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Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population.
Lipids Health Dis. 2017 Mar 14; 16(1):54.LH

Abstract

BACKGROUND

Previous studies established a possible link among hyperhomocysteinemia (HHcy), dyslipidemia, and atherosclerosis. However, there was limited epidemic data concerning the relation between HHcy and lipid profiles, especially in community-based Chinese populations. This study aim to investigate the association of plasma homocysteine (Hcy) level with lipid profiles in a Chinese community-based population without lipid-lowering treatment.

METHOD

A total of 4660 Chinese subjects from a cohort of the Shijingshan district in Beijing were included in the analysis. Plasma total Hcy, serum lipid files including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) as well as relevant metabolic risk factors were measured. Multivariate regression models adjusting for age, gender, smoking, drinking, physical activity, vitamin B supplement, body mass index, fasting blood glucose level, serum creatinine, systolic and diastolic blood pressure were used to evaluate associations of Hcy and lipid profiles.

RESULT

Subjects were 56.75 ± 8.91 years old, and 38.15% were male. Median (IQR) Hcy was 11.98 (10.00-14.93) μmol/L, and 24.4% had HHcy (defined as Hcy ≥ 15 μmol/L). Mean (SD) baseline TC was 5.34 ± 0.98 mmol/L, LDL-C was 3.27 ± 0.81 mmol/L, and HDL-C was 1.43 ± 0.38 mmol/L. Median (IQR) of TG was 1.28 (0.91-1.85) mmol/L. In multivariable linear-regression analyses, lnHcy (ln transformation for Hcy) level was positively associated with lnTG (adjusted β = 0.075, SE = 0.021, P = 0.001). Using Hcy < 15 μmol/L as a reference, HHcy was independently associated with both lnTG (adjusted β = 0.056, SE = 0.020, P = 0.004) and lnHDL (adjusted β = -0.018, SE = 0.009, P = 0.038). In multivariable logistic-regression analyses, HHcy was associated with increasing risk of low HDL-C (HDL-C < 1.04 mmol/L; adjusted odds ratio [OR] =1.406, 95% confidence interval [CI]: 1.143 - 1.728, P = 0.001) and hypertriglyceridemia (TG ≥ 1.7 mmol/L; adjusted OR = 1.293, 95% CI: 1.096-1.524, P = 0.002) after adjusting the confounders. However, there were no significant associations between Hcy and TC or LDL-C.

CONCLUSION

The present study showed that HHcy was independently associated with hypertriglyceridemia and low levels of HDL-C, which provides evidence that Hcy levels might affect HDL-C and TG metabolism.

Authors+Show Affiliations

Department of Cardiology, Peking University First Hospital, Beijing, China.Department of Cardiology, Peking University First Hospital, Beijing, China.Department of Cardiology, Peking University First Hospital, Beijing, China.Department of Cardiology, Peking University First Hospital, Beijing, China.Department of Endocrinology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.Department of Epidemic & Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.Department of Cardiology, Peking University First Hospital, Beijing, China.Department of Cardiology, Peking University First Hospital, Beijing, China. drzhy1108@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28288621

Citation

Momin, Mohetaboer, et al. "Relationship Between Plasma Homocysteine Level and Lipid Profiles in a Community-based Chinese Population." Lipids in Health and Disease, vol. 16, no. 1, 2017, p. 54.
Momin M, Jia J, Fan F, et al. Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population. Lipids Health Dis. 2017;16(1):54.
Momin, M., Jia, J., Fan, F., Li, J., Dou, J., Chen, D., Huo, Y., & Zhang, Y. (2017). Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population. Lipids in Health and Disease, 16(1), 54. https://doi.org/10.1186/s12944-017-0441-6
Momin M, et al. Relationship Between Plasma Homocysteine Level and Lipid Profiles in a Community-based Chinese Population. Lipids Health Dis. 2017 Mar 14;16(1):54. PubMed PMID: 28288621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population. AU - Momin,Mohetaboer, AU - Jia,Jia, AU - Fan,Fangfang, AU - Li,Jianping, AU - Dou,Jingtao, AU - Chen,Dafang, AU - Huo,Yong, AU - Zhang,Yan, Y1 - 2017/03/14/ PY - 2016/08/10/received PY - 2017/03/02/accepted PY - 2017/3/15/entrez PY - 2017/3/16/pubmed PY - 2017/5/16/medline KW - High-density lipoprotein cholesterol KW - Homocysteine KW - Triglycerides SP - 54 EP - 54 JF - Lipids in health and disease JO - Lipids Health Dis VL - 16 IS - 1 N2 - BACKGROUND: Previous studies established a possible link among hyperhomocysteinemia (HHcy), dyslipidemia, and atherosclerosis. However, there was limited epidemic data concerning the relation between HHcy and lipid profiles, especially in community-based Chinese populations. This study aim to investigate the association of plasma homocysteine (Hcy) level with lipid profiles in a Chinese community-based population without lipid-lowering treatment. METHOD: A total of 4660 Chinese subjects from a cohort of the Shijingshan district in Beijing were included in the analysis. Plasma total Hcy, serum lipid files including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) as well as relevant metabolic risk factors were measured. Multivariate regression models adjusting for age, gender, smoking, drinking, physical activity, vitamin B supplement, body mass index, fasting blood glucose level, serum creatinine, systolic and diastolic blood pressure were used to evaluate associations of Hcy and lipid profiles. RESULT: Subjects were 56.75 ± 8.91 years old, and 38.15% were male. Median (IQR) Hcy was 11.98 (10.00-14.93) μmol/L, and 24.4% had HHcy (defined as Hcy ≥ 15 μmol/L). Mean (SD) baseline TC was 5.34 ± 0.98 mmol/L, LDL-C was 3.27 ± 0.81 mmol/L, and HDL-C was 1.43 ± 0.38 mmol/L. Median (IQR) of TG was 1.28 (0.91-1.85) mmol/L. In multivariable linear-regression analyses, lnHcy (ln transformation for Hcy) level was positively associated with lnTG (adjusted β = 0.075, SE = 0.021, P = 0.001). Using Hcy < 15 μmol/L as a reference, HHcy was independently associated with both lnTG (adjusted β = 0.056, SE = 0.020, P = 0.004) and lnHDL (adjusted β = -0.018, SE = 0.009, P = 0.038). In multivariable logistic-regression analyses, HHcy was associated with increasing risk of low HDL-C (HDL-C < 1.04 mmol/L; adjusted odds ratio [OR] =1.406, 95% confidence interval [CI]: 1.143 - 1.728, P = 0.001) and hypertriglyceridemia (TG ≥ 1.7 mmol/L; adjusted OR = 1.293, 95% CI: 1.096-1.524, P = 0.002) after adjusting the confounders. However, there were no significant associations between Hcy and TC or LDL-C. CONCLUSION: The present study showed that HHcy was independently associated with hypertriglyceridemia and low levels of HDL-C, which provides evidence that Hcy levels might affect HDL-C and TG metabolism. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/28288621/Relationship_between_plasma_homocysteine_level_and_lipid_profiles_in_a_community_based_Chinese_population_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-017-0441-6 DB - PRIME DP - Unbound Medicine ER -