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Evidence for delta receptor mediation of [D-Pen2,D-Pen5]-enkephalin (DPDPE) analgesia in mice.
NIDA Res Monogr. 1986; 75:442-5.NR

Abstract

Possible involvement of cerebral delta opioid receptors in antinociceptive processes was studied in a test utilizing heat as the noxious thermal stimulus. The investigation focused on selective agonists and antagonists for mu and delta opioid receptors. Morphine and [D-Ala2,NMPhe4, Gly-ol]enkephalin (DAGO) were used as agonists for the mu receptor while [D-Pen2,D-Pen5]enkephalin (DPDPE) was the agonist for the delta receptor. Two approaches were employed: first, the intracerebroventricular (i.c.v.) analgesic activity of the agonists was determined in the absence, and in the presence of graded i.c.v. doses of the selective delta antagonist, ICI 174,864 (N,N diallyl-Tyr-Aib-Aib-Phe-Leu-OH) (where Aib is alpha-aminoisobutyric acid); second, acute tolerance to morphine was produced and the possible presence of acute cross-tolerance between subcutaneous (s.c.) morphine and the delta agonist investigated. ICI 174,864 antagonized the analgesia produced by DPDPE, but not that resulting from morphine or DAGO. Morphine pretreatment resulted in the development of acute tolerance to i.c.v. morphine, and acute cross-tolerance to i.c.v. DAGO, but not to i.c.v. DPDPE. These results provide evidence that both cerebral delta and mu opioid receptors are responsible for the mediation of analgesia in tests utilizing heat as the nociceptive stimulus.

Authors+Show Affiliations

Department of Pharmacology, University of Arizona Health Sciences Center, Tucson 85724.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2828989

Citation

Heyman, J S., et al. "Evidence for Delta Receptor Mediation of [D-Pen2,D-Pen5]-enkephalin (DPDPE) Analgesia in Mice." NIDA Research Monograph, vol. 75, 1986, pp. 442-5.
Heyman JS, Mosberg HI, Porreca F. Evidence for delta receptor mediation of [D-Pen2,D-Pen5]-enkephalin (DPDPE) analgesia in mice. NIDA Res Monogr. 1986;75:442-5.
Heyman, J. S., Mosberg, H. I., & Porreca, F. (1986). Evidence for delta receptor mediation of [D-Pen2,D-Pen5]-enkephalin (DPDPE) analgesia in mice. NIDA Research Monograph, 75, 442-5.
Heyman JS, Mosberg HI, Porreca F. Evidence for Delta Receptor Mediation of [D-Pen2,D-Pen5]-enkephalin (DPDPE) Analgesia in Mice. NIDA Res Monogr. 1986;75:442-5. PubMed PMID: 2828989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for delta receptor mediation of [D-Pen2,D-Pen5]-enkephalin (DPDPE) analgesia in mice. AU - Heyman,J S, AU - Mosberg,H I, AU - Porreca,F, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 442 EP - 5 JF - NIDA research monograph JO - NIDA Res Monogr VL - 75 N2 - Possible involvement of cerebral delta opioid receptors in antinociceptive processes was studied in a test utilizing heat as the noxious thermal stimulus. The investigation focused on selective agonists and antagonists for mu and delta opioid receptors. Morphine and [D-Ala2,NMPhe4, Gly-ol]enkephalin (DAGO) were used as agonists for the mu receptor while [D-Pen2,D-Pen5]enkephalin (DPDPE) was the agonist for the delta receptor. Two approaches were employed: first, the intracerebroventricular (i.c.v.) analgesic activity of the agonists was determined in the absence, and in the presence of graded i.c.v. doses of the selective delta antagonist, ICI 174,864 (N,N diallyl-Tyr-Aib-Aib-Phe-Leu-OH) (where Aib is alpha-aminoisobutyric acid); second, acute tolerance to morphine was produced and the possible presence of acute cross-tolerance between subcutaneous (s.c.) morphine and the delta agonist investigated. ICI 174,864 antagonized the analgesia produced by DPDPE, but not that resulting from morphine or DAGO. Morphine pretreatment resulted in the development of acute tolerance to i.c.v. morphine, and acute cross-tolerance to i.c.v. DAGO, but not to i.c.v. DPDPE. These results provide evidence that both cerebral delta and mu opioid receptors are responsible for the mediation of analgesia in tests utilizing heat as the nociceptive stimulus. SN - 1046-9516 UR - https://www.unboundmedicine.com/medline/citation/2828989/Evidence_for_delta_receptor_mediation_of_[D_Pen2D_Pen5]_enkephalin__DPDPE__analgesia_in_mice_ L2 - https://antibodies.cancer.gov/detail/CPTC-GST+Mu1-6 DB - PRIME DP - Unbound Medicine ER -