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Influence of hydrophilic polymers on celecoxib complexation with hydroxypropyl β-cyclodextrin.
AAPS PharmSciTech. 2006 Sep; 7(3):E184-E189.AP

Abstract

Complexation of celecoxib with hydroxypropyl β-cyclodextrin (HPβCD) in the presence and absence of 3 hydrophilic polymers-polyvinyl pyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), and polyethylene glycol (PEG)-was investigated with an objective of evaluating the effect of hydrophilic polymers on the complexation and solubilizing efficiencies of HPβCD and on the dissolution rate of celecoxib from the HPβCD complexes. The phase solubility studies indicated the formation of celecoxib-HPβCD inclusion complexes at a 1∶1M ratio in solution in both the presence and the absence of hydrophilic polymers. The complexes formed were quite stable. Addition of hydrophilic polymers markedly enhanced the complexation and solubilizing efficiencies of HPβCD. Solid inclusion complexes of celecoxib-HPβCD were prepared in 1∶1 and 1∶2 ratios by the kneading method, with and without the addition of hydrophilic polymers. The solubility and dissolution rate of celecoxib were significantly improved by complexation with HPβCD. The celecoxib-HPβCD (1∶2) inclusion complex yielded a 36.57-fold increase in the dissolution rate of celecoxib. The addition of hydrophilic polymers also markedly enhanced the dissolution rate of celecoxib from HPβCD complexes: a 72.60-, 61.25-, and 39.15-fold increase was observed with PVP, HPMC, and PEG, respectively. Differential scanning calorimetry and X-ray diffractometry indicated stronger drug amorphization and entrapment in HPβCD because of the combined action of HPβCD and the hydrophilic polymers.

Authors+Show Affiliations

University College of Pharmaceutical Sciences, Andhra University, 530 003, Visakhapatnam, AP, India. profkprc@rediffmail.com.University College of Pharmaceutical Sciences, Andhra University, 530 003, Visakhapatnam, AP, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28290014

Citation

Chowdary, Kora Pattabhi Ramaiah, and Sekuboyina Vijaya Srinivas. "Influence of Hydrophilic Polymers On Celecoxib Complexation With Hydroxypropyl Β-cyclodextrin." AAPS PharmSciTech, vol. 7, no. 3, 2006, pp. E184-E189.
Chowdary KP, Srinivas SV. Influence of hydrophilic polymers on celecoxib complexation with hydroxypropyl β-cyclodextrin. AAPS PharmSciTech. 2006;7(3):E184-E189.
Chowdary, K. P., & Srinivas, S. V. (2006). Influence of hydrophilic polymers on celecoxib complexation with hydroxypropyl β-cyclodextrin. AAPS PharmSciTech, 7(3), E184-E189. https://doi.org/10.1208/pt070379
Chowdary KP, Srinivas SV. Influence of Hydrophilic Polymers On Celecoxib Complexation With Hydroxypropyl Β-cyclodextrin. AAPS PharmSciTech. 2006;7(3):E184-E189. PubMed PMID: 28290014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of hydrophilic polymers on celecoxib complexation with hydroxypropyl β-cyclodextrin. AU - Chowdary,Kora Pattabhi Ramaiah, AU - Srinivas,Sekuboyina Vijaya, Y1 - 2017/03/08/ PY - 2006/01/24/received PY - 2006/06/07/accepted PY - 2017/3/15/entrez PY - 2006/9/1/pubmed PY - 2006/9/1/medline KW - Celecoxib KW - complexation KW - dissolution rate KW - hydrophilic polymers KW - hydroxypropyl β-cyclodextrin SP - E184 EP - E189 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 7 IS - 3 N2 - Complexation of celecoxib with hydroxypropyl β-cyclodextrin (HPβCD) in the presence and absence of 3 hydrophilic polymers-polyvinyl pyrrolidone (PVP), hydroxypropyl methylcellulose (HPMC), and polyethylene glycol (PEG)-was investigated with an objective of evaluating the effect of hydrophilic polymers on the complexation and solubilizing efficiencies of HPβCD and on the dissolution rate of celecoxib from the HPβCD complexes. The phase solubility studies indicated the formation of celecoxib-HPβCD inclusion complexes at a 1∶1M ratio in solution in both the presence and the absence of hydrophilic polymers. The complexes formed were quite stable. Addition of hydrophilic polymers markedly enhanced the complexation and solubilizing efficiencies of HPβCD. Solid inclusion complexes of celecoxib-HPβCD were prepared in 1∶1 and 1∶2 ratios by the kneading method, with and without the addition of hydrophilic polymers. The solubility and dissolution rate of celecoxib were significantly improved by complexation with HPβCD. The celecoxib-HPβCD (1∶2) inclusion complex yielded a 36.57-fold increase in the dissolution rate of celecoxib. The addition of hydrophilic polymers also markedly enhanced the dissolution rate of celecoxib from HPβCD complexes: a 72.60-, 61.25-, and 39.15-fold increase was observed with PVP, HPMC, and PEG, respectively. Differential scanning calorimetry and X-ray diffractometry indicated stronger drug amorphization and entrapment in HPβCD because of the combined action of HPβCD and the hydrophilic polymers. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/28290014/Influence_of_hydrophilic_polymers_on_celecoxib_complexation_with_hydroxypropyl_β_cyclodextrin_ DB - PRIME DP - Unbound Medicine ER -
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