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Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats.
Behav Neurol. 2017; 2017:5091027.BN

Abstract

It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action of classical benzodiazepine drugs. To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test. We found that, even in the absence of chronic stress, the administration of a course of test substances changed anxiety indicators toward their deterioration, but the changes after the administration of a course of Selank were less pronounced. In conditions of chronic stress, anxiety indicator values after the simultaneous use of diazepam and Selank did not differ from the respective values observed before chronic stress exposure. The data obtained indicate that the individual administration of Selank was the most effective in reducing elevated levels of anxiety, induced by the administration of a course of test substances, whereas the combination of diazepam with Selank was the most effective in reducing anxiety in unpredictable chronic mild stress conditions.

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Authors+Show Affiliations

Kasian A
Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
Kolomin T
Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
Andreeva L
Department of Chemistry of Physiologically Active Compounds, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
Bondarenko E
Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
Myasoedov N
Department of Chemistry of Physiologically Active Compounds, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
Slominsky P
Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.
Shadrina M
Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, 2 Kurchatov Sq., Moscow 123182, Russia.

MeSH

AnimalsAnti-Anxiety AgentsAnxietyDiazepamDisease Models, AnimalMaleMotor ActivityOligopeptidesPeptidesRats, WistarStress, Physiological

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28280289

Citation

Kasian, Anastasiya, et al. "Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats." Behavioural Neurology, vol. 2017, 2017, p. 5091027.
Kasian A, Kolomin T, Andreeva L, et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol. 2017;2017:5091027.
Kasian, A., Kolomin, T., Andreeva, L., Bondarenko, E., Myasoedov, N., Slominsky, P., & Shadrina, M. (2017). Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behavioural Neurology, 2017, 5091027. https://doi.org/10.1155/2017/5091027
Kasian A, et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol. 2017;2017:5091027. PubMed PMID: 28280289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. AU - Kasian,Anastasiya, AU - Kolomin,Timur, AU - Andreeva,Lyudmila, AU - Bondarenko,Elena, AU - Myasoedov,Nikolay, AU - Slominsky,Petr, AU - Shadrina,Maria, Y1 - 2017/02/09/ PY - 2016/10/13/received PY - 2016/12/19/revised PY - 2017/01/16/accepted PY - 2017/3/11/entrez PY - 2017/3/11/pubmed PY - 2017/3/23/medline SP - 5091027 EP - 5091027 JF - Behavioural neurology JO - Behav Neurol VL - 2017 N2 - It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action of classical benzodiazepine drugs. To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test. We found that, even in the absence of chronic stress, the administration of a course of test substances changed anxiety indicators toward their deterioration, but the changes after the administration of a course of Selank were less pronounced. In conditions of chronic stress, anxiety indicator values after the simultaneous use of diazepam and Selank did not differ from the respective values observed before chronic stress exposure. The data obtained indicate that the individual administration of Selank was the most effective in reducing elevated levels of anxiety, induced by the administration of a course of test substances, whereas the combination of diazepam with Selank was the most effective in reducing anxiety in unpredictable chronic mild stress conditions. SN - 1875-8584 UR - https://www.unboundmedicine.com/medline/citation/28280289/Peptide_Selank_Enhances_the_Effect_of_Diazepam_in_Reducing_Anxiety_in_Unpredictable_Chronic_Mild_Stress_Conditions_in_Rats_ DB - PRIME DP - Unbound Medicine ER -