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Aortic depressor nerve stimulation does not impede the dynamic characteristics of the carotid sinus baroreflex in normotensive or spontaneously hypertensive rats.
. 2017 05 01; 312(5):R787-R796.

Abstract

Recent clinical trials in patients with drug-resistant hypertension indicate that electrical activation of the carotid sinus baroreflex can reduce arterial pressure (AP) for more than a year. To examine whether the electrical stimulation from one baroreflex system impedes normal short-term AP regulation via another unstimulated baroreflex system, we electrically stimulated the left aortic depressor nerve (ADN) while estimating the dynamic characteristics of the carotid sinus baroreflex in anesthetized normotensive Wistar-Kyoto (WKY; n = 8) rats and spontaneously hypertensive rats (SHR; n = 7). Isolated carotid sinus regions were perturbed for 20 min using a Gaussian white noise signal with a mean of 120 mmHg for WKY and 160 mmHg for SHR. Tonic ADN stimulation (2 Hz, 10 V, and 0.1-ms pulse width) decreased mean sympathetic nerve activity (73.4 ± 14.0 vs. 51.6 ± 11.3 arbitrary units in WKY, P = 0.012; and 248.7 ± 33.9 vs. 181.1 ± 16.6 arbitrary units in SHR, P = 0.018) and mean AP (90.8 ± 6.6 vs. 81.2 ± 5.4 mmHg in WKY, P = 0.004; and 128.6 ± 9.8 vs. 114.7 ± 10.3 mmHg in SHR, P = 0.009). The slope of dynamic gain in the neural arc transfer function from carotid sinus pressure to sympathetic nerve activity was not different between trials with and without the ADN stimulation (12.55 ± 0.93 vs. 13.03 ± 1.28 dB/decade in WKY, P = 0.542; and 17.37 ± 1.01 vs. 17.47 ± 1.64 dB/decade in SHR, P = 0.946). These results indicate that the tonic ADN stimulation does not significantly modify the dynamic characteristics of the carotid sinus baroreflex.

Authors+Show Affiliations

Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan torukawa@ncvc.go.jp.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28274940

Citation

Kawada, Toru, et al. "Aortic Depressor Nerve Stimulation Does Not Impede the Dynamic Characteristics of the Carotid Sinus Baroreflex in Normotensive or Spontaneously Hypertensive Rats." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol. 312, no. 5, 2017, pp. R787-R796.
Kawada T, Turner MJ, Shimizu S, et al. Aortic depressor nerve stimulation does not impede the dynamic characteristics of the carotid sinus baroreflex in normotensive or spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2017;312(5):R787-R796.
Kawada, T., Turner, M. J., Shimizu, S., Fukumitsu, M., Kamiya, A., & Sugimachi, M. (2017). Aortic depressor nerve stimulation does not impede the dynamic characteristics of the carotid sinus baroreflex in normotensive or spontaneously hypertensive rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 312(5), R787-R796. https://doi.org/10.1152/ajpregu.00530.2016
Kawada T, et al. Aortic Depressor Nerve Stimulation Does Not Impede the Dynamic Characteristics of the Carotid Sinus Baroreflex in Normotensive or Spontaneously Hypertensive Rats. Am J Physiol Regul Integr Comp Physiol. 2017 05 1;312(5):R787-R796. PubMed PMID: 28274940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aortic depressor nerve stimulation does not impede the dynamic characteristics of the carotid sinus baroreflex in normotensive or spontaneously hypertensive rats. AU - Kawada,Toru, AU - Turner,Michael J, AU - Shimizu,Shuji, AU - Fukumitsu,Masafumi, AU - Kamiya,Atsunori, AU - Sugimachi,Masaru, Y1 - 2017/03/08/ PY - 2016/12/14/received PY - 2017/02/06/revised PY - 2017/02/24/accepted PY - 2017/3/10/pubmed PY - 2017/8/26/medline PY - 2017/3/10/entrez KW - Gaussian white noise KW - arterial pressure KW - sympathetic nerve activity KW - transfer function SP - R787 EP - R796 JF - American journal of physiology. Regulatory, integrative and comparative physiology JO - Am. J. Physiol. Regul. Integr. Comp. Physiol. VL - 312 IS - 5 N2 - Recent clinical trials in patients with drug-resistant hypertension indicate that electrical activation of the carotid sinus baroreflex can reduce arterial pressure (AP) for more than a year. To examine whether the electrical stimulation from one baroreflex system impedes normal short-term AP regulation via another unstimulated baroreflex system, we electrically stimulated the left aortic depressor nerve (ADN) while estimating the dynamic characteristics of the carotid sinus baroreflex in anesthetized normotensive Wistar-Kyoto (WKY; n = 8) rats and spontaneously hypertensive rats (SHR; n = 7). Isolated carotid sinus regions were perturbed for 20 min using a Gaussian white noise signal with a mean of 120 mmHg for WKY and 160 mmHg for SHR. Tonic ADN stimulation (2 Hz, 10 V, and 0.1-ms pulse width) decreased mean sympathetic nerve activity (73.4 ± 14.0 vs. 51.6 ± 11.3 arbitrary units in WKY, P = 0.012; and 248.7 ± 33.9 vs. 181.1 ± 16.6 arbitrary units in SHR, P = 0.018) and mean AP (90.8 ± 6.6 vs. 81.2 ± 5.4 mmHg in WKY, P = 0.004; and 128.6 ± 9.8 vs. 114.7 ± 10.3 mmHg in SHR, P = 0.009). The slope of dynamic gain in the neural arc transfer function from carotid sinus pressure to sympathetic nerve activity was not different between trials with and without the ADN stimulation (12.55 ± 0.93 vs. 13.03 ± 1.28 dB/decade in WKY, P = 0.542; and 17.37 ± 1.01 vs. 17.47 ± 1.64 dB/decade in SHR, P = 0.946). These results indicate that the tonic ADN stimulation does not significantly modify the dynamic characteristics of the carotid sinus baroreflex. SN - 1522-1490 UR - https://www.unboundmedicine.com/medline/citation/28274940/Aortic_depressor_nerve_stimulation_does_not_impede_the_dynamic_characteristics_of_the_carotid_sinus_baroreflex_in_normotensive_or_spontaneously_hypertensive_rats_ L2 - https://journals.physiology.org/doi/10.1152/ajpregu.00530.2016?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -