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The effect of increasing body mass index on cardio-metabolic risk and biomarkers of oxidative stress and inflammation in nascent metabolic syndrome.
J Diabetes Complications. 2017 May; 31(5):810-813.JD

Abstract

The effect of BMI defined obesity on cardio-metabolic features and biomarkers of oxidative stress and inflammation in patients with nascent metabolic Syndrome (MetS) is poorly defined. Hence the aim of this study was to examine the effect of increasing obesity on the cardio metabolic risk profile, pro-oxidant state and pro-inflammatory features in nascent MetS patients without Diabetes or CVD. MetS was diagnosed by ATPIII criteria using waist circumference (WC) as the measure of adiposity. Patients (n=58) were stratified into overweight, obese and extreme obesity groups using BMI cut offs of 25-29.9, 30-39.9kg/m2 and ≥40kg/m2 and cardio-metabolic features, circulating and cellular biomarkers of oxidative stress and inflammation were determined and correlated with BMI. None of the main cardio-metabolic features including blood pressure, blood glucose, HDL-cholesterol, triglycerides, HOMA-IR, free fatty acids were increased with increasing BMI. Also none of the biomarkers of oxidative stress (ox-LDL, nitrotyrosine and monocyte superoxide anion release) were increased with increasing BMI. However, significant increase in hsCRP, the soluble TNFR1 and sTNFR2 and leptin, were observed with increasing adiposity. Other inflammatory bio-mediators (IL-1β, IL-6, IL-8, MCP-1, Toll-like receptors 2-4), endotoxin, LBP, sCD14 and HMGB1, adiponectin, and chemerin did not show significant increases with increasing BMI. Leptin, hsCRP, sTNFR1, and sTNFR2 correlated significantly with BMI. In conclusion, capturing the cardio-metabolic cluster of MetS that predisposed to both increased risk of diabetes and CVD, using waist circumference, as one of the 5 diagnostic criteria is sufficient and BMI does not appear to afford any major incremental benefit on the cardio-metabolic risk factors, increased oxidative stress and the majority of both cellular and circulating biomarkers of inflammation.

Authors+Show Affiliations

California North-state University College of Medicine, Elk Grove, Sacramento, CA, USA.Division of Biostatistics, University of Texas Southwestern Medical Center, Dallas, TX, USA.California North-state University College of Medicine, Elk Grove, Sacramento, CA, USA. Electronic address: ishwarlal.jialal@cnsu.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28285929

Citation

Pahwa, Roma, et al. "The Effect of Increasing Body Mass Index On Cardio-metabolic Risk and Biomarkers of Oxidative Stress and Inflammation in Nascent Metabolic Syndrome." Journal of Diabetes and Its Complications, vol. 31, no. 5, 2017, pp. 810-813.
Pahwa R, Adams-Huet B, Jialal I. The effect of increasing body mass index on cardio-metabolic risk and biomarkers of oxidative stress and inflammation in nascent metabolic syndrome. J Diabetes Complicat. 2017;31(5):810-813.
Pahwa, R., Adams-Huet, B., & Jialal, I. (2017). The effect of increasing body mass index on cardio-metabolic risk and biomarkers of oxidative stress and inflammation in nascent metabolic syndrome. Journal of Diabetes and Its Complications, 31(5), 810-813. https://doi.org/10.1016/j.jdiacomp.2017.02.010
Pahwa R, Adams-Huet B, Jialal I. The Effect of Increasing Body Mass Index On Cardio-metabolic Risk and Biomarkers of Oxidative Stress and Inflammation in Nascent Metabolic Syndrome. J Diabetes Complicat. 2017;31(5):810-813. PubMed PMID: 28285929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of increasing body mass index on cardio-metabolic risk and biomarkers of oxidative stress and inflammation in nascent metabolic syndrome. AU - Pahwa,Roma, AU - Adams-Huet,Beverley, AU - Jialal,Ishwarlal, Y1 - 2017/02/27/ PY - 2017/01/03/received PY - 2017/01/31/revised PY - 2017/02/16/accepted PY - 2017/3/14/pubmed PY - 2018/3/10/medline PY - 2017/3/14/entrez KW - Body mass index KW - Inflammation KW - Metabolic Syndrome KW - Obesity KW - Waist circumference SP - 810 EP - 813 JF - Journal of diabetes and its complications JO - J. Diabetes Complicat. VL - 31 IS - 5 N2 - The effect of BMI defined obesity on cardio-metabolic features and biomarkers of oxidative stress and inflammation in patients with nascent metabolic Syndrome (MetS) is poorly defined. Hence the aim of this study was to examine the effect of increasing obesity on the cardio metabolic risk profile, pro-oxidant state and pro-inflammatory features in nascent MetS patients without Diabetes or CVD. MetS was diagnosed by ATPIII criteria using waist circumference (WC) as the measure of adiposity. Patients (n=58) were stratified into overweight, obese and extreme obesity groups using BMI cut offs of 25-29.9, 30-39.9kg/m2 and ≥40kg/m2 and cardio-metabolic features, circulating and cellular biomarkers of oxidative stress and inflammation were determined and correlated with BMI. None of the main cardio-metabolic features including blood pressure, blood glucose, HDL-cholesterol, triglycerides, HOMA-IR, free fatty acids were increased with increasing BMI. Also none of the biomarkers of oxidative stress (ox-LDL, nitrotyrosine and monocyte superoxide anion release) were increased with increasing BMI. However, significant increase in hsCRP, the soluble TNFR1 and sTNFR2 and leptin, were observed with increasing adiposity. Other inflammatory bio-mediators (IL-1β, IL-6, IL-8, MCP-1, Toll-like receptors 2-4), endotoxin, LBP, sCD14 and HMGB1, adiponectin, and chemerin did not show significant increases with increasing BMI. Leptin, hsCRP, sTNFR1, and sTNFR2 correlated significantly with BMI. In conclusion, capturing the cardio-metabolic cluster of MetS that predisposed to both increased risk of diabetes and CVD, using waist circumference, as one of the 5 diagnostic criteria is sufficient and BMI does not appear to afford any major incremental benefit on the cardio-metabolic risk factors, increased oxidative stress and the majority of both cellular and circulating biomarkers of inflammation. SN - 1873-460X UR - https://www.unboundmedicine.com/medline/citation/28285929/The_effect_of_increasing_body_mass_index_on_cardio_metabolic_risk_and_biomarkers_of_oxidative_stress_and_inflammation_in_nascent_metabolic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(17)30011-9 DB - PRIME DP - Unbound Medicine ER -