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Plasma brain-derived neurotrophic factor in women with pelvic pain: a potential biomarker for endometriosis?
Biomark Med. 2017 Apr; 11(4):313-317.BM

Abstract

AIM

To test whether plasma BDNF levels are useful to predict the presence of endometriosis in women with pelvic pain.

PATIENTS & METHODS

Prospective cross-sectional study including 67 consecutive women aged 24-49 years, scheduled for laparoscopy due to chronic pelvic pain. Preoperative plasma samples were assayed for BDNF using a commercial enzyme immunoassay.

RESULTS

Women with ovarian endometrioma had higher preoperative plasma BDNF (1063 ± 157 pg/ml) compared with women with other benign ovarian tumors (537 ± 131 pg/ml, F = 2.53; p = 0.02). However, plasma BDNF levels were not helpful to indicate the presence of peritoneal or deep infiltrating endometriosis. Plasma BDNF levels were positively correlated with the severity of pelvic pain (r = 0.489; p < 0.0001).

CONCLUSION

Plasma BDNF might be a biomarker of ovarian endometrioma but not a useful diagnostic marker to detect other forms of endometriosis in women with painful symptoms.

Authors+Show Affiliations

Department of Obstetrics & Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.Department of Obstetrics & Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.Department of Obstetrics & Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Department of Psychiatry & Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.Department of Obstetrics & Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28290209

Citation

Rocha, Ana L., et al. "Plasma Brain-derived Neurotrophic Factor in Women With Pelvic Pain: a Potential Biomarker for Endometriosis?" Biomarkers in Medicine, vol. 11, no. 4, 2017, pp. 313-317.
Rocha AL, Vieira EL, Ferreira MC, et al. Plasma brain-derived neurotrophic factor in women with pelvic pain: a potential biomarker for endometriosis? Biomark Med. 2017;11(4):313-317.
Rocha, A. L., Vieira, E. L., Ferreira, M. C., Maia, L. M., Teixeira, A. L., & Reis, F. M. (2017). Plasma brain-derived neurotrophic factor in women with pelvic pain: a potential biomarker for endometriosis? Biomarkers in Medicine, 11(4), 313-317. https://doi.org/10.2217/bmm-2016-0327
Rocha AL, et al. Plasma Brain-derived Neurotrophic Factor in Women With Pelvic Pain: a Potential Biomarker for Endometriosis. Biomark Med. 2017;11(4):313-317. PubMed PMID: 28290209.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma brain-derived neurotrophic factor in women with pelvic pain: a potential biomarker for endometriosis? AU - Rocha,Ana L, AU - Vieira,Erica L, AU - Ferreira,Márcia C, AU - Maia,Laura M, AU - Teixeira,Antonio L, AU - Reis,Fernando M, Y1 - 2017/03/14/ PY - 2017/3/16/pubmed PY - 2017/10/27/medline PY - 2017/3/15/entrez KW - BDNF KW - benign ovarian tumor KW - biomarker KW - endometrioma KW - endometriosis KW - inflammation KW - laparoscopy KW - nerve fiber KW - pelvic pain SP - 313 EP - 317 JF - Biomarkers in medicine JO - Biomark Med VL - 11 IS - 4 N2 - AIM: To test whether plasma BDNF levels are useful to predict the presence of endometriosis in women with pelvic pain. PATIENTS & METHODS: Prospective cross-sectional study including 67 consecutive women aged 24-49 years, scheduled for laparoscopy due to chronic pelvic pain. Preoperative plasma samples were assayed for BDNF using a commercial enzyme immunoassay. RESULTS: Women with ovarian endometrioma had higher preoperative plasma BDNF (1063 ± 157 pg/ml) compared with women with other benign ovarian tumors (537 ± 131 pg/ml, F = 2.53; p = 0.02). However, plasma BDNF levels were not helpful to indicate the presence of peritoneal or deep infiltrating endometriosis. Plasma BDNF levels were positively correlated with the severity of pelvic pain (r = 0.489; p < 0.0001). CONCLUSION: Plasma BDNF might be a biomarker of ovarian endometrioma but not a useful diagnostic marker to detect other forms of endometriosis in women with painful symptoms. SN - 1752-0371 UR - https://www.unboundmedicine.com/medline/citation/28290209/Plasma_brain_derived_neurotrophic_factor_in_women_with_pelvic_pain:_a_potential_biomarker_for_endometriosis L2 - http://www.futuremedicine.com/doi/full/10.2217/bmm-2016-0327?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -