criteria, one can specifically separate colloid carcinoma from the other breast lesions when examining smears obtained by FNA. Since colloid carcinoma is usually composed of cells with a relatively benign-appearing cytomorphology, the importance of recognizing this entity in fine needle aspirates is emphasized.

Authors+Show Affiliations

Department of Pathology, Harbor-UCLA Medical Center, Torrance.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2827410

Citation

Duane, G B., et al. "A Morphologic and Morphometric Study of Cells From Colloid Carcinoma of the Breast Obtained By Fine Needle Aspiration. Distinction From Other Breast Lesions." Acta Cytologica, vol. 31, no. 6, 1987, pp. 742-50.
Duane GB, Kanter MH, Branigan T, et al. A morphologic and morphometric study of cells from colloid carcinoma of the breast obtained by fine needle aspiration. Distinction from other breast lesions. Acta Cytol. 1987;31(6):742-50.
Duane, G. B., Kanter, M. H., Branigan, T., & Chang, C. (1987). A morphologic and morphometric study of cells from colloid carcinoma of the breast obtained by fine needle aspiration. Distinction from other breast lesions. Acta Cytologica, 31(6), 742-50.
Duane GB, et al. A Morphologic and Morphometric Study of Cells From Colloid Carcinoma of the Breast Obtained By Fine Needle Aspiration. Distinction From Other Breast Lesions. Acta Cytol. 1987 Nov-Dec;31(6):742-50. PubMed PMID: 2827410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A morphologic and morphometric study of cells from colloid carcinoma of the breast obtained by fine needle aspiration. Distinction from other breast lesions. AU - Duane,G B, AU - Kanter,M H, AU - Branigan,T, AU - Chang,C, PY - 1987/11/1/pubmed PY - 1987/11/1/medline PY - 1987/11/1/entrez SP - 742 EP - 50 JF - Acta cytologica JO - Acta Cytol VL - 31 IS - 6 N2 - Morphologic and morphometric studies were carried out on eight cases of pure and mixed colloid carcinoma of the breast initially diagnosed by fine needle aspiration (FNA). Key morphologic features included (1) cellular smears, (2) single cells, loose aggregates and cohesive groups of cells bathed in a mucinous background, (3) single cells displaying nuclear eccentricity and (4) little variation in nuclear size or shape, with bland-to-accentuated chromatin and rare nucleoli. These morphologic features are compared with those observed in pregnancy adenoma, lobular carcinoma, fibroadenoma, ductal carcinoma and medullary carcinoma. A morphometric study employing the major and minor axes of the nucleus, its axis product and axis ratio was also performed. Statistical treatment confirmed that the nuclear axis product (a size factor) distinguished colloid carcinoma from the other breast lesions, except the small-cell type of ductal carcinoma. Furthermore, the nuclear axis ratio (a shape factor) discriminates pregnancy adenoma and small-cell ductal carcinoma from the other breast lesions studied. By combining morphologic and morphometric criteria, one can specifically separate colloid carcinoma from the other breast lesions when examining smears obtained by FNA. Since colloid carcinoma is usually composed of cells with a relatively benign-appearing cytomorphology, the importance of recognizing this entity in fine needle aspirates is emphasized. SN - 0001-5547 UR - https://www.unboundmedicine.com/medline/citation/2827410/A_morphologic_and_morphometric_study_of_cells_from_colloid_carcinoma_of_the_breast_obtained_by_fine_needle_aspiration__Distinction_from_other_breast_lesions_ L2 - https://medlineplus.gov/breastcancer.html DB - PRIME DP - Unbound Medicine ER -