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Correlation between severity of clinical signs and transcranial magnetic motor evoked potentials in dogs with intervertebral disc herniation.
Vet J. 2017 Mar; 221:48-53.VJ

Abstract

Transcranial magnetic motor evoked potentials (TMMEPs) can assess the functional integrity of the spinal cord descending motor pathways. In intervertebral disc herniation (IVDH), these pathways are compromised to varying degrees reflected by the severity of neurological deficits. The hypotheses of this study were as follows: (1) TMMEPs differ in dogs with IVDH and healthy control dogs; (2) TMMEPs reflect different severities of neurological signs; and (3) TMMEPs can document functional motor improvement and therefore monitor recovery of function. TMMEPs were recorded in 50 dogs with thoracolumbar IVDH. Clinical signs ranged from spinal hyperesthesia to non-ambulatory paraparesis in 19 dogs and paraplegia with/without deep pain sensation in 31 dogs. In these 31 paraplegic dogs, transcranial magnetic stimulation (TMS) was repeated during follow-up examinations. Ten healthy Beagle dogs served as controls. There was a significant increase in onset latency and decrease in peak-to-peak amplitude in the pelvic limb TMMEPs of dogs with spinal hyperesthesia to severe paraparesis compared to control dogs. Waveforms in dogs with IVDH were predominantly polyphasic in contrast to the biphasic waveforms of the control dogs. TMMEPs could not be generated in the pelvic limbs of paraplegic dogs. However, TMMEPs with markedly increased onset latencies and decreased peak-to-peak amplitudes reappeared in the pelvic limbs of dogs that were paraplegic before surgery and showed functional motor improvement during follow-up. The severity of neurological deficits was reflected by TMMEP findings, which could be used to document functional motor recovery in IVDH. TMS could therefore be used as an ancillary test to monitor response to therapy in dogs during rehabilitation.

Authors+Show Affiliations

Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.Department of Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover, Hannover, Germany.Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany.Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Hannover, Germany. Electronic address: veronika.stein@vetsuisse.unibe.ch.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28283080

Citation

Amendt, H-L, et al. "Correlation Between Severity of Clinical Signs and Transcranial Magnetic Motor Evoked Potentials in Dogs With Intervertebral Disc Herniation." Veterinary Journal (London, England : 1997), vol. 221, 2017, pp. 48-53.
Amendt HL, Siedenburg JS, Steffensen N, et al. Correlation between severity of clinical signs and transcranial magnetic motor evoked potentials in dogs with intervertebral disc herniation. Vet J. 2017;221:48-53.
Amendt, H. L., Siedenburg, J. S., Steffensen, N., Kordass, U., Rohn, K., Tipold, A., & Stein, V. M. (2017). Correlation between severity of clinical signs and transcranial magnetic motor evoked potentials in dogs with intervertebral disc herniation. Veterinary Journal (London, England : 1997), 221, 48-53. https://doi.org/10.1016/j.tvjl.2017.01.015
Amendt HL, et al. Correlation Between Severity of Clinical Signs and Transcranial Magnetic Motor Evoked Potentials in Dogs With Intervertebral Disc Herniation. Vet J. 2017;221:48-53. PubMed PMID: 28283080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between severity of clinical signs and transcranial magnetic motor evoked potentials in dogs with intervertebral disc herniation. AU - Amendt,H-L, AU - Siedenburg,J S, AU - Steffensen,N, AU - Kordass,U, AU - Rohn,K, AU - Tipold,A, AU - Stein,V M, Y1 - 2017/02/01/ PY - 2015/12/09/received PY - 2017/01/20/revised PY - 2017/01/25/accepted PY - 2017/3/12/entrez PY - 2017/3/12/pubmed PY - 2017/6/27/medline KW - Intervertebral disc herniation KW - Spinal cord injury KW - Transcranial magnetic motor evoked potentials KW - Transcranial magnetic stimulation SP - 48 EP - 53 JF - Veterinary journal (London, England : 1997) JO - Vet. J. VL - 221 N2 - Transcranial magnetic motor evoked potentials (TMMEPs) can assess the functional integrity of the spinal cord descending motor pathways. In intervertebral disc herniation (IVDH), these pathways are compromised to varying degrees reflected by the severity of neurological deficits. The hypotheses of this study were as follows: (1) TMMEPs differ in dogs with IVDH and healthy control dogs; (2) TMMEPs reflect different severities of neurological signs; and (3) TMMEPs can document functional motor improvement and therefore monitor recovery of function. TMMEPs were recorded in 50 dogs with thoracolumbar IVDH. Clinical signs ranged from spinal hyperesthesia to non-ambulatory paraparesis in 19 dogs and paraplegia with/without deep pain sensation in 31 dogs. In these 31 paraplegic dogs, transcranial magnetic stimulation (TMS) was repeated during follow-up examinations. Ten healthy Beagle dogs served as controls. There was a significant increase in onset latency and decrease in peak-to-peak amplitude in the pelvic limb TMMEPs of dogs with spinal hyperesthesia to severe paraparesis compared to control dogs. Waveforms in dogs with IVDH were predominantly polyphasic in contrast to the biphasic waveforms of the control dogs. TMMEPs could not be generated in the pelvic limbs of paraplegic dogs. However, TMMEPs with markedly increased onset latencies and decreased peak-to-peak amplitudes reappeared in the pelvic limbs of dogs that were paraplegic before surgery and showed functional motor improvement during follow-up. The severity of neurological deficits was reflected by TMMEP findings, which could be used to document functional motor recovery in IVDH. TMS could therefore be used as an ancillary test to monitor response to therapy in dogs during rehabilitation. SN - 1532-2971 UR - https://www.unboundmedicine.com/medline/citation/28283080/Correlation_between_severity_of_clinical_signs_and_transcranial_magnetic_motor_evoked_potentials_in_dogs_with_intervertebral_disc_herniation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-0233(17)30029-1 DB - PRIME DP - Unbound Medicine ER -