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Endocrine disruption, oxidative stress, and testicular damage induced by 4-nonylphenol in Clarias gariepinus: the protective role of Cydonia oblonga.
Fish Physiol Biochem. 2017 Aug; 43(4):1095-1104.FP

Abstract

Exposure to xenoestrogens like 4-nonylphenol (NP) is recognized by disrupting endocrine functions and causes reproductive dysfunction in male fish. The present study aimed at investigating the 4-nonylphenol propensity to induce oxidative stress and hormonal disturbances in male catfish and at studying the protective role of quince (Cydonia oblonga). To fulfill this aim, catfish Clarias gariepinus were exposed to pure 100 μg/L 4-NP and to quince the leaf extract added to 4-NP, both for 15 days. The 4-NP exposure induced a marked increase in 17β-estradiol (E2), LH, and cortisol, while thyroid hormone (TSH, T3), testosterone (T), and FSH levels noticeably decreased; however, 4-NP had no effect on T4 level. Moreover, 4-NP exposure was accompanied by histological impairments in testes. Existence of 4-NP was associated with oxidative damage as evidenced by the significant increase (p < 0.05) of the enzymes, superoxidase dismutase (SOD), catalase (CAT), acetylcholinesterase (AchE), glutathione s-transferase, total antioxidant capacity (TAC), and malondialdehyde (MDA). Adding quince was effective to neutralize hormonal levels and to repair the testicular histological alterations. In response to quince remedy, the enzymes AchE and MDA reduced significantly (p < 0.05), while limited or no response was detected for other tested enzymes. Our results concluded that quince can antagonize 4-NP toxicity in catfish, confirming that quince leaf extract displayed antioxidant activities against the toxicity of hazardous chemicals.

Authors+Show Affiliations

Laboratory of Fish Biology and Pollution, Zoology Department, Faculty of Science, Assiut University, Assiut, 71516, Egypt. alaa_h254@yahoo.com.Laboratory of Fish Reproduction, Aquaculture Division, National Institute of Oceanography Fisheries, Alexandria, 21556, Egypt.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

28285354

Citation

Sayed, Alaa El-Din H., and Rania F K. Ismail. "Endocrine Disruption, Oxidative Stress, and Testicular Damage Induced By 4-nonylphenol in Clarias Gariepinus: the Protective Role of Cydonia Oblonga." Fish Physiology and Biochemistry, vol. 43, no. 4, 2017, pp. 1095-1104.
Sayed AEH, Ismail RFK. Endocrine disruption, oxidative stress, and testicular damage induced by 4-nonylphenol in Clarias gariepinus: the protective role of Cydonia oblonga. Fish Physiol Biochem. 2017;43(4):1095-1104.
Sayed, A. E. H., & Ismail, R. F. K. (2017). Endocrine disruption, oxidative stress, and testicular damage induced by 4-nonylphenol in Clarias gariepinus: the protective role of Cydonia oblonga. Fish Physiology and Biochemistry, 43(4), 1095-1104. https://doi.org/10.1007/s10695-017-0355-2
Sayed AEH, Ismail RFK. Endocrine Disruption, Oxidative Stress, and Testicular Damage Induced By 4-nonylphenol in Clarias Gariepinus: the Protective Role of Cydonia Oblonga. Fish Physiol Biochem. 2017;43(4):1095-1104. PubMed PMID: 28285354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocrine disruption, oxidative stress, and testicular damage induced by 4-nonylphenol in Clarias gariepinus: the protective role of Cydonia oblonga. AU - Sayed,Alaa El-Din H, AU - Ismail,Rania F K, Y1 - 2017/03/11/ PY - 2016/11/22/received PY - 2017/02/23/accepted PY - 2017/3/13/pubmed PY - 2018/1/13/medline PY - 2017/3/13/entrez KW - 4-Nonylphenol KW - Catfish KW - E2 KW - FSH KW - Oxidative KW - Quince SP - 1095 EP - 1104 JF - Fish physiology and biochemistry JO - Fish Physiol Biochem VL - 43 IS - 4 N2 - Exposure to xenoestrogens like 4-nonylphenol (NP) is recognized by disrupting endocrine functions and causes reproductive dysfunction in male fish. The present study aimed at investigating the 4-nonylphenol propensity to induce oxidative stress and hormonal disturbances in male catfish and at studying the protective role of quince (Cydonia oblonga). To fulfill this aim, catfish Clarias gariepinus were exposed to pure 100 μg/L 4-NP and to quince the leaf extract added to 4-NP, both for 15 days. The 4-NP exposure induced a marked increase in 17β-estradiol (E2), LH, and cortisol, while thyroid hormone (TSH, T3), testosterone (T), and FSH levels noticeably decreased; however, 4-NP had no effect on T4 level. Moreover, 4-NP exposure was accompanied by histological impairments in testes. Existence of 4-NP was associated with oxidative damage as evidenced by the significant increase (p < 0.05) of the enzymes, superoxidase dismutase (SOD), catalase (CAT), acetylcholinesterase (AchE), glutathione s-transferase, total antioxidant capacity (TAC), and malondialdehyde (MDA). Adding quince was effective to neutralize hormonal levels and to repair the testicular histological alterations. In response to quince remedy, the enzymes AchE and MDA reduced significantly (p < 0.05), while limited or no response was detected for other tested enzymes. Our results concluded that quince can antagonize 4-NP toxicity in catfish, confirming that quince leaf extract displayed antioxidant activities against the toxicity of hazardous chemicals. SN - 1573-5168 UR - https://www.unboundmedicine.com/medline/citation/28285354/Endocrine_disruption_oxidative_stress_and_testicular_damage_induced_by_4_nonylphenol_in_Clarias_gariepinus:_the_protective_role_of_Cydonia_oblonga_ L2 - https://dx.doi.org/10.1007/s10695-017-0355-2 DB - PRIME DP - Unbound Medicine ER -