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Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride.
AAPS PharmSciTech. 2006 Mar; 7(1):E168-E174.AP

Abstract

The objective of this work was to develop matrix sustained-release tablets of highly water-soluble tramadol HCl using natural gums (xanthan [X gum] and guar [G gum]) as cost-effective, nontoxic, easily available, and suitable hydrophilic matrix systems compared with the extensively investigated hydrophilic matrices (ie, hydroxypropyl methylcellulose [HPMC]/carboxymethyl cellulose [CMC] with respect to in vitro drug release rate) and hydration rate of the polymers. Matrix tablets of tramadol (dose 100 mg) were produced by direct compression method. Different ratios, of 100∶0, 80∶20, 60∶40, 20∶80, 0∶100 of G gum (or X):HPMC, X gum:G gum, and triple mixture of these polymers (G gum, X gum, HPMC) were applied. After evaluation of physical characteristics of tablets, the dissolution test was, performed in the phosphate buffer media (pH 7.4) up to 8 hours. Tablets with only X had the highest mean dissolution time (MDT), the least dissolution efficiency (DE8%), and released the drug following a zero-order model via swelling, diffusion, and erosion mechanisms. Guar gum alone could not efficiently control the drug release, while X and all combinations of natural gums with HPMC could retard tramadol HCl release. However, according to the similarity factor (f 2), pure HPMC and H8G2 were the most similar formulations to Topalgic-LP as the reference standard.

Authors+Show Affiliations

Department of Pharmaceutics, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran. varshosaz@pharm.mui.ac.ir.Department of Pharmaceutics, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Pharmaceutics, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28290039

Citation

Varshosaz, Jaleh, et al. "Use of Hydrophilic Natural Gums in Formulation of Sustained-release Matrix Tablets of Tramadol Hydrochloride." AAPS PharmSciTech, vol. 7, no. 1, 2006, pp. E168-E174.
Varshosaz J, Tavakoli N, Kheirolahi F. Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride. AAPS PharmSciTech. 2006;7(1):E168-E174.
Varshosaz, J., Tavakoli, N., & Kheirolahi, F. (2006). Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride. AAPS PharmSciTech, 7(1), E168-E174. https://doi.org/10.1208/pt070124
Varshosaz J, Tavakoli N, Kheirolahi F. Use of Hydrophilic Natural Gums in Formulation of Sustained-release Matrix Tablets of Tramadol Hydrochloride. AAPS PharmSciTech. 2006;7(1):E168-E174. PubMed PMID: 28290039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride. AU - Varshosaz,Jaleh, AU - Tavakoli,Naser, AU - Kheirolahi,Fatemeh, Y1 - 2017/03/08/ PY - 2005/08/24/received PY - 2005/10/31/accepted PY - 2017/3/15/entrez PY - 2006/3/1/pubmed PY - 2006/3/1/medline KW - guar gum KW - natural gums KW - sustained-release KW - tramadol KW - xanthan SP - E168 EP - E174 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 7 IS - 1 N2 - The objective of this work was to develop matrix sustained-release tablets of highly water-soluble tramadol HCl using natural gums (xanthan [X gum] and guar [G gum]) as cost-effective, nontoxic, easily available, and suitable hydrophilic matrix systems compared with the extensively investigated hydrophilic matrices (ie, hydroxypropyl methylcellulose [HPMC]/carboxymethyl cellulose [CMC] with respect to in vitro drug release rate) and hydration rate of the polymers. Matrix tablets of tramadol (dose 100 mg) were produced by direct compression method. Different ratios, of 100∶0, 80∶20, 60∶40, 20∶80, 0∶100 of G gum (or X):HPMC, X gum:G gum, and triple mixture of these polymers (G gum, X gum, HPMC) were applied. After evaluation of physical characteristics of tablets, the dissolution test was, performed in the phosphate buffer media (pH 7.4) up to 8 hours. Tablets with only X had the highest mean dissolution time (MDT), the least dissolution efficiency (DE8%), and released the drug following a zero-order model via swelling, diffusion, and erosion mechanisms. Guar gum alone could not efficiently control the drug release, while X and all combinations of natural gums with HPMC could retard tramadol HCl release. However, according to the similarity factor (f 2), pure HPMC and H8G2 were the most similar formulations to Topalgic-LP as the reference standard. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/28290039/Use_of_hydrophilic_natural_gums_in_formulation_of_sustained_release_matrix_tablets_of_tramadol_hydrochloride_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28290039/ DB - PRIME DP - Unbound Medicine ER -
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