TY - JOUR T1 - Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases. AU - Maurice,Tangui, AU - Goguadze,Nino, PY - 2017/3/10/pubmed PY - 2018/4/11/medline PY - 2017/3/10/entrez KW - Alzheimer’s disease KW - Amyotrophic lateral sclerosis KW - Huntington’s disease KW - Learning and memory KW - Multiple sclerosis KW - Neuroprotection KW - Parkinson’s disease KW - σ1 polymorphisms KW - σ1 receptor SP - 81 EP - 108 JF - Handbook of experimental pharmacology JO - Handb Exp Pharmacol VL - 244 N2 - The sigma-1 (σ1) receptor has been associated with regulation of intracellular Ca[2+] homeostasis, several cellular signaling pathways, and inter-organelle communication, in part through its chaperone activity. In vivo, agonists of the σ1 receptor enhance brain plasticity, with particularly well-described impact on learning and memory. Under pathological conditions, σ1 receptor agonists can induce cytoprotective responses. These protective responses comprise various complementary pathways that appear to be differentially engaged according to pathological mechanism. Recent studies have highlighted the efficacy of drugs that act through the σ1 receptor to mitigate symptoms associated with neurodegenerative disorders with distinct mechanisms of pathogenesis. Here, we will review genetic and pharmacological evidence of σ1 receptor engagement in learning and memory disorders, cognitive impairment, and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and Huntington's disease. SN - 0171-2004 UR - https://www.unboundmedicine.com/medline/citation/28275911/Sigma_1__��1__Receptor_in_Memory_and_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -