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Antiviral activity of cationic amphiphilic drugs.

Abstract

INTRODUCTION

Emerging and reemerging viral infections represent a major concern for human and veterinary public health and there is an urgent need for the development of broad-spectrum antivirals. Areas covered: A recent strategy in antiviral research is based on the identification of molecules targeting host functions required for infection of multiple viruses. A number of FDA-approved drugs used to treat several human diseases are cationic amphiphilic drugs (CADs) that have the ability to accumulate inside cells affecting several structures/functions hijacked by viruses during infection. In this review we summarized the CADs' chemical properties and effects on the cells and reported the main FDA-approved CADs that have been identified so far as potential antivirals in drug repurposing studies. Expert commentary: Although there have been concerns regarding the efficacy and the possible side effects of the off-label use of CADs as antivirals, they seem to represent a promising starting point for the development of broad-spectrum antiviral strategies. Further knowledge about their mechanism of action is required to improve their antiviral activity and to reduce the risk of side effects.

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  • Authors+Show Affiliations

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    a Department of Molecular Medicine , University of Padova , Padova , Italy.

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    a Department of Molecular Medicine , University of Padova , Padova , Italy.

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    a Department of Molecular Medicine , University of Padova , Padova , Italy.

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    b Clinica Medica 1, Department of Medicine , University of Padova , Padova , Italy.

    a Department of Molecular Medicine , University of Padova , Padova , Italy.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28286997